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Items: 1 to 20 of 37


UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors.

Jachimowicz RD, Beleggia F, Isensee J, Velpula BB, Goergens J, Bustos MA, Doll MA, Shenoy A, Checa-Rodriguez C, Wiederstein JL, Baranes-Bachar K, Bartenhagen C, Hertwig F, Teper N, Nishi T, Schmitt A, Distelmaier F, Lüdecke HJ, Albrecht B, Krüger M, Schumacher B, Geiger T, Hoon DSB, Huertas P, Fischer M, Hucho T, Peifer M, Ziv Y, Reinhardt HC, Wieczorek D, Shiloh Y.

Cell. 2018 Dec 21. pii: S0092-8674(18)31516-2. doi: 10.1016/j.cell.2018.11.024. [Epub ahead of print]


The Cdkn1aSUPER Mouse as a Tool to Study p53-Mediated Tumor Suppression.

Torgovnick A, Heger JM, Liaki V, Isensee J, Schmitt A, Knittel G, Riabinska A, Beleggia F, Laurien L, Leeser U, Jüngst C, Siedek F, Vogel W, Klümper N, Nolte H, Wittersheim M, Tharun L, Castiglione R, Krüger M, Schauss A, Perner S, Pasparakis M, Büttner R, Persigehl T, Hucho T, Herter-Sprie GS, Schumacher B, Reinhardt HC.

Cell Rep. 2018 Oct 23;25(4):1027-1039.e6. doi: 10.1016/j.celrep.2018.09.079.


The beta-adrenergic receptor agonist, terbutaline, reduces UVB-induced mechanical sensitization in humans.

Loeser J, Blunk JA, Ruschulte H, Knitsch J, Karst M, Hucho T.

Eur J Pain. 2019 Jan;23(1):72-80. doi: 10.1002/ejp.1286. Epub 2018 Aug 6.


Evaluation of small intestinal damage in a rat model of 6 Minutes cardiac arrest.

Schroeder DC, Maul AC, Mahabir E, Koxholt I, Yan X, Padosch SA, Herff H, Bultmann-Mellin I, Sterner-Kock A, Annecke T, Hucho T, Böttiger BW, Guschlbauer M.

BMC Anesthesiol. 2018 Jun 5;18(1):61. doi: 10.1186/s12871-018-0530-8.


A Hierarchical, Data-Driven Approach to Modeling Single-Cell Populations Predicts Latent Causes of Cell-To-Cell Variability.

Loos C, Moeller K, Fröhlich F, Hucho T, Hasenauer J.

Cell Syst. 2018 May 23;6(5):593-603.e13. doi: 10.1016/j.cels.2018.04.008. Epub 2018 May 2.


PKA-RII subunit phosphorylation precedes activation by cAMP and regulates activity termination.

Isensee J, Kaufholz M, Knape MJ, Hasenauer J, Hammerich H, Gonczarowska-Jorge H, Zahedi RP, Schwede F, Herberg FW, Hucho T.

J Cell Biol. 2018 Jun 4;217(6):2167-2184. doi: 10.1083/jcb.201708053. Epub 2018 Apr 3.


Characterization of tumor-associated T-lymphocyte subsets and immune checkpoint molecules in head and neck squamous cell carcinoma.

Lechner A, Schlößer H, Rothschild SI, Thelen M, Reuter S, Zentis P, Shimabukuro-Vornhagen A, Theurich S, Wennhold K, Garcia-Marquez M, Tharun L, Quaas A, Schauss A, Isensee J, Hucho T, Huebbers C, von Bergwelt-Baildon M, Beutner D.

Oncotarget. 2017 Jul 4;8(27):44418-44433. doi: 10.18632/oncotarget.17901.


Crosstalk from cAMP to ERK1/2 emerges during postnatal maturation of nociceptive neurons and is maintained during aging.

Isensee J, Schild C, Schwede F, Hucho T.

J Cell Sci. 2017 Jul 1;130(13):2134-2146. doi: 10.1242/jcs.197327. Epub 2017 May 17.


Ankyrin-rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1-function in nociceptive neurons.

