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Items: 1 to 20 of 270


Chronic myeloid leukemia stem cells and molecular target therapies for overcoming resistance and disease persistence.

Inoue A, Kobayashi CI, Shinohara H, Miyamoto K, Yamauchi N, Yuda J, Akao Y, Minami Y.

Int J Hematol. 2018 Oct;108(4):365-370. doi: 10.1007/s12185-018-2519-y. Epub 2018 Aug 28. Review.


Enhanced Intercellular Delivery of cRGD-siRNA Conjugates by an Additional Oligospermine Modification.

Nakamoto K, Akao Y, Furuichi Y, Ueno Y.

ACS Omega. 2018 Jul 31;3(7):8226-8232. doi: 10.1021/acsomega.8b00850. Epub 2018 Jul 24.


A Panel of MicroRNA Signature as a Tool for Predicting Survival of Patients with Urothelial Carcinoma of the Bladder.

Inamoto T, Uehara H, Akao Y, Ibuki N, Komura K, Takahara K, Takai T, Uchimoto T, Saito K, Tanda N, Yoshikawa Y, Minami K, Hirano H, Nomi H, Kato R, Hayashi T, Azuma H.

Dis Markers. 2018 Jun 20;2018:5468672. doi: 10.1155/2018/5468672. eCollection 2018.


Diazirine-containing tag-free RNA probes for efficient RISC-loading and photoaffinity labeling of microRNA targets.

Nakamoto K, Akao Y, Ueno Y.

Bioorg Med Chem Lett. 2018 Sep 15;28(17):2906-2909. doi: 10.1016/j.bmcl.2018.07.020. Epub 2018 Jul 11.


DEAD-Box Protein RNA-Helicase DDX6 Regulates the Expression of HER2 and FGFR2 at the Post-Transcriptional Step in Gastric Cancer Cells.

Tajirika T, Tokumaru Y, Taniguchi K, Sugito N, Matsuhashi N, Futamura M, Yanagihara K, Akao Y, Yoshida K.

Int J Mol Sci. 2018 Jul 9;19(7). pii: E2005. doi: 10.3390/ijms19072005.


Organ-Specific MicroRNAs (MIR122, 137, and 206) Contribute to Tissue Characteristics and Carcinogenesis by Regulating Pyruvate Kinase M1/2 (PKM) Expression.

Taniguchi K, Sugito N, Shinohara H, Kuranaga Y, Inomata Y, Komura K, Uchiyama K, Akao Y.

Int J Mol Sci. 2018 Apr 24;19(5). pii: E1276. doi: 10.3390/ijms19051276.


Development and endoscopic appearance of colorectal tumors are characterized by the expression profiles of miRNAs.

Nakagawa Y, Akao Y, Tahara T, Yamashita H, Nagasaka M, Shibata T, Ohmiya N.

Med Mol Morphol. 2018 Jun;51(2):82-88. doi: 10.1007/s00795-018-0186-y. Epub 2018 Mar 21. Review.


Impairment of K-Ras signaling networks and increased efficacy of epidermal growth factor receptor inhibitors by a novel synthetic miR-143.

Akao Y, Kumazaki M, Shinohara H, Sugito N, Kuranaga Y, Tsujino T, Yoshikawa Y, Kitade Y.

Cancer Sci. 2018 May;109(5):1455-1467. doi: 10.1111/cas.13559. Epub 2018 Apr 14.


Oncogene RNA helicase DDX6 promotes the process of c-Myc expression in gastric cancer cells.

Taniguchi K, Iwatsuki A, Sugito N, Shinohara H, Kuranaga Y, Oshikawa Y, Tajirika T, Futamura M, Yoshida K, Uchiyama K, Akao Y.

Mol Carcinog. 2018 May;57(5):579-589. doi: 10.1002/mc.22781. Epub 2018 Jan 30.


Introduction of 2-O-benzyl abasic nucleosides to the 3'-overhang regions of siRNAs greatly improves nuclease resistance.

Nagaya Y, Kitamura Y, Shibata A, Ikeda M, Akao Y, Kitade Y.

