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Aging related changes in circulating reactive oxygen species (ROS) and protein carbonyls are indicative of liver oxidative injury.

Luceri C, Bigagli E, Femia AP, Caderni G, Giovannelli L, Lodovici M.

Toxicol Rep. 2017 Dec 21;5:141-145. doi: 10.1016/j.toxrep.2017.12.017. eCollection 2018.


Pomegranate By-Products in Colorectal Cancer Chemoprevention: Effects in Apc-Mutated Pirc Rats and Mechanistic Studies In Vitro and Ex Vivo.

Tortora K, Femia AP, Romagnoli A, Sineo I, Khatib M, Mulinacci N, Giovannelli L, Caderni G.

Mol Nutr Food Res. 2018 Jan;62(2). doi: 10.1002/mnfr.201700401. Epub 2017 Nov 22.


Astragali radix: could it be an adjuvant for oxaliplatin-induced neuropathy?

Di Cesare Mannelli L, Pacini A, Micheli L, Femia AP, Maresca M, Zanardelli M, Vannacci A, Gallo E, Bilia AR, Caderni G, Firenzuoli F, Mugelli A, Ghelardini C.

Sci Rep. 2017 Feb 10;7:42021. doi: 10.1038/srep42021.


Risk factors for colorectal cancer in man induce aberrant crypt foci in rats: Preliminary findings.

Yang K, Fard S, Furrer R, Archer MC, Bruce WR, Lip H, Mehta R, O'Brien PJ, Giacca A, Ward WE, Femia AP, Caderni G, Medline A, Banks K.

Nutr Cancer. 2016;68(1):94-104. doi: 10.1080/01635581.2016.1115098. Epub 2015 Dec 28.


Sulindac, 3,3'-diindolylmethane and curcumin reduce carcinogenesis in the Pirc rat, an Apc-driven model of colon carcinogenesis.

Femia AP, Soares PV, Luceri C, Lodovici M, Giannini A, Caderni G.

BMC Cancer. 2015 Sep 3;15:611. doi: 10.1186/s12885-015-1627-9.


Apc-driven colon carcinogenesis in Pirc rat is strongly reduced by polyethylene glycol.

Femia AP, Becherucci C, Crucitta S, Caderni G.

Int J Cancer. 2015 Nov 1;137(9):2270-3. doi: 10.1002/ijc.29581. Epub 2015 May 5.


Multiple mucin depleted foci, high proliferation and low apoptotic response in the onset of colon carcinogenesis of the PIRC rat, mutated in Apc.

Femia AP, Luceri C, Soares PV, Lodovici M, Caderni G.

Int J Cancer. 2015 Mar 15;136(6):E488-95. doi: 10.1002/ijc.29232. Epub 2014 Oct 6.


Characterization of hERG1 channel role in mouse colorectal carcinogenesis.

Fiore A, Carraresi L, Morabito A, Polvani S, Fortunato A, Lastraioli E, Femia AP, De Lorenzo E, Caderni G, Arcangeli A.

Cancer Med. 2013 Oct;2(5):583-94. doi: 10.1002/cam4.72. Epub 2013 Jul 22.


Long-term treatment with Sitagliptin, a dipeptidyl peptidase-4 inhibitor, reduces colon carcinogenesis and reactive oxygen species in 1,2-dimethylhydrazine-induced rats.

Femia AP, Raimondi L, Maglieri G, Lodovici M, Mannucci E, Caderni G.

Int J Cancer. 2013 Nov 15;133(10):2498-503. doi: 10.1002/ijc.28260. Epub 2013 May 29.


Marie Ménard apples with high polyphenol content and a low-fat diet reduce 1,2-dimethylhydrazine-induced colon carcinogenesis in rats: effects on inflammation and apoptosis.

Femia AP, Luceri C, Bianchini F, Salvadori M, Salvianti F, Pinzani P, Dolara P, Calorini L, Caderni G.

Mol Nutr Food Res. 2012 Aug;56(8):1353-7. doi: 10.1002/mnfr.201200122. Epub 2012 Jun 20.


Mucin depleted foci, colonic preneoplastic lesions lacking Muc2, show up-regulation of Tlr2 but not bacterial infiltration.

Femia AP, Swidsinski A, Dolara P, Salvadori M, Amedei A, Caderni G.

PLoS One. 2012;7(1):e29918. doi: 10.1371/journal.pone.0029918. Epub 2012 Jan 5.


Sustained proliferation and resistance to apoptosis after a cytotoxic insult are early alterations in rat colon carcinogenesis.

Femia AP, Salvianti F, Luceri C, Dolara P, Salvadori M, Pinzani P, Caderni G.

Int J Cancer. 2012 Aug 1;131(3):529-36. doi: 10.1002/ijc.26406. Epub 2011 Oct 5.


Gene expression profile and genomic alterations in colonic tumours induced by 1,2-dimethylhydrazine (DMH) in rats.

Femia AP, Luceri C, Toti S, Giannini A, Dolara P, Caderni G.

BMC Cancer. 2010 May 11;10:194. doi: 10.1186/1471-2407-10-194.


Arabinoxylan-oligosaccharides (AXOS) reduce preneoplastic lesions in the colon of rats treated with 1,2-dimethylhydrazine (DMH).

Femia AP, Salvadori M, Broekaert WF, François IE, Delcour JA, Courtin CM, Caderni G.

Eur J Nutr. 2010 Mar;49(2):127-32. doi: 10.1007/s00394-009-0050-x. Epub 2009 Aug 27.


Reduction of colonic inflammation in HLA-B27 transgenic rats by feeding Marie Ménard apples, rich in polyphenols.

Castagnini C, Luceri C, Toti S, Bigagli E, Caderni G, Femia AP, Giovannelli L, Lodovici M, Pitozzi V, Salvadori M, Messerini L, Martin R, Zoetendal EG, Gaj S, Eijssen L, Evelo CT, Renard CM, Baron A, Dolara P.

Br J Nutr. 2009 Dec;102(11):1620-8. doi: 10.1017/S0007114509990936. Epub 2009 Jul 22.


Correspondence between flat aberrant crypt foci and mucin-depleted foci in rodent colon carcinogenesis.

Femia AP, Paulsen JE, Dolara P, Alexander J, Caderni G.

Anticancer Res. 2008 Nov-Dec;28(6A):3771-5.


Identification of mucin depleted foci in the human colon.

Femia AP, Giannini A, Fazi M, Tarquini E, Salvadori M, Roncucci L, Tonelli F, Dolara P, Caderni G.

Cancer Prev Res (Phila). 2008 Dec;1(7):562-7. doi: 10.1158/1940-6207.CAPR-08-0125.

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