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Items: 1 to 20 of 28


Recombinant H5 hemagglutinin adjuvanted with nanoemulsion protects ferrets against pathogenic avian influenza virus challenge.

Wang SH, Smith D, Cao Z, Chen J, Acosta H, Chichester JA, Yusibov V, Streatfield SJ, Fattom A, Baker JR Jr.

Vaccine. 2019 Mar 14;37(12):1591-1600. doi: 10.1016/j.vaccine.2019.02.002. Epub 2019 Feb 19.


Purification and immunogenicity of hemagglutinin from highly pathogenic avian influenza virus H5N1 expressed in Nicotiana benthamiana.

Pua TL, Chan XY, Loh HS, Omar AR, Yusibov V, Musiychuk K, Hall AC, Coffin MV, Shoji Y, Chichester JA, Bi H, Streatfield SJ.

Hum Vaccin Immunother. 2017 Feb;13(2):306-313. doi: 10.1080/21645515.2017.1264783. Epub 2016 Dec 8.


Evaluation of inflammatory and immune responses in long-term cultured human precision-cut lung slices.

Temann A, Golovina T, Neuhaus V, Thompson C, Chichester JA, Braun A, Yusibov V.

Hum Vaccin Immunother. 2017 Feb;13(2):351-358. doi: 10.1080/21645515.2017.1264794.


Intranasal vaccination with a plant-derived H5 HA vaccine protects mice and ferrets against highly pathogenic avian influenza virus challenge.

Major D, Chichester JA, Pathirana RD, Guilfoyle K, Shoji Y, Guzman CA, Yusibov V, Cox RJ.

Hum Vaccin Immunother. 2015;11(5):1235-43. doi: 10.4161/21645515.2014.988554.


Advances and challenges in the development and production of effective plant-based influenza vaccines.

Yusibov V, Kushnir N, Streatfield SJ.

Expert Rev Vaccines. 2015 Apr;14(4):519-35. doi: 10.1586/14760584.2015.989988. Epub 2014 Dec 9. Review.


Immunogenicity of H1N1 influenza virus-like particles produced in Nicotiana benthamiana.

Shoji Y, Prokhnevsky A, Leffet B, Vetter N, Tottey S, Satinover S, Musiychuk K, Shamloul M, Norikane J, Jones RM, Chichester JA, Green BJ, Streatfield SJ, Yusibov V.

Hum Vaccin Immunother. 2015;11(1):118-23. doi: 10.4161/hv.34365. Epub 2014 Nov 1.


Stabilization of HAC1 influenza vaccine by spray drying: formulation development and process scale-up.

Zhu C, Shoji Y, McCray S, Burke M, Hartman CE, Chichester JA, Breit J, Yusibov V, Chen D, Lal M.

Pharm Res. 2014 Nov;31(11):3006-18. doi: 10.1007/s11095-014-1394-3. Epub 2014 May 24.


Optimization and utilization of Agrobacterium-mediated transient protein production in Nicotiana.

Shamloul M, Trusa J, Mett V, Yusibov V.

J Vis Exp. 2014 Apr 19;(86). doi: 10.3791/51204.


A new adjuvanted nanoparticle-based H1N1 influenza vaccine induced antigen-specific local mucosal and systemic immune responses after administration into the lung.

Neuhaus V, Chichester JA, Ebensen T, Schwarz K, Hartman CE, Shoji Y, Guzmán CA, Yusibov V, Sewald K, Braun A.

Vaccine. 2014 May 30;32(26):3216-22. doi: 10.1016/j.vaccine.2014.04.011. Epub 2014 Apr 13.


Safety and immunogenicity of a plant-produced recombinant monomer hemagglutinin-based influenza vaccine derived from influenza A (H1N1)pdm09 virus: a Phase 1 dose-escalation study in healthy adults.

Cummings JF, Guerrero ML, Moon JE, Waterman P, Nielsen RK, Jefferson S, Gross FL, Hancock K, Katz JM, Yusibov V; Fraunhofer USA Center for Molecular Biotechnology Study Group.

