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Items: 13


Methods to Detect Loss of Lysosomal Membrane Integrity.

Aits S.

Methods Mol Biol. 2019;1880:315-329. doi: 10.1007/978-1-4939-8873-0_21.


Discovery of Small Molecules That Induce Lysosomal Cell Death in Cancer Cell Lines Using an Image-Based Screening Platform.

Pagliero RJ, D'Astolfo DS, Lelieveld D, Pratiwi RD, Aits S, Jaattela M, Martin NI, Klumperman J, Egan DA.

Assay Drug Dev Technol. 2016 Oct;14(8):489-510. Epub 2016 Sep 22.


Sensitive detection of lysosomal membrane permeabilization by lysosomal galectin puncta assay.

Aits S, Kricker J, Liu B, Ellegaard AM, Hämälistö S, Tvingsholm S, Corcelle-Termeau E, Høgh S, Farkas T, Holm Jonassen A, Gromova I, Mortensen M, Jäättelä M.

Autophagy. 2015;11(8):1408-24. doi: 10.1080/15548627.2015.1063871.


Methods for the quantification of lysosomal membrane permeabilization: a hallmark of lysosomal cell death.

Aits S, Jäättelä M, Nylandsted J.

Methods Cell Biol. 2015;126:261-85. doi: 10.1016/bs.mcb.2014.10.032. Epub 2015 Jan 14.


Lysosomal cell death at a glance.

Aits S, Jäättelä M.

J Cell Sci. 2013 May 1;126(Pt 9):1905-12. doi: 10.1242/jcs.091181. Review.


Identification of cytoskeleton-associated proteins essential for lysosomal stability and survival of human cancer cells.

Groth-Pedersen L, Aits S, Corcelle-Termeau E, Petersen NH, Nylandsted J, Jäättelä M.

PLoS One. 2012;7(10):e45381. doi: 10.1371/journal.pone.0045381. Epub 2012 Oct 11.


Conserved features of cancer cells define their sensitivity to HAMLET-induced death; c-Myc and glycolysis.

Storm P, Aits S, Puthia MK, Urbano A, Northen T, Powers S, Bowen B, Chao Y, Reindl W, Lee DY, Sullivan NL, Zhang J, Trulsson M, Yang H, Watson JD, Svanborg C.

Oncogene. 2011 Dec 1;30(48):4765-79. doi: 10.1038/onc.2011.196. Epub 2011 Jun 6.


HAMLET binding to α-actinin facilitates tumor cell detachment.

Trulsson M, Yu H, Gisselsson L, Chao Y, Urbano A, Aits S, Mossberg AK, Svanborg C.

PLoS One. 2011 Mar 8;6(3):e17179. doi: 10.1371/journal.pone.0017179.


Changes in proteasome structure and function caused by HAMLET in tumor cells.

Gustafsson L, Aits S, Onnerfjord P, Trulsson M, Storm P, Svanborg C.

PLoS One. 2009;4(4):e5229. doi: 10.1371/journal.pone.0005229. Epub 2009 Apr 14.


HAMLET (human alpha-lactalbumin made lethal to tumor cells) triggers autophagic tumor cell death.

Aits S, Gustafsson L, Hallgren O, Brest P, Gustafsson M, Trulsson M, Mossberg AK, Simon HU, Mograbi B, Svanborg C.

Int J Cancer. 2009 Mar 1;124(5):1008-19. doi: 10.1002/ijc.24076.


Can misfolded proteins be beneficial? The HAMLET case.

Pettersson-Kastberg J, Aits S, Gustafsson L, Mossberg A, Storm P, Trulsson M, Persson F, Mok KH, Svanborg C.

Ann Med. 2009;41(3):162-76. doi: 10.1080/07853890802502614. Review.


Recurrent and multiple bladder tumors show conserved expression profiles.

Lindgren D, Gudjonsson S, Jee KJ, Liedberg F, Aits S, Andersson A, Chebil G, Borg A, Knuutila S, Fioretos T, Månsson W, Höglund M.

BMC Cancer. 2008 Jun 30;8:183. doi: 10.1186/1471-2407-8-183.


Apoptosis and tumor cell death in response to HAMLET (human alpha-lactalbumin made lethal to tumor cells).

Hallgren O, Aits S, Brest P, Gustafsson L, Mossberg AK, Wullt B, Svanborg C.

Adv Exp Med Biol. 2008;606:217-40. doi: 10.1007/978-0-387-74087-4_8. Review.


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