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New insights into apoptosome structure and function.

Dorstyn L, Akey CW, Kumar S.

Cell Death Differ. 2018 Jul;25(7):1194-1208. doi: 10.1038/s41418-017-0025-z. Epub 2018 May 15. Review.


Integrative structure and functional anatomy of a nuclear pore complex.

Kim SJ, Fernandez-Martinez J, Nudelman I, Shi Y, Zhang W, Raveh B, Herricks T, Slaughter BD, Hogan JA, Upla P, Chemmama IE, Pellarin R, Echeverria I, Shivaraju M, Chaudhury AS, Wang J, Williams R, Unruh JR, Greenberg CH, Jacobs EY, Yu Z, de la Cruz MJ, Mironska R, Stokes DL, Aitchison JD, Jarrold MF, Gerton JL, Ludtke SJ, Akey CW, Chait BT, Sali A, Rout MP.

Nature. 2018 Mar 22;555(7697):475-482. doi: 10.1038/nature26003. Epub 2018 Mar 14.


Oxidized or Reduced Cytochrome c and Axial Ligand Variants All Form the Apoptosome in Vitro.

Mendez DL, Akey IV, Akey CW, Kranz RG.

Biochemistry. 2017 Jun 6;56(22):2766-2769. doi: 10.1021/acs.biochem.7b00309. Epub 2017 May 19.


A Near-Atomic Structure of the Dark Apoptosome Provides Insight into Assembly and Activation.

Cheng TC, Akey IV, Yuan S, Yu Z, Ludtke SJ, Akey CW.

Structure. 2017 Jan 3;25(1):40-52. doi: 10.1016/j.str.2016.11.002. Epub 2016 Dec 1.


A near atomic structure of the active human apoptosome.

Cheng TC, Hong C, Akey IV, Yuan S, Akey CW.

Elife. 2016 Oct 4;5. pii: e17755. doi: 10.7554/eLife.17755.


Structure of the SecY channel during initiation of protein translocation.

Park E, Ménétret JF, Gumbart JC, Ludtke SJ, Li W, Whynot A, Rapoport TA, Akey CW.

Nature. 2014 Feb 6;506(7486):102-6. doi: 10.1038/nature12720. Epub 2013 Oct 23.


Tango7 directs cellular remodeling by the Drosophila apoptosome.

D'Brot A, Chen P, Vaishnav M, Yuan S, Akey CW, Abrams JM.

Genes Dev. 2013 Aug 1;27(15):1650-5. doi: 10.1101/gad.219287.113.


IcmQ in the Type 4b secretion system contains an NAD+ binding domain.

Farelli JD, Gumbart JC, Akey IV, Hempstead A, Amyot W, Head JF, McKnight CJ, Isberg RR, Akey CW.

Structure. 2013 Aug 6;21(8):1361-73. doi: 10.1016/j.str.2013.05.017. Epub 2013 Jul 11.


Apoptosome structure, assembly, and procaspase activation.

Yuan S, Akey CW.

Structure. 2013 Apr 2;21(4):501-15. doi: 10.1016/j.str.2013.02.024. Review.


Changes in Apaf-1 conformation that drive apoptosome assembly.

Yuan S, Topf M, Reubold TF, Eschenburg S, Akey CW.

Biochemistry. 2013 Apr 2;52(13):2319-27. doi: 10.1021/bi301721g. Epub 2013 Mar 22.


Crystal structure and function of human nucleoplasmin (npm2): a histone chaperone in oocytes and embryos.

Platonova O, Akey IV, Head JF, Akey CW.

Biochemistry. 2011 Sep 20;50(37):8078-89. doi: 10.1021/bi2006652. Epub 2011 Aug 24.


The holo-apoptosome: activation of procaspase-9 and interactions with caspase-3.

Yuan S, Yu X, Asara JM, Heuser JE, Ludtke SJ, Akey CW.

Structure. 2011 Aug 10;19(8):1084-96. doi: 10.1016/j.str.2011.07.001.


Structure of the Drosophila apoptosome at 6.9 å resolution.

Yuan S, Yu X, Topf M, Dorstyn L, Kumar S, Ludtke SJ, Akey CW.

Structure. 2011 Jan 12;19(1):128-40. doi: 10.1016/j.str.2010.10.009.


The NPC-transporter, a ghost in the machine.

Akey CW.

Structure. 2010 Oct 13;18(10):1230-2. doi: 10.1016/j.str.2010.09.005.


Structure of an apoptosome-procaspase-9 CARD complex.

Yuan S, Yu X, Topf M, Ludtke SJ, Wang X, Akey CW.

Structure. 2010 May 12;18(5):571-83. doi: 10.1016/j.str.2010.04.001.


Structure and function of interacting IcmR-IcmQ domains from a type IVb secretion system in Legionella pneumophila.

Raychaudhury S, Farelli JD, Montminy TP, Matthews M, Ménétret JF, Duménil G, Roy CR, Head JF, Isberg RR, Akey CW.

Structure. 2009 Apr 15;17(4):590-601. doi: 10.1016/j.str.2009.02.011.


Single copies of Sec61 and TRAP associate with a nontranslating mammalian ribosome.

Ménétret JF, Hegde RS, Aguiar M, Gygi SP, Park E, Rapoport TA, Akey CW.

Structure. 2008 Jul;16(7):1126-37. doi: 10.1016/j.str.2008.05.003.


Structure of the mammalian 80S ribosome at 8.7 A resolution.

Chandramouli P, Topf M, Ménétret JF, Eswar N, Cannone JJ, Gutell RR, Sali A, Akey CW.

Structure. 2008 Apr;16(4):535-48. doi: 10.1016/j.str.2008.01.007.


Ribosome binding of a single copy of the SecY complex: implications for protein translocation.

Ménétret JF, Schaletzky J, Clemons WM Jr, Osborne AR, Skånland SS, Denison C, Gygi SP, Kirkpatrick DS, Park E, Ludtke SJ, Rapoport TA, Akey CW.

Mol Cell. 2007 Dec 28;28(6):1083-92.


Three-dimensional structure of a double apoptosome formed by the Drosophila Apaf-1 related killer.

Yu X, Wang L, Acehan D, Wang X, Akey CW.

J Mol Biol. 2006 Jan 20;355(3):577-89. Epub 2005 Nov 8.


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