Vaccine. 2014 Apr 17;32(19):2251-9. doi: 10.1016/j.vaccine.2013.10.017. Epub 2013 Oct 12.


Functional testing of an inhalable nanoparticle based influenza vaccine using a human precision cut lung slice technique.

Neuhaus V, Schwarz K, Klee A, Seehase S, Förster C, Pfennig O, Jonigk D, Fieguth HG, Koch W, Warnecke G, Yusibov V, Sewald K, Braun A.

PLoS One. 2013 Aug 13;8(8):e71728. doi: 10.1371/journal.pone.0071728. eCollection 2013.


A plant-produced H1N1 trimeric hemagglutinin protects mice from a lethal influenza virus challenge.

Shoji Y, Jones RM, Mett V, Chichester JA, Musiychuk K, Sun X, Tumpey TM, Green BJ, Shamloul M, Norikane J, Bi H, Hartman CE, Bottone C, Stewart M, Streatfield SJ, Yusibov V.

Hum Vaccin Immunother. 2013 Mar;9(3):553-60. Epub 2013 Jan 7.


The human potential of a recombinant pandemic influenza vaccine produced in tobacco plants.

Jul-Larsen Å, Madhun AS, Brokstad KA, Montomoli E, Yusibov V, Cox RJ.

Hum Vaccin Immunother. 2012 May;8(5):653-61. doi: 10.4161/hv.19503. Epub 2012 May 1.


Comparative characterization of the glycosylation profiles of an influenza hemagglutinin produced in plant and insect hosts.

Zhang S, Sherwood RW, Yang Y, Fish T, Chen W, McCardle JA, Jones RM, Yusibov V, May ER, Rose JK, Thannhauser TW.

Proteomics. 2012 Apr;12(8):1269-88. doi: 10.1002/pmic.201100474.


Formulation development of a plant-derived H1N1 influenza vaccine containing purified recombinant hemagglutinin antigen.

Iyer V, Liyanage MR, Shoji Y, Chichester JA, Jones RM, Yusibov V, Joshi SB, Middaugh CR.

Hum Vaccin Immunother. 2012 Apr;8(4):453-64. doi: 10.4161/hv.19106. Epub 2012 Feb 28.


A plant-based system for rapid production of influenza vaccine antigens.

Shoji Y, Farrance CE, Bautista J, Bi H, Musiychuk K, Horsey A, Park H, Jaje J, Green BJ, Shamloul M, Sharma S, Chichester JA, Mett V, Yusibov V.

Influenza Other Respir Viruses. 2012 May;6(3):204-10. doi: 10.1111/j.1750-2659.2011.00295.x. Epub 2011 Oct 4.


An influenza N1 neuraminidase-specific monoclonal antibody with broad neuraminidase inhibition activity against H5N1 HPAI viruses.

Shoji Y, Chichester JA, Palmer GA, Farrance CE, Stevens R, Stewart M, Goldschmidt L, Deyde V, Gubareva L, Klimov A, Mett V, Yusibov V.

Hum Vaccin. 2011 Jan-Feb;7 Suppl:199-204.


Co-expression of multiple target proteins in plants from a tobacco mosaic virus vector using a combination of homologous and heterologous subgenomic promoters.

Roy G, Weisburg S, Foy K, Rabindran S, Mett V, Yusibov V.

Arch Virol. 2011 Nov;156(11):2057-61. doi: 10.1007/s00705-011-1069-x. Epub 2011 Jul 21.


Intranasal c-di-GMP-adjuvanted plant-derived H5 influenza vaccine induces multifunctional Th1 CD4+ cells and strong mucosal and systemic antibody responses in mice.

Madhun AS, Haaheim LR, Nøstbakken JK, Ebensen T, Chichester J, Yusibov V, Guzman CA, Cox RJ.

Vaccine. 2011 Jul 12;29(31):4973-82. doi: 10.1016/j.vaccine.2011.04.094. Epub 2011 May 18.


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