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Items: 1 to 20 of 60

1.

An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes.

Futch HS, McFarland KN, Moore BD, Kuhn MZ, Giasson BI, Ladd TB, Scott KA, Shapiro MR, Nosacka RL, Goodwin MS, Ran Y, Cruz PE, Ryu DH, Croft CL, Levites Y, Janus C, Chakrabarty P, Judge AR, Brusko TM, de Kloet AD, Krause EG, Golde TE.

J Exp Med. 2019 Aug 29. pii: jem.20190430. doi: 10.1084/jem.20190430. [Epub ahead of print]

PMID:
31467037
2.

Islet-immune interactions in type 1 diabetes: the nexus of beta cell destruction.

Peters L, Posgai A, Brusko TM.

Clin Exp Immunol. 2019 Jul 15. doi: 10.1111/cei.13349. [Epub ahead of print] Review.

PMID:
31309537
3.

Standardizing T-Cell Biomarkers in Type 1 Diabetes: Challenges and Recent Advances.

Ahmed S, Cerosaletti K, James E, Long SA, Mannering S, Speake C, Nakayama M, Tree T, Roep BO, Herold KC, Brusko TM.

Diabetes. 2019 Jul;68(7):1366-1379. doi: 10.2337/db19-0119.

PMID:
31221801
4.

Metformin Inhibits the Type 1 IFN Response in Human CD4+ T Cells.

Titov AA, Baker HV, Brusko TM, Sobel ES, Morel L.

J Immunol. 2019 Jul 15;203(2):338-348. doi: 10.4049/jimmunol.1801651. Epub 2019 Jun 3.

PMID:
31160534
5.

Pleiotropic roles of the insulin-like growth factor axis in type 1 diabetes.

Shapiro MR, Atkinson MA, Brusko TM.

Curr Opin Endocrinol Diabetes Obes. 2019 Aug;26(4):188-194. doi: 10.1097/MED.0000000000000484.

PMID:
31145130
6.

Dual-Sized Microparticle System for Generating Suppressive Dendritic Cells Prevents and Reverses Type 1 Diabetes in the Nonobese Diabetic Mouse Model.

Lewis JS, Stewart JM, Marshall GP, Carstens MR, Zhang Y, Dolgova NV, Xia C, Brusko TM, Wasserfall CH, Clare-Salzler MJ, Atkinson MA, Keselowsky BG.

ACS Biomater Sci Eng. 2019 May 13;5(5):2631-2646. doi: 10.1021/acsbiomaterials.9b00332. Epub 2019 Mar 26.

7.

Crossreactive public TCR sequences undergo positive selection in the human thymic repertoire.

Khosravi-Maharlooei M, Obradovic A, Misra A, Motwani K, Holzl M, Seay HR, DeWolf S, Nauman G, Danzl N, Li H, Ho SH, Winchester R, Shen Y, Brusko TM, Sykes M.

J Clin Invest. 2019 Mar 28;129(6):2446-2462. doi: 10.1172/JCI124358.

8.

A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells.

Van Gool F, Nguyen MLT, Mumbach MR, Satpathy AT, Rosenthal WL, Giacometti S, Le DT, Liu W, Brusko TM, Anderson MS, Rudensky AY, Marson A, Chang HY, Bluestone JA.

Immunity. 2019 Feb 19;50(2):362-377.e6. doi: 10.1016/j.immuni.2018.12.016. Epub 2019 Jan 29.

PMID:
30709738
9.

A checkpoint on innate myeloid cells in pulmonary arterial hypertension.

Bryant AJ, Fu C, Lu Y, Brantly ML, Mehrad B, Moldawer LL, Brusko TM, Brittain EL, West JD, Austin ED, Hamid R.

Pulm Circ. 2019 Jan-Mar;9(1):2045894018823528. doi: 10.1177/2045894018823528. Epub 2018 Dec 18. No abstract available.

10.

Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells.

Choi SC, Titov AA, Abboud G, Seay HR, Brusko TM, Roopenian DC, Salek-Ardakani S, Morel L.

Nat Commun. 2018 Oct 22;9(1):4369. doi: 10.1038/s41467-018-06686-0.

11.

Immune Mechanisms and Pathways Targeted in Type 1 Diabetes.

Jacobsen LM, Newby BN, Perry DJ, Posgai AL, Haller MJ, Brusko TM.

Curr Diab Rep. 2018 Aug 30;18(10):90. doi: 10.1007/s11892-018-1066-5. Review.

