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Items: 1 to 20 of 502

1.

N-Thiazolylamide-based free fatty-acid 2 receptor agonists: Discovery, lead optimization and demonstration of off-target effect in a diabetes model.

Hoveyda HR, Fraser GL, Zoute L, Dutheuil G, Schils D, Brantis C, Lapin A, Parcq J, Guitard S, Lenoir F, Bousmaqui ME, Rorive S, Hospied S, Blanc S, Bernard J, Ooms F, McNelis JC, Olefsky JM.

Bioorg Med Chem. 2018 Oct 1;26(18):5169-5180. doi: 10.1016/j.bmc.2018.09.015. Epub 2018 Sep 18.

PMID:
30253886
2.

Role of Host GPR120 in Mediating Dietary Omega-3 Fatty Acid Inhibition of Prostate Cancer.

Liang P, Henning SM, Guan J, Grogan T, Elashoff D, Olefsky JM, Cohen P, Aronson WJ.

J Natl Cancer Inst. 2018 Sep 6. doi: 10.1093/jnci/djy125. [Epub ahead of print]

PMID:
30202902
3.

RalA controls glucose homeostasis by regulating glucose uptake in brown fat.

Skorobogatko Y, Dragan M, Cordon C, Reilly SM, Hung CW, Xia W, Zhao P, Wallace M, Lackey DE, Chen XW, Osborn O, Bogner-Strauss JG, Theodorescu D, Metallo CM, Olefsky JM, Saltiel AR.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):7819-7824. doi: 10.1073/pnas.1801050115. Epub 2018 Jun 18.

PMID:
29915037
4.

Chronic fractalkine administration improves glucose tolerance and pancreatic endocrine function.

Riopel M, Seo JB, Bandyopadhyay GK, Li P, Wollam J, Chung H, Jung SR, Murphy A, Wilson M, de Jong R, Patel S, Balakrishna D, Bilakovics J, Fanjul A, Plonowski A, Koh DS, Larson CJ, Olefsky JM, Lee YS.

J Clin Invest. 2018 Apr 2;128(4):1458-1470. doi: 10.1172/JCI94330. Epub 2018 Mar 5.

5.

An Integrated View of Immunometabolism.

Lee YS, Wollam J, Olefsky JM.

Cell. 2018 Jan 11;172(1-2):22-40. doi: 10.1016/j.cell.2017.12.025. Review.

PMID:
29328913
6.

Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity.

Ying W, Riopel M, Bandyopadhyay G, Dong Y, Birmingham A, Seo JB, Ofrecio JM, Wollam J, Hernandez-Carretero A, Fu W, Li P, Olefsky JM.

Cell. 2017 Oct 5;171(2):372-384.e12. doi: 10.1016/j.cell.2017.08.035. Epub 2017 Sep 21.

7.

Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling.

Ying W, Wollam J, Ofrecio JM, Bandyopadhyay G, El Ouarrat D, Lee YS, Oh DY, Li P, Osborn O, Olefsky JM.

J Clin Invest. 2017 Mar 1;127(3):1019-1030. doi: 10.1172/JCI90350. Epub 2017 Feb 13.

8.

Inflammatory mechanisms linking obesity and metabolic disease.

Saltiel AR, Olefsky JM.

J Clin Invest. 2017 Jan 3;127(1):1-4. doi: 10.1172/JCI92035. Epub 2017 Jan 3. Review.

9.

Obese Neuronal PPARγ Knockout Mice Are Leptin Sensitive but Show Impaired Glucose Tolerance and Fertility.

Fernandez MO, Sharma S, Kim S, Rickert E, Hsueh K, Hwang V, Olefsky JM, Webster NJ.

Endocrinology. 2017 Jan 1;158(1):121-133. doi: 10.1210/en.2016-1818.

10.

Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance.

