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Items: 1 to 20 of 97

1.

Mitochondrial complex IV mutation increases reactive oxygen species production and reduces lifespan in aged mice.

Reichart G, Mayer J, Zehm C, Kirschstein T, Tokay T, Lange F, Baltrusch S, Tiedge M, Fuellen G, Ibrahim S, Köhling R.

Acta Physiol (Oxf). 2018 Oct 30:e13214. doi: 10.1111/apha.13214. [Epub ahead of print]

PMID:
30376218
2.

A workflow for the integrative transcriptomic description of molecular pathology and the suggestion of normalizing compounds, exemplified by Parkinson's disease.

Hamed M, Gladbach Y, Möller S, Fischer S, Ernst M, Struckmann S, Storch A, Fuellen G.

Sci Rep. 2018 May 21;8(1):7937. doi: 10.1038/s41598-018-25754-5.

3.

Comparative High-Resolution Transcriptome Sequencing of Lymphoma Cell Lines and de novo Lymphomas Reveals Cell-Line-Specific Pathway Dysregulation.

Taher L, Beck J, Liu W, Roolf C, Soller JT, Rütgen BC, Hammer SE, Chodisetti M, Sender S, Sterenczak KA, Fuellen G, Junghanss C, Brenig B, Nolte I, Schütz E, Murua Escobar H.

Sci Rep. 2018 Apr 19;8(1):6279. doi: 10.1038/s41598-018-23207-7.

4.

Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice.

Hirose M, Schilf P, Gupta Y, Zarse K, Künstner A, Fähnrich A, Busch H, Yin J, Wright MN, Ziegler A, Vallier M, Belheouane M, Baines JF, Tautz D, Johann K, Oelkrug R, Mittag J, Lehnert H, Othman A, Jöhren O, Schwaninger M, Prehn C, Adamski J, Shima K, Rupp J, Häsler R, Fuellen G, Köhling R, Ristow M, Ibrahim SM.

Sci Rep. 2018 Apr 12;8(1):5872. doi: 10.1038/s41598-018-24290-6.

5.

The informative error: A framework for the construction of individualized phenotypes.

Hertel J, Frenzel S, König J, Wittfeld K, Fuellen G, Holtfreter B, Pietzner M, Friedrich N, Nauck M, Völzke H, Kocher T, Grabe HJ.

Stat Methods Med Res. 2018 Jan 1:962280218759138. doi: 10.1177/0962280218759138. [Epub ahead of print]

PMID:
29468943
6.

Cellular vaccination of MLH1-/- mice - an immunotherapeutic proof of concept study.

Maletzki C, Gladbach YS, Hamed M, Fuellen G, Semmler ML, Stenzel J, Linnebacher M.

Oncoimmunology. 2017 Dec 14;7(3):e1408748. doi: 10.1080/2162402X.2017.1408748. eCollection 2018.

PMID:
29399413
7.

ADAM23 promotes neuronal differentiation of human neural progenitor cells.

Markus-Koch A, Schmitt O, Seemann S, Lukas J, Koczan D, Ernst M, Fuellen G, Wree A, Rolfs A, Luo J.

Cell Mol Biol Lett. 2017 Aug 18;22:16. doi: 10.1186/s11658-017-0045-1. eCollection 2017.

8.

The risks of biomarker-based epidemiology: Associations of circulating calcium levels with age, mortality, and frailty vary substantially across populations.

Cohen AA, Legault V, Fuellen G, Fülöp T, Fried LP, Ferrucci L.

Exp Gerontol. 2018 Jul 1;107:11-17. doi: 10.1016/j.exger.2017.07.011. Epub 2017 Jul 16. Review.

PMID:
28723411
9.

Mortality is associated with inflammation, anemia, specific diseases and treatments, and molecular markers.

Moeller M, Pink C, Endlich N, Endlich K, Grabe HJ, Völzke H, Dörr M, Nauck M, Lerch MM, Köhling R, Holtfreter B, Kocher T, Fuellen G.

PLoS One. 2017 Apr 19;12(4):e0175909. doi: 10.1371/journal.pone.0175909. eCollection 2017.

10.

FocusHeuristics - expression-data-driven network optimization and disease gene prediction.

Ernst M, Du Y, Warsow G, Hamed M, Endlich N, Endlich K, Murua Escobar H, Sklarz LM, Sender S, Junghanß C, Möller S, Fuellen G, Struckmann S.

Sci Rep. 2017 Feb 16;7:42638. doi: 10.1038/srep42638.

11.

