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Items: 1 to 20 of 108


Real-world data on discordance between estrogen, progesterone, and HER2 receptor expression on diagnostic tumor biopsy versus tumor resection material.

Berghuis AMS, van Deurzen CHM, Koffijberg H, Terstappen LWMM, Sleijfer S, IJzerman MJ.

Breast Cancer Res Treat. 2019 Feb 13. doi: 10.1007/s10549-019-05141-y. [Epub ahead of print]


EpCAMhigh and EpCAMlow circulating tumor cells in metastatic prostate and breast cancer patients.

de Wit S, Manicone M, Rossi E, Lampignano R, Yang L, Zill B, Rengel-Puertas A, Ouhlen M, Crespo M, Berghuis AMS, Andree KC, Vidotto R, Trapp EK, Tzschaschel M, Colomba E, Fowler G, Flohr P, Rescigno P, Fontes MS, Zamarchi R, Fehm T, Neubauer H, Rack B, Alunni-Fabbroni M, Farace F, De Bono J, IJzerman MJ, Terstappen LWMM.

Oncotarget. 2018 Nov 2;9(86):35705-35716. doi: 10.18632/oncotarget.26298. eCollection 2018 Nov 2.


Cost-effectiveness of procalcitonin testing to guide antibiotic treatment duration in critically ill patients: results from a randomised controlled multicentre trial in the Netherlands.

Kip MMA, van Oers JA, Shajiei A, Beishuizen A, Berghuis AMS, Girbes AR, de Jong E, de Lange DW, Nijsten MWN, IJzerman MJ, Koffijberg H, Kusters R.

Crit Care. 2018 Nov 13;22(1):293. doi: 10.1186/s13054-018-2234-3.


TRPV4 and KRAS and FGFR1 gain-of-function mutations drive giant cell lesions of the jaw.

Gomes CC, Gayden T, Bajic A, Harraz OF, Pratt J, Nikbakht H, Bareke E, Diniz MG, Castro WH, St-Onge P, Sinnett D, Han H, Rivera B, Mikael LG, De Jay N, Kleinman CL, Valera ET, Bassenden AV, Berghuis AM, Majewski J, Nelson MT, Gomez RS, Jabado N.

Nat Commun. 2018 Nov 1;9(1):4572. doi: 10.1038/s41467-018-06690-4.


A potential gain-of-function variant of SLC9A6 leads to endosomal alkalinization and neuronal atrophy associated with Christianson Syndrome.

Ilie A, Gao AYL, Boucher A, Park J, Berghuis AM, Hoffer MJV, Hilhorst-Hofstee Y, McKinney RA, Orlowski J.

Neurobiol Dis. 2019 Jan;121:187-204. doi: 10.1016/j.nbd.2018.10.002. Epub 2018 Oct 5.


How to Agree on a CTC: Evaluating the Consensus in Circulating Tumor Cell Scoring.

Zeune LL, de Wit S, Berghuis AMS, IJzerman MJ, Terstappen LWMM, Brune C.

Cytometry A. 2018 Dec;93(12):1202-1206. doi: 10.1002/cyto.a.23576. Epub 2018 Sep 24.


Look and Outlook on Enzyme-Mediated Macrolide Resistance.

Golkar T, Zieliński M, Berghuis AM.

Front Microbiol. 2018 Aug 20;9:1942. doi: 10.3389/fmicb.2018.01942. eCollection 2018. Review.


Health economic impact of liquid biopsies in cancer management.

IJzerman MJ, Berghuis AMS, de Bono JS, Terstappen LWMM.

Expert Rev Pharmacoecon Outcomes Res. 2018 Dec;18(6):593-599. doi: 10.1080/14737167.2018.1505505. Epub 2018 Aug 7.


Unraveling the Prenylation-Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors.

Lacbay CM, Waller DD, Park J, Gómez Palou M, Vincent F, Huang XF, Ta V, Berghuis AM, Sebag M, Tsantrizos YS.

