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Efficacy and safety of fidaxomicin for the treatment of Clostridioides (Clostridium) difficile infection in a randomized, double-blind, comparative Phase III study in Japan.

Mikamo H, Tateda K, Yanagihara K, Kusachi S, Takesue Y, Miki T, Oizumi Y, Gamo K, Hashimoto A, Toyoshima J, Kato K.

J Infect Chemother. 2018 Sep;24(9):744-752. doi: 10.1016/j.jiac.2018.05.010. Epub 2018 Jun 19.


Pooled analysis of the phase 3 REVIVE trials: randomised, double-blind studies to evaluate the safety and efficacy of iclaprim versus vancomycin for treatment of acute bacterial skin and skin-structure infections.

Huang DB, Corey GR, Holland TL, Lodise T, O'Riordan W, Wilcox MH, File TM Jr, Dryden M, Balser B, Desplats E, Torres A.

Int J Antimicrob Agents. 2018 Aug;52(2):233-240. doi: 10.1016/j.ijantimicag.2018.05.012. Epub 2018 May 19.


Delafloxacin: an improved fluoroquinolone developed through advanced molecular engineering.

Bassetti M, Righi E, Pecori D, Tillotson G.

Future Microbiol. 2018 Aug;13:1081-1094. doi: 10.2217/fmb-2018-0067. Epub 2018 May 16.


Streptococcus agalactiae carriage among pregnant women living in Rio de Janeiro, Brazil, over a period of eight years.

Botelho ACN, Oliveira JG, Damasco AP, Santos KTB, Ferreira AFM, Rocha GT, Marinho PS, Bornia RBG, Pinto TCA, Américo MA, Fracalanzza SEL, Teixeira LM.

PLoS One. 2018 May 11;13(5):e0196925. doi: 10.1371/journal.pone.0196925. eCollection 2018.


Questions Frequently Asked of Healthcare Professionals: A 2-Year Data Survey Conducted at a Medical Center.

Hou CL, Lu YH, Chien SC, Chen HH, Chen CY.

Biomed Res Int. 2018 Feb 14;2018:4895850. doi: 10.1155/2018/4895850. eCollection 2018.


Efficacy and safety of fosfomycin plus imipenem versus vancomycin for complicated bacteraemia and endocarditis due to methicillin-resistant Staphylococcus aureus: a randomized clinical trial.

Pericàs JM, Moreno A, Almela M, García-de-la-Mària C, Marco F, Muñoz P, Peña C, de Alarcón A, Del Río A, Eworo A, Cruceta A, Paré JC, Mestres CA, Miró JM; FOSIMI Investigators.

Clin Microbiol Infect. 2018 Jun;24(6):673-676. doi: 10.1016/j.cmi.2018.01.010. Epub 2018 Feb 3. No abstract available.


Randomized clinical trial to evaluate the effect of fecal microbiota transplant for initial Clostridium difficile infection in intestinal microbiome.

Camacho-Ortiz A, Gutiérrez-Delgado EM, Garcia-Mazcorro JF, Mendoza-Olazarán S, Martínez-Meléndez A, Palau-Davila L, Baines SD, Maldonado-Garza H, Garza-González E.

PLoS One. 2017 Dec 20;12(12):e0189768. doi: 10.1371/journal.pone.0189768. eCollection 2017.


Factors Influencing Norvancomycin Concentration in Plasma and Cerebrospinal Fluid in Patients After Craniotomy and Dosing Guideline: A Population Approach.

Li X, Wu Y, Sun S, Wang Q, Zhao Z.

Clin Ther. 2018 Jan;40(1):74-82.e1. doi: 10.1016/j.clinthera.2017.11.005. Epub 2017 Dec 8.


A prospective multicentre randomized placebo-controlled superiority trial in patients with suspected bacterial endophthalmitis after cataract surgery on the adjuvant use of intravitreal dexamethasone to intravitreal antibiotics.

Manning S, Ugahary LC, Lindstedt EW, Wubbels RJ, van Dissel JT, Jansen JTG, Gan I, van Goor AT, Bennebroek CA, van der Werf DJ, Ossewaarde-van Norel A, Mayland Nielsen CC, Tilanus M, van den Biesen PR, Schellekens PA, La Heij E, Faridpooya K, van Overdam K, Veckeneer M, van Meurs JC.

Acta Ophthalmol. 2018 Jun;96(4):348-355. doi: 10.1111/aos.13610. Epub 2017 Dec 7.


The effect of bezlotoxumab for prevention of recurrent Clostridium difficile infection (CDI) in Japanese patients.

