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Hypothalamic Leptin Gene Therapy Reduces Bone Marrow Adiposity in ob/ob Mice Fed Regular and High-Fat Diets.

Lindenmaier LB, Philbrick KA, Branscum AJ, Kalra SP, Turner RT, Iwaniec UT.

Front Endocrinol (Lausanne). 2016 Aug 16;7:110. doi: 10.3389/fendo.2016.00110. eCollection 2016.


Hypothalamic leptin gene therapy reduces body weight without accelerating age-related bone loss.

Turner RT, Dube M, Branscum AJ, Wong CP, Olson DA, Zhong X, Kweh MF, Larkin IV, Wronski TJ, Rosen CJ, Kalra SP, Iwaniec UT.

J Endocrinol. 2015 Dec;227(3):129-41. doi: 10.1530/JOE-15-0280. Epub 2015 Oct 20.


Should leptin replace insulin as a lifetime monotherapy for diabetes type 1 and 2?

Kalra SP.

Indian J Endocrinol Metab. 2013 Oct;17(Suppl 1):S23-4. doi: 10.4103/2230-8210.119496. Review.


A case for new therapy for diabetes, is it leptin?

Kalra SP.

Indian J Endocrinol Metab. 2012 Dec;16(Suppl 3):S525-8. doi: 10.4103/2230-8210.105566. No abstract available.


Peripheral leptin regulates bone formation.

Turner RT, Kalra SP, Wong CP, Philbrick KA, Lindenmaier LB, Boghossian S, Iwaniec UT.

J Bone Miner Res. 2013 Jan;28(1):22-34. doi: 10.1002/jbmr.1734.


Effects of increased hypothalamic leptin gene expression on ovariectomy-induced bone loss in rats.

Jackson MA, Iwaniec UT, Turner RT, Wronski TJ, Kalra SP.

Peptides. 2011 Aug;32(8):1575-80. doi: 10.1016/j.peptides.2011.04.029. Epub 2011 May 27.


Hypothalamic leptin gene therapy prevents weight gain without long-term detrimental effects on bone in growing and skeletally mature female rats.

Iwaniec UT, Boghossian S, Trevisiol CH, Wronski TJ, Turner RT, Kalra SP.

J Bone Miner Res. 2011 Jul;26(7):1506-16. doi: 10.1002/jbmr.365.


Pivotal role of leptin-hypothalamus signaling in the etiology of diabetes uncovered by gene therapy: a new therapeutic intervention?

Kalra SP.

Gene Ther. 2011 Apr;18(4):319-25. doi: 10.1038/gt.2010.164. Epub 2011 Jan 6. Review.


Neuroendocrine control of energy homeostasis: update on new insights.

Kalra SP, Kalra PS.

Prog Brain Res. 2010;181:17-33. doi: 10.1016/S0079-6123(08)81002-3. Review.


Leptin increases osteoblast-specific osteocalcin release through a hypothalamic relay.

Kalra SP, Dube MG, Iwaniec UT.

Peptides. 2009 May;30(5):967-73. doi: 10.1016/j.peptides.2009.01.020. Epub 2009 Feb 7.


Central leptin gene therapy, a substitute for insulin therapy to ameliorate hyperglycemia and hyperphagia, and promote survival in insulin-deficient diabetic mice.

Kojima S, Asakawa A, Amitani H, Sakoguchi T, Ueno N, Inui A, Kalra SP.

Peptides. 2009 May;30(5):962-6. doi: 10.1016/j.peptides.2009.01.007. Epub 2009 Jan 22.


Body mass influences cortical bone mass independent of leptin signaling.

Iwaniec UT, Dube MG, Boghossian S, Song H, Helferich WG, Turner RT, Kalra SP.

Bone. 2009 Mar;44(3):404-12. doi: 10.1016/j.bone.2008.10.058. Epub 2008 Nov 27.


Inhibition of p66ShcA redox activity in cardiac muscle cells attenuates hyperglycemia-induced oxidative stress and apoptosis.

Malhotra A, Vashistha H, Yadav VS, Dube MG, Kalra SP, Abdellatif M, Meggs LG.

Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H380-8. doi: 10.1152/ajpheart.00225.2008. Epub 2008 Dec 5.


Increased leptin expression selectively in the hypothalamus suppresses inflammatory markers CRP and IL-6 in leptin-deficient diabetic obese mice.

Dube MG, Torto R, Kalra SP.

Peptides. 2008 Apr;29(4):593-8. doi: 10.1016/j.peptides.2008.01.001. Epub 2008 Jan 17.


Central leptin gene therapy corrects skeletal abnormalities in leptin-deficient ob/ob mice.

Iwaniec UT, Boghossian S, Lapke PD, Turner RT, Kalra SP.

Peptides. 2007 May;28(5):1012-9. Epub 2007 Feb 12.


Neuroendocrine actions and regulation of hypothalamic neuropeptide Y during lactation.

Crowley WR, Ramoz G, Torto R, Keefe KA, Wang JJ, Kalra SP.

Peptides. 2007 Feb;28(2):447-52. Epub 2007 Jan 22. Review.

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