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Bull Exp Biol Med. 2002 Feb;133(2):125-6.

Activation of cannabinoid receptors decreases the area of ischemic myocardial necrosis.

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Tomsk State Pedagogical University.


We studied the possibility of decreasing the area of ischemic necrosis during myocardial infarction with HU-210, a selective cannabinoid receptor agonist. Activation of cannabinoid receptors with HU-210 had practically no effect on collateral blood flow in the myocardium, but considerably decreased the area of necrosis. There results indicate that cannabinoid receptor agonist HU-210 possesses cardioprotective activity and delays the formation of necrotic zones during coronary occlusion and reperfusion.

[Indexed for MEDLINE]

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