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Items: 1 to 20 of 165

1.

Mutation update on ACAT1 variants associated with mitochondrial acetoacetyl-CoA thiolase (T2) deficiency.

Abdelkreem E, Harijan RK, Yamaguchi S, Wierenga RK, Fukao T.

Hum Mutat. 2019 Oct;40(10):1641-1663. doi: 10.1002/humu.23831. Epub 2019 Jul 3.

2.

Complementary substrate specificity and distinct quaternary assembly of the Escherichia coli aerobic and anaerobic β-oxidation trifunctional enzyme complexes.

Sah-Teli SK, Hynönen MJ, Schmitz W, Geraets JA, Seitsonen J, Pedersen JS, Butcher SJ, Wierenga RK, Venkatesan R.

Biochem J. 2019 Jul 15;476(13):1975-1994. doi: 10.1042/BCJ20190314.

PMID:
31235482
3.

The peroxisomal zebrafish SCP2-thiolase (type-1) is a weak transient dimer as revealed by crystal structures and native mass spectrometry.

Kiema TR, Thapa CJ, Laitaoja M, Schmitz W, Maksimainen MM, Fukao T, Rouvinen J, Jänis J, Wierenga RK.

Biochem J. 2019 Jan 25;476(2):307-332. doi: 10.1042/BCJ20180788.

PMID:
30573650
4.

Structural enzymology binding studies of the peptide-substrate-binding domain of human collagen prolyl 4-hydroxylase (type-II): High affinity peptides have a PxGP sequence motif.

Murthy AV, Sulu R, Koski MK, Tu H, Anantharajan J, Sah-Teli SK, Myllyharju J, Wierenga RK.

Protein Sci. 2018 Sep;27(9):1692-1703. doi: 10.1002/pro.3450.

5.

Crystal structure of human anterior gradient protein 3.

Nguyen VD, Biterova E, Salin M, Wierenga RK, Ruddock LW.

Acta Crystallogr F Struct Biol Commun. 2018 Jul 1;74(Pt 7):425-430. doi: 10.1107/S2053230X18009093. Epub 2018 Jun 26.

PMID:
29969106
6.

De novo biosynthesis of sterols and fatty acids in the Trypanosoma brucei procyclic form: Carbon source preferences and metabolic flux redistributions.

Millerioux Y, Mazet M, Bouyssou G, Allmann S, Kiema TR, Bertiaux E, Fouillen L, Thapa C, Biran M, Plazolles N, Dittrich-Domergue F, Crouzols A, Wierenga RK, Rotureau B, Moreau P, Bringaud F.

PLoS Pathog. 2018 May 29;14(5):e1007116. doi: 10.1371/journal.ppat.1007116. eCollection 2018 May.

7.

Structural enzymology comparisons of multifunctional enzyme, type-1 (MFE1): the flexibility of its dehydrogenase part.

Kasaragod P, Midekessa GB, Sridhar S, Schmitz W, Kiema TR, Hiltunen JK, Wierenga RK.

FEBS Open Bio. 2017 Nov 6;7(12):1830-1842. doi: 10.1002/2211-5463.12337. eCollection 2017 Dec.

8.

The EMBO biocatalysis conference "The biochemistry and chemistry of biocatalysis: from understanding to design".

Wierenga RK, Ringe D.

Protein Eng Des Sel. 2017 Apr 24:1. doi: 10.1093/protein/gzx020. [Epub ahead of print] No abstract available.

PMID:
28444392
9.

Assembly of the elongated collagen prolyl 4-hydroxylase α2β2 heterotetramer around a central α2 dimer.

Koski MK, Anantharajan J, Kursula P, Dhavala P, Murthy AV, Bergmann U, Myllyharju J, Wierenga RK.

Biochem J. 2017 Feb 20;474(5):751-769. doi: 10.1042/BCJ20161000.

PMID:
28093469
10.

Crystallographic substrate binding studies of Leishmania mexicana SCP2-thiolase (type-2): unique features of oxyanion hole-1.

Harijan RK, Kiema TR, Syed SM, Qadir I, Mazet M, Bringaud F, Michels PAM, Wierenga RK.

