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Items: 1 to 20 of 27

1.

Acute Moraxella catarrhalis Airway Infection of Chronically Smoke-Exposed Mice Increases Mechanisms of Emphysema Development: A Pilot Study.

Fischer K, Doehn JM, Herr C, Lachner C, Heinrich A, Kershaw O, Voss M, Jacobson MH, Gruber AD, Clauss M, Witzenrath M, Bals R, Gutbier B, Slevogt H.

Eur J Microbiol Immunol (Bp). 2018 Dec 11;8(4):128-134. doi: 10.1556/1886.2018.00019. eCollection 2018 Dec 23.

2.

Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia.

Robak OH, Heimesaat MM, Kruglov AA, Prepens S, Ninnemann J, Gutbier B, Reppe K, Hochrein H, Suter M, Kirschning CJ, Marathe V, Buer J, Hornef MW, Schnare M, Schneider P, Witzenrath M, Bereswill S, Steinhoff U, Suttorp N, Sander LE, Chaput C, Opitz B.

J Clin Invest. 2018 Aug 1;128(8):3535-3545. doi: 10.1172/JCI97065. Epub 2018 Jul 16.

3.

Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia.

Gutbier B, Neuhauß AK, Reppe K, Ehrler C, Santel A, Kaufmann J, Scholz M, Weissmann N, Morawietz L, Mitchell TJ, Aliberti S, Hippenstiel S, Suttorp N, Witzenrath M; CAPNETZ and PROGRESS Study Groups ‡.

Am J Respir Crit Care Med. 2018 Jul 15;198(2):220-231. doi: 10.1164/rccm.201708-1733OC.

PMID:
29447449
4.

Digital Image Analyses on Whole-Lung Slides in Mouse Models of Acute Pneumonia.

Dietert K, Nouailles G, Gutbier B, Reppe K, Berger S, Jiang X, Schauer AE, Hocke AC, Herold S, Slevogt H, Witzenrath M, Suttorp N, Gruber AD.

Am J Respir Cell Mol Biol. 2018 Apr;58(4):440-448. doi: 10.1165/rcmb.2017-0337MA.

PMID:
29361238
5.

Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2.

Gutbier B, Schönrock SM, Ehrler C, Haberberger R, Dietert K, Gruber AD, Kummer W, Michalick L, Kuebler WM, Hocke AC, Szymanski K, Letsiou E, Lüth A, Schumacher F, Kleuser B, Mitchell TJ, Bertrams W, Schmeck B, Treue D, Klauschen F, Bauer TT, Tönnies M, Weissmann N, Hippenstiel S, Suttorp N, Witzenrath M; CAPNETZ Study Group.

Crit Care Med. 2018 Mar;46(3):e258-e267. doi: 10.1097/CCM.0000000000002916.

PMID:
29298188
6.

Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.

Dietert K, Gutbier B, Wienhold SM, Reppe K, Jiang X, Yao L, Chaput C, Naujoks J, Brack M, Kupke A, Peteranderl C, Becker S, von Lachner C, Baal N, Slevogt H, Hocke AC, Witzenrath M, Opitz B, Herold S, Hackstein H, Sander LE, Suttorp N, Gruber AD.

PLoS One. 2017 Nov 20;12(11):e0188251. doi: 10.1371/journal.pone.0188251. eCollection 2017.

7.

Vasculotide reduces pulmonary hyperpermeability in experimental pneumococcal pneumonia.

Gutbier B, Jiang X, Dietert K, Ehrler C, Lienau J, Van Slyke P, Kim H, Hoang VC, Maynes JT, Dumont DJ, Gruber AD, Weissmann N, Mitchell TJ, Suttorp N, Witzenrath M.

Crit Care. 2017 Nov 13;21(1):274. doi: 10.1186/s13054-017-1851-6.

8.

NLRP3 protects alveolar barrier integrity by an inflammasome-independent increase of epithelial cell adherence.

Kostadinova E, Chaput C, Gutbier B, Lippmann J, Sander LE, Mitchell TJ, Suttorp N, Witzenrath M, Opitz B.

Sci Rep. 2016 Aug 1;6:30943. doi: 10.1038/srep30943.

9.

Moraxella catarrhalis induces an immune response in the murine lung that is independent of human CEACAM5 expression and long-term smoke exposure.

Gutbier B, Fischer K, Doehn JM, von Lachner C, Herr C, Klaile E, Frischmann U, Singer BB, Riesbeck K, Zimmermann W, Suttorp N, Bachmann S, Bals R, Witzenrath M, Slevogt H.

Am J Physiol Lung Cell Mol Physiol. 2015 Aug 1;309(3):L250-61. doi: 10.1152/ajplung.00265.2014. Epub 2015 Jun 5.

10.

CFTR and sphingolipids mediate hypoxic pulmonary vasoconstriction.

Tabeling C, Yu H, Wang L, Ranke H, Goldenberg NM, Zabini D, Noe E, Krauszman A, Gutbier B, Yin J, Schaefer M, Arenz C, Hocke AC, Suttorp N, Proia RL, Witzenrath M, Kuebler WM.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1614-23. doi: 10.1073/pnas.1421190112. Epub 2015 Mar 17.

