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Items: 1 to 20 of 22

1.

A mouse model for monitoring islet cell genesis and developing therapies for diabetes.

Shimajiri Y, Kosaka Y, Scheel DW, Lynn FC, Kishimoto N, Wang J, Zhao S, German MS.

Dis Model Mech. 2011 Mar;4(2):268-76. doi: 10.1242/dmm.002998. Epub 2010 Dec 6.

2.

Serotonin regulates pancreatic beta cell mass during pregnancy.

Kim H, Toyofuku Y, Lynn FC, Chak E, Uchida T, Mizukami H, Fujitani Y, Kawamori R, Miyatsuka T, Kosaka Y, Yang K, Honig G, van der Hart M, Kishimoto N, Wang J, Yagihashi S, Tecott LH, Watada H, German MS.

Nat Med. 2010 Jul;16(7):804-8. doi: 10.1038/nm.2173. Epub 2010 Jun 27.

3.

Rfx6 directs islet formation and insulin production in mice and humans.

Smith SB, Qu HQ, Taleb N, Kishimoto NY, Scheel DW, Lu Y, Patch AM, Grabs R, Wang J, Lynn FC, Miyatsuka T, Mitchell J, Seerke R, Désir J, Vanden Eijnden S, Abramowicz M, Kacet N, Weill J, Renard ME, Gentile M, Hansen I, Dewar K, Hattersley AT, Wang R, Wilson ME, Johnson JD, Polychronakos C, German MS.

Nature. 2010 Feb 11;463(7282):775-80. doi: 10.1038/nature08748.

4.

Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors.

Wang YC, Gallego-Arteche E, Iezza G, Yuan X, Matli MR, Choo SP, Zuraek MB, Gogia R, Lynn FC, German MS, Bergsland EK, Donner DB, Warren RS, Nakakura EK.

Endocr Relat Cancer. 2009 Mar;16(1):267-79. doi: 10.1677/ERC-08-0127. Epub 2008 Nov 5.

PMID:
18987169
5.

Novel glucagon receptor antagonists with improved selectivity over the glucose-dependent insulinotropic polypeptide receptor.

Kodra JT, Jørgensen AS, Andersen B, Behrens C, Brand CL, Christensen IT, Guldbrandt M, Jeppesen CB, Knudsen LB, Madsen P, Nishimura E, Sams C, Sidelmann UG, Pedersen RA, Lynn FC, Lau J.

J Med Chem. 2008 Sep 11;51(17):5387-96. doi: 10.1021/jm7015599. Epub 2008 Aug 16.

PMID:
18707090
6.

Mouse let-7 miRNA populations exhibit RNA editing that is constrained in the 5'-seed/ cleavage/anchor regions and stabilize predicted mmu-let-7a:mRNA duplexes.

Reid JG, Nagaraja AK, Lynn FC, Drabek RB, Muzny DM, Shaw CA, Weiss MK, Naghavi AO, Khan M, Zhu H, Tennakoon J, Gunaratne GH, Corry DB, Miller J, McManus MT, German MS, Gibbs RA, Matzuk MM, Gunaratne PH.

Genome Res. 2008 Oct;18(10):1571-81. doi: 10.1101/gr.078246.108. Epub 2008 Jul 9.

7.

Identification of the bHLH factor Math6 as a novel component of the embryonic pancreas transcriptional network.

Lynn FC, Sanchez L, Gomis R, German MS, Gasa R.

PLoS One. 2008 Jun 18;3(6):e2430. doi: 10.1371/journal.pone.0002430.

8.

Induction of pancreatic islet cell differentiation by the neurogenin-neuroD cascade.

Gasa R, Mrejen C, Lynn FC, Skewes-Cox P, Sanchez L, Yang KY, Lin CH, Gomis R, German MS.

Differentiation. 2008 Apr;76(4):381-91. Epub 2007 Oct 9.

PMID:
17924961
9.

MicroRNA expression is required for pancreatic islet cell genesis in the mouse.

Lynn FC, Skewes-Cox P, Kosaka Y, McManus MT, Harfe BD, German MS.

Diabetes. 2007 Dec;56(12):2938-45. Epub 2007 Sep 5.

10.

Reversal of islet GIP receptor down-regulation and resistance to GIP by reducing hyperglycemia in the Zucker rat.

Piteau S, Olver A, Kim SJ, Winter K, Pospisilik JA, Lynn F, Manhart S, Demuth HU, Speck M, Pederson RA, McIntosh CH.

Biochem Biophys Res Commun. 2007 Nov 3;362(4):1007-12. Epub 2007 Aug 29.

PMID:
17803965
11.

Sox9 coordinates a transcriptional network in pancreatic progenitor cells.

Lynn FC, Smith SB, Wilson ME, Yang KY, Nekrep N, German MS.

Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10500-5. Epub 2007 Jun 11.

12.

The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas.

Wilson ME, Yang KY, Kalousova A, Lau J, Kosaka Y, Lynn FC, Wang J, Mrejen C, Episkopou V, Clevers HC, German MS.

Diabetes. 2005 Dec;54(12):3402-9.

13.

Structure-activity relationships of glucose-dependent insulinotropic polypeptide (GIP).

Hinke SA, Gelling R, Manhart S, Lynn F, Pederson RA, Kühn-Wache K, Rosche F, Demuth HU, Coy D, McIntosh CH.

Biol Chem. 2003 Mar;384(3):403-7.

PMID:
12715891
14.

Glucose-dependent insulinotropic polypeptide (GIP): development of DP IV-resistant analogues with therapeutic potential.

Hinke SA, Lynn F, Ehses J, Pamir N, Manhart S, Kühn-Wache K, Rosche F, Demuth HU, Pederson RA, McIntosh CH.

Adv Exp Med Biol. 2003;524:293-301. No abstract available.

PMID:
12675251
15.

Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats.

Pospisilik JA, Martin J, Doty T, Ehses JA, Pamir N, Lynn FC, Piteau S, Demuth HU, McIntosh CH, Pederson RA.

Diabetes. 2003 Mar;52(3):741-50.

16.

Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis.

Pamir N, Lynn FC, Buchan AM, Ehses J, Hinke SA, Pospisilik JA, Miyawaki K, Yamada Y, Seino Y, McIntosh CH, Pederson RA.

Am J Physiol Endocrinol Metab. 2003 May;284(5):E931-9. Epub 2003 Jan 21.

17.

A novel pathway for regulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta cells.

Lynn FC, Thompson SA, Pospisilik JA, Ehses JA, Hinke SA, Pamir N, McIntosh CH, Pederson RA.

FASEB J. 2003 Jan;17(1):91-3. Epub 2002 Nov 15.

PMID:
12475913
18.

Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats.

Lynn FC, Pamir N, Ng EH, McIntosh CH, Kieffer TJ, Pederson RA.

Diabetes. 2001 May;50(5):1004-11.

19.
20.

Improved glucose tolerance in rats treated with the dipeptidyl peptidase IV (CD26) inhibitor Ile-thiazolidide.

Pauly RP, Demuth HU, Rosche F, Schmidt J, White HA, Lynn F, McIntosh CH, Pederson RA.

Metabolism. 1999 Mar;48(3):385-9.

PMID:
10094118

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