Protein Eng Des Sel. 2017 Mar 1;30(3):225-233. doi: 10.1093/protein/gzw080.

PMID:
28062645
11.

Crystal structure of a thiolase from Escherichia coli at 1.8 Å resolution.

Ithayaraja M, Janardan N, Wierenga RK, Savithri HS, Murthy MR.

Acta Crystallogr F Struct Biol Commun. 2016 Jul;72(Pt 7):534-44. doi: 10.1107/S2053230X16008451. Epub 2016 Jun 22.

12.

Crystal structures of two monomeric triosephosphate isomerase variants identified via a directed-evolution protocol selecting for L-arabinose isomerase activity.

Krause M, Kiema TR, Neubauer P, Wierenga RK.

Acta Crystallogr F Struct Biol Commun. 2016 Jun;72(Pt 6):490-9. doi: 10.1107/S2053230X16007548. Epub 2016 May 23.

13.

Structure-Function Studies of Hydrophobic Residues That Clamp a Basic Glutamate Side Chain during Catalysis by Triosephosphate Isomerase.

Richard JP, Amyes TL, Malabanan MM, Zhai X, Kim KJ, Reinhardt CJ, Wierenga RK, Drake EJ, Gulick AM.

Biochemistry. 2016 May 31;55(21):3036-47. doi: 10.1021/acs.biochem.6b00311. Epub 2016 May 17.

14.

The SCP2-thiolase-like protein (SLP) of Trypanosoma brucei is an enzyme involved in lipid metabolism.

Harijan RK, Mazet M, Kiema TR, Bouyssou G, Alexson SE, Bergmann U, Moreau P, Michels PA, Bringaud F, Wierenga RK.

Proteins. 2016 Aug;84(8):1075-96. doi: 10.1002/prot.25054. Epub 2016 May 9.

PMID:
27093562
15.

The extended structure of the periplasmic region of CdsD, a structural protein of the type III secretion system of Chlamydia trachomatis.

Meriläinen G, Koski MK, Wierenga RK.

Protein Sci. 2016 May;25(5):987-98. doi: 10.1002/pro.2906. Epub 2016 Mar 11.

16.

Structural characterization of a mitochondrial 3-ketoacyl-CoA (T1)-like thiolase from Mycobacterium smegmatis.

Janardan N, Harijan RK, Kiema TR, Wierenga RK, Murthy MR.

Acta Crystallogr D Biol Crystallogr. 2015 Dec 1;71(Pt 12):2479-93. doi: 10.1107/S1399004715019331. Epub 2015 Nov 27.

PMID:
26627655
17.

Structures of yeast peroxisomal Δ(3),Δ(2)-enoyl-CoA isomerase complexed with acyl-CoA substrate analogues: the importance of hydrogen-bond networks for the reactivity of the catalytic base and the oxyanion hole.

Onwukwe GU, Koski MK, Pihko P, Schmitz W, Wierenga RK.

Acta Crystallogr D Biol Crystallogr. 2015 Nov;71(Pt 11):2178-91. doi: 10.1107/S139900471501559X. Epub 2015 Oct 27.

PMID:
26527136
18.

ATGme: Open-source web application for rare codon identification and custom DNA sequence optimization.

Daniel E, Onwukwe GU, Wierenga RK, Quaggin SE, Vainio SJ, Krause M.

BMC Bioinformatics. 2015 Sep 21;16:303. doi: 10.1186/s12859-015-0743-5.

19.

Structure-based directed evolution of a monomeric triosephosphate isomerase: toward a pentose sugar isomerase.

Krause M, Neubauer P, Wierenga RK.

Protein Eng Des Sel. 2015 Jun;28(6):187-97. doi: 10.1093/protein/gzv010. Epub 2015 Mar 11.

PMID:
25767111
20.

Human Δ³,Δ²-enoyl-CoA isomerase, type 2: a structural enzymology study on the catalytic role of its ACBP domain and helix-10.

Onwukwe GU, Kursula P, Koski MK, Schmitz W, Wierenga RK.

FEBS J. 2015 Feb;282(4):746-68. doi: 10.1111/febs.13179. Epub 2015 Jan 14.

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