11.

Moxifloxacin is not anti-inflammatory in experimental pneumococcal pneumonia.

Müller-Redetzky HC, Wienhold SM, Berg J, Hocke AC, Hippenstiel S, Hellwig K, Gutbier B, Opitz B, Neudecker J, Rückert J, Gruber AD, Kershaw O, Mayer K, Suttorp N, Witzenrath M.

J Antimicrob Chemother. 2015 Mar;70(3):830-40. doi: 10.1093/jac/dku446. Epub 2014 Nov 17.

PMID:
25406299
12.

Surfactant protein A mediates pulmonary clearance of Staphylococcus aureus.

Veith NT, Tschernig T, Gutbier B, Witzenrath M, Meier C, Menger M, Bischoff M.

Respir Res. 2014 Aug 5;15:85. doi: 10.1186/s12931-014-0085-2.

13.

Nucleotide oligomerization domain 1 ligation suppressed murine allergen-specific T-cell proliferation and airway hyperresponsiveness.

Tabeling C, Scheer H, Schönrock SM, Runge F, Gutbier B, Lienau J, Hamelmann E, Opitz B, Suttorp N, Mayer K, Behrens GM, Tschernig T, Witzenrath M.

Am J Respir Cell Mol Biol. 2014 May;50(5):903-11. doi: 10.1165/rcmb.2013-0333OC.

PMID:
24279792
14.

Delivery of the endolysin Cpl-1 by inhalation rescues mice with fatal pneumococcal pneumonia.

Doehn JM, Fischer K, Reppe K, Gutbier B, Tschernig T, Hocke AC, Fischetti VA, Löffler J, Suttorp N, Hippenstiel S, Witzenrath M.

J Antimicrob Chemother. 2013 Sep;68(9):2111-7. doi: 10.1093/jac/dkt131. Epub 2013 Apr 30.

PMID:
23633685
15.

Streptococcus pneumoniae-induced regulation of cyclooxygenase-2 in human lung tissue.

Szymanski KV, Toennies M, Becher A, Fatykhova D, N'Guessan PD, Gutbier B, Klauschen F, Neuschaefer-Rube F, Schneider P, Rueckert J, Neudecker J, Bauer TT, Dalhoff K, Drömann D, Gruber AD, Kershaw O, Temmesfeld-Wollbrueck B, Suttorp N, Hippenstiel S, Hocke AC.

Eur Respir J. 2012 Dec;40(6):1458-67. doi: 10.1183/09031936.00186911. Epub 2012 Mar 22.

16.

Streptococcus pneumoniae stimulates a STING- and IFN regulatory factor 3-dependent type I IFN production in macrophages, which regulates RANTES production in macrophages, cocultured alveolar epithelial cells, and mouse lungs.

Koppe U, Högner K, Doehn JM, Müller HC, Witzenrath M, Gutbier B, Bauer S, Pribyl T, Hammerschmidt S, Lohmeyer J, Suttorp N, Herold S, Opitz B.

J Immunol. 2012 Jan 15;188(2):811-7. doi: 10.4049/jimmunol.1004143. Epub 2011 Dec 12.

17.

The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia.

Witzenrath M, Pache F, Lorenz D, Koppe U, Gutbier B, Tabeling C, Reppe K, Meixenberger K, Dorhoi A, Ma J, Holmes A, Trendelenburg G, Heimesaat MM, Bereswill S, van der Linden M, Tschopp J, Mitchell TJ, Suttorp N, Opitz B.

J Immunol. 2011 Jul 1;187(1):434-40. doi: 10.4049/jimmunol.1003143. Epub 2011 Jun 6.

18.

The Sphingosine-1 Phosphate receptor agonist FTY720 dose dependently affected endothelial integrity in vitro and aggravated ventilator-induced lung injury in mice.

Müller HC, Hocke AC, Hellwig K, Gutbier B, Peters H, Schönrock SM, Tschernig T, Schmiedl A, Hippenstiel S, N'Guessan PD, Rosseau S, Suttorp N, Witzenrath M.

Pulm Pharmacol Ther. 2011 Aug;24(4):377-85. doi: 10.1016/j.pupt.2011.01.017. Epub 2011 Mar 23.

PMID:
21419858
19.

Adrenomedullin attenuates ventilator-induced lung injury in mice.

Müller HC, Witzenrath M, Tschernig T, Gutbier B, Hippenstiel S, Santel A, Suttorp N, Rosseau S.

Thorax. 2010 Dec;65(12):1077-84. doi: 10.1136/thx.2010.135996. Epub 2010 Oct 22.

PMID:
20971983
20.

Simvastatin attenuates ventilator-induced lung injury in mice.

Müller HC, Hellwig K, Rosseau S, Tschernig T, Schmiedl A, Gutbier B, Schmeck B, Hippenstiel S, Peters H, Morawietz L, Suttorp N, Witzenrath M.

Crit Care. 2010;14(4):R143. doi: 10.1186/cc9209. Epub 2010 Jul 30.

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