Mikamo H, Aoyama N, Sawata M, Fujimoto G, Dorr MB, Yoshinari T.

J Infect Chemother. 2018 Feb;24(2):123-129. doi: 10.1016/j.jiac.2017.10.005. Epub 2017 Oct 31.


Efficacy and safety of delafloxacin compared with vancomycin plus aztreonam for acute bacterial skin and skin structure infections: a Phase 3, double-blind, randomized study.

Pullman J, Gardovskis J, Farley B, Sun E, Quintas M, Lawrence L, Ling R, Cammarata S; PROCEED Study Group.

J Antimicrob Chemother. 2017 Dec 1;72(12):3471-3480. doi: 10.1093/jac/dkx329.


Levofloxacin Prophylaxis During Induction Therapy for Pediatric Acute Lymphoblastic Leukemia.

Wolf J, Tang L, Flynn PM, Pui CH, Gaur AH, Sun Y, Inaba H, Stewart T, Hayden RT, Hakim H, Jeha S.

Clin Infect Dis. 2017 Nov 13;65(11):1790-1798. doi: 10.1093/cid/cix644.


Surotomycin versus vancomycin in adults with Clostridium difficile infection: primary clinical outcomes from the second pivotal, randomized, double-blind, Phase 3 trial.

Daley P, Louie T, Lutz JE, Khanna S, Stoutenburgh U, Jin M, Adedoyin A, Chesnel L, Guris D, Larson KB, Murata Y.

J Antimicrob Chemother. 2017 Dec 1;72(12):3462-3470. doi: 10.1093/jac/dkx299.


Enteric microbiome profiles during a randomized Phase 2 clinical trial of surotomycin versus vancomycin for the treatment of Clostridium difficile infection.

Cannon K, Byrne B, Happe J, Wu K, Ward L, Chesnel L, Louie T.

J Antimicrob Chemother. 2017 Dec 1;72(12):3453-3461. doi: 10.1093/jac/dkx318.


Polyethylene glycol intestinal lavage in addition to usual antibiotic treatment for severe Clostridium difficile colitis: a randomised controlled pilot study.

McCreery G, Jones PM, Kidane B, DeMelo V, Mele T; ERASE C. difficile (Early Rescue from Acute SEvere Clostridium difficile) Trials Group.

BMJ Open. 2017 Jul 31;7(7):e016803. doi: 10.1136/bmjopen-2017-016803.


Dissemination and Molecular Characterization of Staphylococcus aureus at a Tertiary Referral Hospital in Xiamen City, China.

Yu Y, Yao Y, Weng Q, Li J, Huang J, Liao Y, Zhu F, Zhao Q, Shen X, Niu J.

Biomed Res Int. 2017;2017:1367179. doi: 10.1155/2017/1367179. Epub 2017 Jul 5.


A Phase II Randomized, Double-blind, Multicenter Study to Evaluate Efficacy and Safety of Intravenous Iclaprim Versus Vancomycin for the Treatment of Nosocomial Pneumonia Suspected or Confirmed to be Due to Gram-positive Pathogens.

Huang DB, File TM Jr, Torres A, Shorr AF, Wilcox MH, Hadvary P, Dryden M, Corey GR.

Clin Ther. 2017 Aug;39(8):1706-1718. doi: 10.1016/j.clinthera.2017.07.007. Epub 2017 Jul 27.


Intrawound application of vancomycin changes the responsible germ in elective spine surgery without significant effect on the rate of infection: a randomized prospective study.

Mirzashahi B, Chehrassan M, Mortazavi SMJ.

Musculoskelet Surg. 2018 Apr;102(1):35-39. doi: 10.1007/s12306-017-0490-z. Epub 2017 Jul 11.


The effects of amoxicillin and vancomycin on parameters reflecting cholesterol metabolism.

Baumgartner S, Reijnders D, Konings MCJM, Groen AK, Lütjohann D, Goossens GH, Blaak EE, Plat J.

Chem Phys Lipids. 2017 Oct;207(Pt B):239-245. doi: 10.1016/j.chemphyslip.2017.06.006. Epub 2017 Jun 21.


In Vitro Activity of Delafloxacin and Microbiological Response against Fluoroquinolone-Susceptible and Nonsusceptible Staphylococcus aureus Isolates from Two Phase 3 Studies of Acute Bacterial Skin and Skin Structure Infections.

McCurdy S, Lawrence L, Quintas M, Woosley L, Flamm R, Tseng C, Cammarata S.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00772-17. doi: 10.1128/AAC.00772-17. Print 2017 Sep.

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