Linking Hematopoietic Differentiation to Co-Expressed Sets of Pluripotency-Associated and Imprinted Genes and to Regulatory microRNA-Transcription Factor Motifs.

Hamed M, Trumm J, Spaniol C, Sethi R, Irhimeh MR, Fuellen G, Paulsen M, Helms V.

PLoS One. 2017 Jan 4;12(1):e0166852. doi: 10.1371/journal.pone.0166852. eCollection 2017.

12.

A novel assay to assess the effect of pharmaceutical compounds on the differentiation of podocytes.

Kindt F, Hammer E, Kemnitz S, Blumenthal A, Klemm P, Schlüter R, Quaggin SE, van den Brandt J, Fuellen G, Völker U, Endlich K, Endlich N.

Br J Pharmacol. 2017 Jan;174(2):163-176. doi: 10.1111/bph.13667. Epub 2016 Dec 20.

13.

Polymorphism in Murine mtATP8 Gene Correlates with Decreased Reactive Oxygen Species in Aging Hematopoietic Cells.

Roolf C, Kretzschmar C, Timmer K, Sekora A, Knübel G, Murua Escobar H, Fuellen G, Ibrahim SM, Tiedge M, Baltrusch S, Müller S, Köhling R, Junghanss C.

In Vivo. 2016 Nov 12;30(6):751-760.

PMID:
27815458
14.

Uncoupling protein 2 deficiency results in higher neutrophil counts and lower B-cell counts during aging in mice.

Kretzschmar C, Roolf C, Timmer K, Sekora A, Knübel G, Murua Escobar H, Jaster R, Müller S, Fuellen G, Köhling R, Junghanss C.

Exp Hematol. 2016 Nov;44(11):1085-1091.e2. doi: 10.1016/j.exphem.2016.08.003. Epub 2016 Aug 17.

PMID:
27544660
15.

Analysis of microRNA and Gene Expression Profiles in Multiple Sclerosis: Integrating Interaction Data to Uncover Regulatory Mechanisms.

Freiesleben S, Hecker M, Zettl UK, Fuellen G, Taher L.

Sci Rep. 2016 Oct 3;6:34512. doi: 10.1038/srep34512.

16.

Polymorphisms of the murine mitochondrial ND4, CYTB and COX3 genes impact hematopoiesis during aging.

Kretzschmar C, Roolf C, Timmer K, Sekora A, Knübel G, Murua Escobar H, Fuellen G, Ibrahim SM, Tiedge M, Baltrusch S, Jaster R, Köhling R, Junghanss C.

Oncotarget. 2016 Nov 15;7(46):74460-74472. doi: 10.18632/oncotarget.11952.

17.

Revealing complex function, process and pathway interactions with high-throughput expression and biological annotation data.

Singh NK, Ernst M, Liebscher V, Fuellen G, Taher L.

Mol Biosyst. 2016 Oct 20;12(10):3196-208. doi: 10.1039/c6mb00280c. Epub 2016 Aug 10.

PMID:
27507577
18.

Proteomic Analysis of Mouse Oocytes Identifies PRMT7 as a Reprogramming Factor that Replaces SOX2 in the Induction of Pluripotent Stem Cells.

Wang B, Pfeiffer MJ, Drexler HC, Fuellen G, Boiani M.

J Proteome Res. 2016 Aug 5;15(8):2407-21. doi: 10.1021/acs.jproteome.5b01083. Epub 2016 Jul 12.

19.

Ageing with elegans: a research proposal to map healthspan pathways.

Luyten W, Antal P, Braeckman BP, Bundy J, Cirulli F, Fang-Yen C, Fuellen G, Leroi A, Liu Q, Martorell P, Metspalu A, Perola M, Ristow M, Saul N, Schoofs L, Siems K, Temmerman L, Smets T, Wolk A, Rattan SI.

Biogerontology. 2016 Aug;17(4):771-82. doi: 10.1007/s10522-016-9644-x. Epub 2016 Apr 4.

PMID:
27040825
20.

Advanced Running Performance by Genetic Predisposition in Male Dummerstorf Marathon Mice (DUhTP) Reveals Higher Sterol Regulatory Element-Binding Protein (SREBP) Related mRNA Expression in the Liver and Higher Serum Levels of Progesterone.

Ohde D, Moeller M, Brenmoehl J, Walz C, Ponsuksili S, Schwerin M, Fuellen G, Hoeflich A.

PLoS One. 2016 Jan 22;11(1):e0146748. doi: 10.1371/journal.pone.0146748. eCollection 2016.

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