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Cell. 2007 Oct 5;131(1):13-4.

Retrovirus silencing by an epigenetic TRIM.

Author information

1
Developmental and Stem Cell Biology Program, SickKids Hospital, Toronto, Ontario, Canada. jellis@sickkids.ca

Abstract

Embryonic cells silence transcription by retroviruses, but how do they recognize virus DNA? In this issue, Wolf and Goff (2007) report that a TRIM28 corepressor complex binds to the retrovirus primer binding site. Epigenetic silencing of retrovirus transcription is accomplished by "writing" a dimethyl mark on lysine 9 of histone H3 that is read by the heterochromatin protein HP1gamma.

PMID:
17923079
DOI:
10.1016/j.cell.2007.09.029
[Indexed for MEDLINE]
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