Bioorg Med Chem Lett. 2017 Dec 15;27(24):5454-5456. doi: 10.1016/j.bmcl.2017.10.070. Epub 2017 Oct 28.


Cancer-Specific Energy Metabolism in Rhabdomyosarcoma Cells Is Regulated by MicroRNA.

Sugito N, Taniguchi K, Kuranaga Y, Ohishi M, Soga T, Ito Y, Miyachi M, Kikuchi K, Hosoi H, Akao Y.

Nucleic Acid Ther. 2017 Dec;27(6):365-377. doi: 10.1089/nat.2017.0673. Epub 2017 Oct 5.


Differentiation of black writing ink on paper using luminescence lifetime by time-resolved luminescence spectroscopy.

Suzuki M, Akiba N, Kurosawa K, Akao Y, Higashikawa Y.

Forensic Sci Int. 2017 Oct;279:281-287. doi: 10.1016/j.forsciint.2017.09.003. Epub 2017 Sep 11.


Regulated Polarization of Tumor-Associated Macrophages by miR-145 via Colorectal Cancer-Derived Extracellular Vesicles.

Shinohara H, Kuranaga Y, Kumazaki M, Sugito N, Yoshikawa Y, Takai T, Taniguchi K, Ito Y, Akao Y.

J Immunol. 2017 Aug 15;199(4):1505-1515. doi: 10.4049/jimmunol.1700167. Epub 2017 Jul 10.


Circulating microRNA-214 and -126 as potential biomarkers for canine neoplastic disease.

Heishima K, Ichikawa Y, Yoshida K, Iwasaki R, Sakai H, Nakagawa T, Tanaka Y, Hoshino Y, Okamura Y, Murakami M, Maruo K, Akao Y, Mori T.

Sci Rep. 2017 May 23;7(1):2301. doi: 10.1038/s41598-017-02607-1.


MiR-145 negatively regulates Warburg effect by silencing KLF4 and PTBP1 in bladder cancer cells.

Minami K, Taniguchi K, Sugito N, Kuranaga Y, Inamoto T, Takahara K, Takai T, Yoshikawa Y, Kiyama S, Akao Y, Azuma H.

Oncotarget. 2017 May 16;8(20):33064-33077. doi: 10.18632/oncotarget.16524.


A Novel Combination RNAi toward Warburg Effect by Replacement with miR-145 and Silencing of PTBP1 Induces Apoptotic Cell Death in Bladder Cancer Cells.

Takai T, Yoshikawa Y, Inamoto T, Minami K, Taniguchi K, Sugito N, Kuranaga Y, Shinohara H, Kumazaki M, Tsujino T, Takahara K, Ito Y, Akao Y, Azuma H.

Int J Mol Sci. 2017 Jan 17;18(1). pii: E179. doi: 10.3390/ijms18010179.


A Novel Role of Dickkopf-Related Protein 3 in Macropinocytosis in Human Bladder Cancer T24 Cells.

Tsujimura N, Yamada NO, Kuranaga Y, Kumazaki M, Shinohara H, Taniguchi K, Akao Y.

Int J Mol Sci. 2016 Nov 5;17(11). pii: E1846.


MiR-133b inhibits growth of human gastric cancer cells by silencing pyruvate kinase muscle-splicer polypyrimidine tract-binding protein 1.

Sugiyama T, Taniguchi K, Matsuhashi N, Tajirika T, Futamura M, Takai T, Akao Y, Yoshida K.

Cancer Sci. 2016 Dec;107(12):1767-1775. doi: 10.1111/cas.13091. Epub 2016 Dec 19.


Perturbation of the Warburg effect increases the sensitivity of cancer cells to TRAIL-induced cell death.

Kumazaki M, Shinohara H, Taniguchi K, Takai T, Kuranaga Y, Sugito N, Akao Y.

Exp Cell Res. 2016 Sep 10;347(1):133-42. doi: 10.1016/j.yexcr.2016.07.022. Epub 2016 Jul 21.


Labeling of target mRNAs using a photo-reactive microRNA probe.

Nakamoto K, Minami K, Akao Y, Ueno Y.

Chem Commun (Camb). 2016 May 10;52(40):6720-2. doi: 10.1039/c6cc01360k.


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