J Med Chem. 2018 Aug 9;61(15):6904-6917. doi: 10.1021/acs.jmedchem.8b00886. Epub 2018 Jul 25.


Evidence on the cost of breast cancer drugs is required for rational decision making.

Berghuis AMS, Koffijberg H, Terstappen LWMM, Sleijfer S, IJzerman MJ.

Ecancermedicalscience. 2018 Apr 16;12:825. doi: 10.3332/ecancer.2018.825. eCollection 2018.


Plasticity of Aminoglycoside Binding to Antibiotic Kinase APH(2″)-Ia.

Caldwell SJ, Berghuis AM.

Antimicrob Agents Chemother. 2018 Jun 26;62(7). pii: e00202-18. doi: 10.1128/AAC.00202-18. Print 2018 Jul.


Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase.

Park J, Rodionov D, De Schutter JW, Lin YS, Tsantrizos YS, Berghuis AM.

PLoS One. 2017 Oct 16;12(10):e0186447. doi: 10.1371/journal.pone.0186447. eCollection 2017.


Biophysics in Canada.

Baenziger J, Kay L, Berghuis A, Tieleman P.

Biochim Biophys Acta Proteins Proteom. 2017 Nov;1865(11 Pt B):1479-1482. doi: 10.1016/j.bbapap.2017.10.002. No abstract available.


Effect of solvent and protein dynamics in ligand recognition and inhibition of aminoglycoside adenyltransferase 2″-Ia.

Bacot-Davis VR, Bassenden AV, Sprules T, Berghuis AM.

Protein Sci. 2017 Sep;26(9):1852-1863. doi: 10.1002/pro.3224. Epub 2017 Jul 21.


Functionally Null RAD51D Missense Mutation Associates Strongly with Ovarian Carcinoma.

Rivera B, Di Iorio M, Frankum J, Nadaf J, Fahiminiya S, Arcand SL, Burk DL, Grapton D, Tomiak E, Hastings V, Hamel N, Wagener R, Aleynikova O, Giroux S, Hamdan FF, Dionne-Laporte A, Zogopoulos G, Rousseau F, Berghuis AM, Provencher D, Rouleau GA, Michaud JL, Mes-Masson AM, Majewski J, Bens S, Siebert R, Narod SA, Akbari MR, Lord CJ, Tonin PN, Orthwein A, Foulkes WD.

Cancer Res. 2017 Aug 15;77(16):4517-4529. doi: 10.1158/0008-5472.CAN-17-0190. Epub 2017 Jun 23.


Structural Basis for Kinase-Mediated Macrolide Antibiotic Resistance.

Fong DH, Burk DL, Blanchet J, Yan AY, Berghuis AM.

Structure. 2017 May 2;25(5):750-761.e5. doi: 10.1016/j.str.2017.03.007. Epub 2017 Apr 13.


Detecting Blood-Based Biomarkers in Metastatic Breast Cancer: A Systematic Review of Their Current Status and Clinical Utility.

Berghuis AMS, Koffijberg H, Prakash J, Terstappen LW, IJzerman MJ.

Int J Mol Sci. 2017 Feb 9;18(2). pii: E363. doi: 10.3390/ijms18020363. Review.


Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase.

Park J, Leung CY, Matralis AN, Lacbay CM, Tsakos M, Fernandez De Troconiz G, Berghuis AM, Tsantrizos YS.

J Med Chem. 2017 Mar 9;60(5):2119-2134. doi: 10.1021/acs.jmedchem.6b01888. Epub 2017 Feb 28.


Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product.

Park J, Zielinski M, Magder A, Tsantrizos YS, Berghuis AM.

Nat Commun. 2017 Jan 18;8:14132. doi: 10.1038/ncomms14132.


The role of conformational flexibility in Baeyer-Villiger monooxygenase catalysis and structure.

Yachnin BJ, Lau PCK, Berghuis AM.

Biochim Biophys Acta. 2016 Dec;1864(12):1641-1648. doi: 10.1016/j.bbapap.2016.08.015. Epub 2016 Aug 26.


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