Peter J, Kasper C, Kaufholz M, Buschow R, Isensee J, Hucho T, Herberg FW, Schwede F, Stein C, Jordt SE, Brackmann M, Spahn V.

Eur J Pain. 2017 Jul;21(6):1072-1086. doi: 10.1002/ejp.1008. Epub 2017 Feb 9.


Synergistic regulation of serotonin and opioid signaling contributes to pain insensitivity in Nav1.7 knockout mice.

Isensee J, Krahé L, Moeller K, Pereira V, Sexton JE, Sun X, Emery E, Wood JN, Hucho T.

Sci Signal. 2017 Jan 10;10(461). pii: eaah4874. doi: 10.1126/scisignal.aah4874.


The bromodomain protein BRD4 regulates splicing during heat shock.

Hussong M, Kaehler C, Kerick M, Grimm C, Franz A, Timmermann B, Welzel F, Isensee J, Hucho T, Krobitsch S, Schweiger MR.

Nucleic Acids Res. 2017 Jan 9;45(1):382-394. doi: 10.1093/nar/gkw729. Epub 2016 Aug 17.


Subgroup-elimination transcriptomics identifies signaling proteins that define subclasses of TRPV1-positive neurons and a novel paracrine circuit.

Isensee J, Wenzel C, Buschow R, Weissmann R, Kuss AW, Hucho T.

PLoS One. 2014 Dec 31;9(12):e115731. doi: 10.1371/journal.pone.0115731. eCollection 2014.


[1 + 1 = 0. Reprogramming of nociceptors].

Hucho T.

Schmerz. 2014 Dec;28(6):628-30. doi: 10.1007/s00482-014-1465-8. German. No abstract available.


ODE constrained mixture modelling: a method for unraveling subpopulation structures and dynamics.

Hasenauer J, Hasenauer C, Hucho T, Theis FJ.

PLoS Comput Biol. 2014 Jul 3;10(7):e1003686. doi: 10.1371/journal.pcbi.1003686. eCollection 2014 Jul.


5-Fluorouracil affects assembly of stress granules based on RNA incorporation.

Kaehler C, Isensee J, Hucho T, Lehrach H, Krobitsch S.

Nucleic Acids Res. 2014 Jun;42(10):6436-47. doi: 10.1093/nar/gku264. Epub 2014 Apr 11.


Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons.

Isensee J, Diskar M, Waldherr S, Buschow R, Hasenauer J, Prinz A, Allgöwer F, Herberg FW, Hucho T.

J Cell Sci. 2014 Jan 1;127(Pt 1):216-29. doi: 10.1242/jcs.136580. Epub 2013 Nov 4.


Wound-healing growth factor, basic FGF, induces Erk1/2-dependent mechanical hyperalgesia.

Andres C, Hasenauer J, Ahn HS, Joseph EK, Isensee J, Theis FJ, Allgöwer F, Levine JD, Dib-Hajj SD, Waxman SG, Hucho T.

Pain. 2013 Oct;154(10):2216-26. doi: 10.1016/j.pain.2013.07.005. Epub 2013 Jul 16.


Ataxin-2-like is a regulator of stress granules and processing bodies.

Kaehler C, Isensee J, Nonhoff U, Terrey M, Hucho T, Lehrach H, Krobitsch S.

PLoS One. 2012;7(11):e50134. doi: 10.1371/journal.pone.0050134. Epub 2012 Nov 27.


Ca++/CaMKII switches nociceptor-sensitizing stimuli into desensitizing stimuli.

Hucho T, Suckow V, Joseph EK, Kuhn J, Schmoranzer J, Dina OA, Chen X, Karst M, Bernateck M, Levine JD, Ropers HH.

J Neurochem. 2012 Nov;123(4):589-601. doi: 10.1111/j.1471-4159.2012.07920.x. Epub 2012 Sep 28.


Threshold-free population analysis identifies larger DRG neurons to respond stronger to NGF stimulation.

Andres C, Hasenauer J, Allgower F, Hucho T.

PLoS One. 2012;7(3):e34257. doi: 10.1371/journal.pone.0034257. Epub 2012 Mar 27.

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