Li P, Liu S, Lu M, Bandyopadhyay G, Oh D, Imamura T, Johnson AMF, Sears D, Shen Z, Cui B, Kong L, Hou S, Liang X, Iovino S, Watkins SM, Ying W, Osborn O, Wollam J, Brenner M, Olefsky JM.

Cell. 2016 Nov 3;167(4):973-984.e12. doi: 10.1016/j.cell.2016.10.025.

11.

G protein-coupled receptors as targets for anti-diabetic therapeutics.

Oh DY, Olefsky JM.

Nat Rev Drug Discov. 2016 Mar;15(3):161-72. doi: 10.1038/nrd.2015.4. Epub 2016 Jan 29. Review.

PMID:
26822831
12.

p75 Neurotrophin Receptor Regulates Energy Balance in Obesity.

Baeza-Raja B, Sachs BD, Li P, Christian F, Vagena E, Davalos D, Le Moan N, Ryu JK, Sikorski SL, Chan JP, Scadeng M, Taylor SS, Houslay MD, Baillie GS, Saltiel AR, Olefsky JM, Akassoglou K.

Cell Rep. 2016 Jan 12;14(2):255-68. doi: 10.1016/j.celrep.2015.12.028. Epub 2015 Dec 31.

13.

Regulation of metabolism by the innate immune system.

Lackey DE, Olefsky JM.

Nat Rev Endocrinol. 2016 Jan;12(1):15-28. doi: 10.1038/nrendo.2015.189. Epub 2015 Nov 10. Review.

PMID:
26553134
14.

Spatial Cognition in Adult and Aged Mice Exposed to High-Fat Diet.

Kesby JP, Kim JJ, Scadeng M, Woods G, Kado DM, Olefsky JM, Jeste DV, Achim CL, Semenova S.

PLoS One. 2015 Oct 8;10(10):e0140034. doi: 10.1371/journal.pone.0140034. eCollection 2015.

15.

GPR43 Potentiates β-Cell Function in Obesity.

McNelis JC, Lee YS, Mayoral R, van der Kant R, Johnson AM, Wollam J, Olefsky JM.

Diabetes. 2015 Sep;64(9):3203-17. doi: 10.2337/db14-1938. Epub 2015 May 28.

16.

Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity.

Mayoral R, Osborn O, McNelis J, Johnson AM, Oh DY, Izquierdo CL, Chung H, Li P, Traves PG, Bandyopadhyay G, Pessentheiner AR, Ofrecio JM, Cook JR, Qiang L, Accili D, Olefsky JM.

Mol Metab. 2015 Mar 5;4(5):378-91. doi: 10.1016/j.molmet.2015.02.007. eCollection 2015 May.

17.

High fat diet causes depletion of intestinal eosinophils associated with intestinal permeability.

Johnson AM, Costanzo A, Gareau MG, Armando AM, Quehenberger O, Jameson JM, Olefsky JM.

PLoS One. 2015 Apr 2;10(4):e0122195. doi: 10.1371/journal.pone.0122195. eCollection 2015.

18.

Corrigendum: Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer.

Suh JM, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, van Dijk TH, Havinga R, Fan W, Yin YQ, Yu RT, Liddle C, Atkins AR, Olefsky JM, Mohammadi M, Downes M, Evans RM.

Nature. 2015 Apr 16;520(7547):388. doi: 10.1038/nature14304. Epub 2015 Mar 4. No abstract available.

PMID:
25739500
19.

LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes.

Li P, Oh DY, Bandyopadhyay G, Lagakos WS, Talukdar S, Osborn O, Johnson A, Chung H, Maris M, Ofrecio JM, Taguchi S, Lu M, Olefsky JM.

Nat Med. 2015 Mar;21(3):239-247. doi: 10.1038/nm.3800. Epub 2015 Feb 23.

20.

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance.

Fang S, Suh JM, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky JM, Saltiel AR, Downes M, Evans RM.

Nat Med. 2015 Feb;21(2):159-65. doi: 10.1038/nm.3760. Epub 2015 Jan 5.

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