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Items: 1 to 20 of 59


FANCI is a negative regulator of Akt activation.

Zhang X, Lu X, Akhter S, Georgescu MM, Legerski RJ.

Cell Cycle. 2016;15(8):1134-43. doi: 10.1080/15384101.2016.1158375.


DNA damage checkpoint recovery and cancer development.

Wang H, Zhang X, Teng L, Legerski RJ.

Exp Cell Res. 2015 Jun 10;334(2):350-8. doi: 10.1016/j.yexcr.2015.03.011. Epub 2015 Apr 2. Review.


Artemis interacts with the Cul4A-DDB1DDB2 ubiquitin E3 ligase and regulates degradation of the CDK inhibitor p27.

Yan Y, Zhang X, Legerski RJ.

Cell Cycle. 2011 Dec 1;10(23):4098-109. doi: 10.4161/cc.10.23.18227. Epub 2011 Dec 1.


The telomeric protein SNM1B/Apollo is required for normal cell proliferation and embryonic development.

Akhter S, Lam YC, Chang S, Legerski RJ.

Aging Cell. 2010 Dec;9(6):1047-56. doi: 10.1111/j.1474-9726.2010.00631.x. Epub 2010 Oct 21.


Repair of DNA interstrand cross-links during S phase of the mammalian cell cycle.

Legerski RJ.

Environ Mol Mutagen. 2010 Jul;51(6):540-51. doi: 10.1002/em.20566. Review.


DNA interstrand crosslinks: repair, cell signaling, and therapeutic implications.

Vasquez KM, Legerski RJ.

Environ Mol Mutagen. 2010 Jul;51(6):491-2. doi: 10.1002/em.20598. No abstract available.


SNMIB/Apollo protects leading-strand telomeres against NHEJ-mediated repair.

Lam YC, Akhter S, Gu P, Ye J, Poulet A, Giraud-Panis MJ, Bailey SM, Gilson E, Legerski RJ, Chang S.

EMBO J. 2010 Jul 7;29(13):2230-41. doi: 10.1038/emboj.2010.58. Epub 2010 Jun 15.


DNA-PKcs regulates a single-stranded DNA endonuclease activity of Artemis.

Gu J, Li S, Zhang X, Wang LC, Niewolik D, Schwarz K, Legerski RJ, Zandi E, Lieber MR.

DNA Repair (Amst). 2010 Apr 4;9(4):429-37. doi: 10.1016/j.dnarep.2010.01.001. Epub 2010 Feb 1.


The Pso4 complex splices into the DNA damage response.

Legerski RJ.

Cell Cycle. 2009 Nov 1;8(21):3448-9. Epub 2009 Nov 10. No abstract available.


Cyclin E is stabilized in response to replication fork barriers leading to prolonged S phase arrest.

Lu X, Liu J, Legerski RJ.

J Biol Chem. 2009 Dec 18;284(51):35325-37. doi: 10.1074/jbc.M109.035949.


Cdc5L interacts with ATR and is required for the S-phase cell-cycle checkpoint.

Zhang N, Kaur R, Akhter S, Legerski RJ.

EMBO Rep. 2009 Sep;10(9):1029-35. doi: 10.1038/embor.2009.122. Epub 2009 Jul 24.


Artemis regulates cell cycle recovery from the S phase checkpoint by promoting degradation of cyclin E.

Wang H, Zhang X, Geng L, Teng L, Legerski RJ.

J Biol Chem. 2009 Jul 3;284(27):18236-43. doi: 10.1074/jbc.M109.002584. Epub 2009 May 7.


Artemis is a negative regulator of p53 in response to oxidative stress.

Zhang X, Zhu Y, Geng L, Wang H, Legerski RJ.

Oncogene. 2009 Jun 4;28(22):2196-204. doi: 10.1038/onc.2009.100. Epub 2009 Apr 27.


SNM1A acts downstream of ATM to promote the G1 cell cycle checkpoint.

Akhter S, Legerski RJ.

Biochem Biophys Res Commun. 2008 Dec 5;377(1):236-41. doi: 10.1016/j.bbrc.2008.09.130. Epub 2008 Oct 9.


Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links.

Bae JB, Mukhopadhyay SS, Liu L, Zhang N, Tan J, Akhter S, Liu X, Shen X, Li L, Legerski RJ.

Oncogene. 2008 Aug 28;27(37):5045-56. doi: 10.1038/onc.2008.139. Epub 2008 May 12.


The Prp19/Pso4 core complex undergoes ubiquitylation and structural alterations in response to DNA damage.

Lu X, Legerski RJ.

Biochem Biophys Res Commun. 2007 Mar 23;354(4):968-74. Epub 2007 Jan 26.


Artemis links ATM to G2/M checkpoint recovery via regulation of Cdk1-cyclin B.

Geng L, Zhang X, Zheng S, Legerski RJ.

Mol Cell Biol. 2007 Apr;27(7):2625-35. Epub 2007 Jan 22.


Repair of DNA interstrand cross-links: interactions between homology-dependent and homology-independent pathways.

Zheng H, Wang X, Legerski RJ, Glazer PM, Li L.

DNA Repair (Amst). 2006 May 10;5(5):566-74. Epub 2006 Mar 29.


Snm1-deficient mice exhibit accelerated tumorigenesis and susceptibility to infection.

Ahkter S, Richie CT, Zhang N, Behringer RR, Zhu C, Legerski RJ.

Mol Cell Biol. 2005 Nov;25(22):10071-8.


The Pso4 mRNA splicing and DNA repair complex interacts with WRN for processing of DNA interstrand cross-links.

Zhang N, Kaur R, Lu X, Shen X, Li L, Legerski RJ.

J Biol Chem. 2005 Dec 9;280(49):40559-67. Epub 2005 Oct 12.

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