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Items: 1 to 20 of 32


Structures of a dimodular nonribosomal peptide synthetase reveal conformational flexibility.

Reimer JM, Eivaskhani M, Harb I, Guarné A, Weigt M, Schmeing TM.

Science. 2019 Nov 8;366(6466). pii: eaaw4388. doi: 10.1126/science.aaw4388.


Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid.

Huguenin-Dezot N, Alonzo DA, Heberlig GW, Mahesh M, Nguyen DP, Dornan MH, Boddy CN, Schmeing TM, Chin JW.

Nature. 2019 Jan;565(7737):112-117. doi: 10.1038/s41586-018-0781-z. Epub 2018 Dec 12.


Structural Insight into a Novel Formyltransferase and Evolution to a Nonribosomal Peptide Synthetase Tailoring Domain.

Reimer JM, Harb I, Ovchinnikova OG, Jiang J, Whitfield C, Schmeing TM.

ACS Chem Biol. 2018 Nov 16;13(11):3161-3172. doi: 10.1021/acschembio.8b00739. Epub 2018 Oct 30.


Rocaglates as dual-targeting agents for experimental cerebral malaria.

Langlais D, Cencic R, Moradin N, Kennedy JM, Ayi K, Brown LE, Crandall I, Tarry MJ, Schmeing M, Kain KC, Porco JA Jr, Pelletier J, Gros P.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2366-E2375. doi: 10.1073/pnas.1713000115. Epub 2018 Feb 20.


Piecing together nonribosomal peptide synthesis.

Reimer JM, Haque AS, Tarry MJ, Schmeing TM.

Curr Opin Struct Biol. 2018 Apr;49:104-113. doi: 10.1016/ Epub 2018 Feb 13. Review.


Structural and functional aspects of the nonribosomal peptide synthetase condensation domain superfamily: discovery, dissection and diversity.

Bloudoff K, Schmeing TM.

Biochim Biophys Acta Proteins Proteom. 2017 Nov;1865(11 Pt B):1587-1604. doi: 10.1016/j.bbapap.2017.05.010. Epub 2017 May 16. Review.


X-Ray Crystallography and Electron Microscopy of Cross- and Multi-Module Nonribosomal Peptide Synthetase Proteins Reveal a Flexible Architecture.

Tarry MJ, Haque AS, Bui KH, Schmeing TM.

Structure. 2017 May 2;25(5):783-793.e4. doi: 10.1016/j.str.2017.03.014. Epub 2017 Apr 20.


Structural and mutational analysis of the nonribosomal peptide synthetase heterocyclization domain provides insight into catalysis.

Bloudoff K, Fage CD, Marahiel MA, Schmeing TM.

Proc Natl Acad Sci U S A. 2017 Jan 3;114(1):95-100. doi: 10.1073/pnas.1614191114. Epub 2016 Dec 19.


Visualizing A Natural Antibiotic Nanofactory.

Schmeing TM.

Clin Invest Med. 2016 Dec 1;39(6):E220-E226.


Manipulation of an existing crystal form unexpectedly results in interwoven packing networks with pseudo-translational symmetry.

Reimer JM, Aloise MN, Powell HR, Schmeing TM.

Acta Crystallogr D Struct Biol. 2016 Oct 1;72(Pt 10):1130-1136. Epub 2016 Sep 20.


Chemical Probes Allow Structural Insight into the Condensation Reaction of Nonribosomal Peptide Synthetases.

Bloudoff K, Alonzo DA, Schmeing TM.

Cell Chem Biol. 2016 Mar 17;23(3):331-9. doi: 10.1016/j.chembiol.2016.02.012.


Translation: Ribosomes make sweeping arrests.

Alonzo DA, Schmeing TM.

Nat Chem Biol. 2016 Mar;12(3):127-8. doi: 10.1038/nchembio.2027. No abstract available.


Synthetic cycle of the initiation module of a formylating nonribosomal peptide synthetase.

Reimer JM, Aloise MN, Harrison PM, Schmeing TM.

Nature. 2016 Jan 14;529(7585):239-42. doi: 10.1038/nature16503.


Towards a characterization of the structural determinants of specificity in the macrocyclizing thioesterase for deoxyerythronolide B biosynthesis.

Argyropoulos P, Bergeret F, Pardin C, Reimer JM, Pinto A, Boddy CN, Schmeing TM.

Biochim Biophys Acta. 2016 Mar;1860(3):486-97. doi: 10.1016/j.bbagen.2015.11.007. Epub 2015 Nov 22.


Characterization of cereulide synthetase, a toxin-producing macromolecular machine.

Alonzo DA, Magarvey NA, Schmeing TM.

PLoS One. 2015 Jun 4;10(6):e0128569. doi: 10.1371/journal.pone.0128569. eCollection 2015.


Specific disulfide cross-linking to constrict the mobile carrier domain of nonribosomal peptide synthetases.

Tarry MJ, Schmeing TM.

Protein Eng Des Sel. 2015 Jun;28(6):163-70. doi: 10.1093/protein/gzv009. Epub 2015 Feb 23.


Protospacer adjacent motif (PAM)-distal sequences engage CRISPR Cas9 DNA target cleavage.

Cencic R, Miura H, Malina A, Robert F, Ethier S, Schmeing TM, Dostie J, Pelletier J.

PLoS One. 2014 Oct 2;9(10):e109213. doi: 10.1371/journal.pone.0109213. eCollection 2014.


Crystal structures of the first condensation domain of CDA synthetase suggest conformational changes during the synthetic cycle of nonribosomal peptide synthetases.

Bloudoff K, Rodionov D, Schmeing TM.

J Mol Biol. 2013 Sep 9;425(17):3137-50. doi: 10.1016/j.jmb.2013.06.003. Epub 2013 Jun 10.


Crystallization and preliminary crystallographic analysis of the first condensation domain of viomycin synthetase.

Bloudoff K, Schmeing TM.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Apr 1;69(Pt 4):412-5. doi: 10.1107/S1744309113004004. Epub 2013 Mar 28.


How mutations in tRNA distant from the anticodon affect the fidelity of decoding.

Schmeing TM, Voorhees RM, Kelley AC, Ramakrishnan V.

Nat Struct Mol Biol. 2011 Apr;18(4):432-6. doi: 10.1038/nsmb.2003. Epub 2011 Mar 6.

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