PMID:
30168021
12.

Myeloid-Derived Suppressor Cells and Pulmonary Hypertension.

Bryant AJ, Mehrad B, Brusko TM, West JD, Moldawer LL.

Int J Mol Sci. 2018 Aug 3;19(8). pii: E2277. doi: 10.3390/ijms19082277. Review.

13.

Application of a Genetic Risk Score to Racially Diverse Type 1 Diabetes Populations Demonstrates the Need for Diversity in Risk-Modeling.

Perry DJ, Wasserfall CH, Oram RA, Williams MD, Posgai A, Muir AB, Haller MJ, Schatz DA, Wallet MA, Mathews CE, Atkinson MA, Brusko TM.

Sci Rep. 2018 Mar 14;8(1):4529. doi: 10.1038/s41598-018-22574-5.

14.

Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization.

Fuchs A, Gliwiński M, Grageda N, Spiering R, Abbas AK, Appel S, Bacchetta R, Battaglia M, Berglund D, Blazar B, Bluestone JA, Bornhäuser M, Ten Brinke A, Brusko TM, Cools N, Cuturi MC, Geissler E, Giannoukakis N, Gołab K, Hafler DA, van Ham SM, Hester J, Hippen K, Di Ianni M, Ilic N, Isaacs J, Issa F, Iwaszkiewicz-Grześ D, Jaeckel E, Joosten I, Klatzmann D, Koenen H, van Kooten C, Korsgren O, Kretschmer K, Levings M, Marek-Trzonkowska NM, Martinez-Llordella M, Miljkovic D, Mills KHG, Miranda JP, Piccirillo CA, Putnam AL, Ritter T, Roncarolo MG, Sakaguchi S, Sánchez-Ramón S, Sawitzki B, Sofronic-Milosavljevic L, Sykes M, Tang Q, Vives-Pi M, Waldmann H, Witkowski P, Wood KJ, Gregori S, Hilkens CMU, Lombardi G, Lord P, Martinez-Caceres EM, Trzonkowski P.

Front Immunol. 2018 Jan 15;8:1844. doi: 10.3389/fimmu.2017.01844. eCollection 2017.

15.

Avidity and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing De Novo Autoreactive T-Cell Receptors in Type 1 Diabetes.

Yeh WI, Seay HR, Newby B, Posgai AL, Moniz FB, Michels A, Mathews CE, Bluestone JA, Brusko TM.

Front Immunol. 2017 Oct 26;8:1313. doi: 10.3389/fimmu.2017.01313. eCollection 2017.

16.

Isogenic Cellular Systems Model the Impact of Genetic Risk Variants in the Pathogenesis of Type 1 Diabetes.

Wallet MA, Santostefano KE, Terada N, Brusko TM.

Front Endocrinol (Lausanne). 2017 Oct 18;8:276. doi: 10.3389/fendo.2017.00276. eCollection 2017. Review.

17.

T Cell Receptor Profiling in Type 1 Diabetes.

Jacobsen LM, Posgai A, Seay HR, Haller MJ, Brusko TM.

Curr Diab Rep. 2017 Oct 11;17(11):118. doi: 10.1007/s11892-017-0946-4. Review.

18.

T cells display mitochondria hyperpolarization in human type 1 diabetes.

Chen J, Chernatynskaya AV, Li JW, Kimbrell MR, Cassidy RJ, Perry DJ, Muir AB, Atkinson MA, Brusko TM, Mathews CE.

Sci Rep. 2017 Sep 7;7(1):10835. doi: 10.1038/s41598-017-11056-9.

19.

Type 1 Interferons Potentiate Human CD8+ T-Cell Cytotoxicity Through a STAT4- and Granzyme B-Dependent Pathway.

Newby BN, Brusko TM, Zou B, Atkinson MA, Clare-Salzler M, Mathews CE.

Diabetes. 2017 Dec;66(12):3061-3071. doi: 10.2337/db17-0106. Epub 2017 Sep 6.

20.

Regulatory T-cells from pancreatic lymphnodes of patients with type-1 diabetes express increased levels of microRNA miR-125a-5p that limits CCR2 expression.

Sebastiani G, Ventriglia G, Stabilini A, Socci C, Morsiani C, Laurenzi A, Nigi L, Formichi C, Mfarrej B, Petrelli A, Fousteri G, Brusko TM, Dotta F, Battaglia M.

Sci Rep. 2017 Jul 31;7(1):6897. doi: 10.1038/s41598-017-07172-1.

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