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Items: 1 to 20 of 1188

1.

Reversible cholinesterase inhibitors as pretreatment for exposure to organophosphates. A review.

Lorke DE, Petroianu GA.

J Appl Toxicol. 2018 Jul 19. doi: 10.1002/jat.3662. [Epub ahead of print] Review.

PMID:
30027640
2.

Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon.

Kuca K, Jun D, Junova L, Musilek K, Hrabinova M, da Silva JAV, Ramalho TC, Valko M, Wu Q, Nepovimova E, França TCC.

Molecules. 2018 May 7;23(5). pii: E1103. doi: 10.3390/molecules23051103.

3.

Study of the Oxime-induced Reactivation of Acetyl- and Butyrylcholinesterase of Human with Inhibition of Organophosphorus Insecticide In Vitro.

Kolesnikov AM, Yuidin MA, Nikiforov AS, Ivanov IM, Vengerovich NG, Makacheev AS.

Bull Exp Biol Med. 2018 Mar;164(5):624-628. doi: 10.1007/s10517-018-4046-5. Epub 2018 Mar 26.

PMID:
29577198
4.

Acute intoxications among Turkish children.

Kizilyildiz BS, Karaman K, Özen S, Üner A.

Minerva Pediatr. 2018 Feb;70(1):46-50. doi: 10.23736/S0026-4946.16.04254-7.

PMID:
29363292
5.

Post-exposure treatment with the oxime RS194B rapidly reactivates and reverses advanced symptoms of lethal inhaled paraoxon in macaques.

Rosenberg YJ, Wang J, Ooms T, Rajendran N, Mao L, Jiang X, Lees J, Urban L, Momper JD, Sepulveda Y, Shyong YJ, Taylor P.

Toxicol Lett. 2018 Sep 1;293:229-234. doi: 10.1016/j.toxlet.2017.10.025. Epub 2017 Nov 9.

PMID:
29129799
6.

The efficacy of HI-6 DMS in a sustained infusion against percutaneous VX poisoning in the guinea-pig.

Whitmore C, Cook AR, Mann T, Price ME, Emery E, Roughley N, Flint D, Stubbs S, Armstrong SJ, Rice H, Tattersall JEH.

Toxicol Lett. 2018 Sep 1;293:207-215. doi: 10.1016/j.toxlet.2017.11.007. Epub 2017 Nov 10.

7.

Application of the Ugi Multicomponent Reaction in the Synthesis of Reactivators of Nerve Agent Inhibited Acetylcholinesterase.

de Koning MC, Joosen MJA, Worek F, Nachon F, van Grol M, Klaassen SD, Alkema DPW, Wille T, de Bruijn HM.

J Med Chem. 2017 Nov 22;60(22):9376-9392. doi: 10.1021/acs.jmedchem.7b01083. Epub 2017 Nov 13.

PMID:
29091431
8.

[Clinical effect of alanyl glutamine in the treatment of patients with gastrointestinal function obstacle caused by severe phorate poisoning].

Yu ZK, Gong ZJ, Jian XD, Qu AJ.

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2017 Jul 20;35(7):501-504. doi: 10.3760/cma.j.issn.1001-9391.2017.07.006. Chinese.

PMID:
29081098
9.

In Vitro Cysteine Reactivates Organophosphate Insecticide Dichlorvos-Inhibited Human Cholinesterases.

Mohammadi H, Jalilian J, Karimi MY, Shetab-Boushehri SV.

Sultan Qaboos Univ Med J. 2017 Aug;17(3):e293-e300. doi: 10.18295/squmj.2017.17.03.006. Epub 2017 Oct 10. Erratum in: Sultan Qaboos Univ Med J. 2017 Nov;17 (4):e493.

10.

In vitro pharmacological characterization of the bispyridinium non-oxime compound MB327 and its 2- and 3-regioisomers.

Niessen KV, Seeger T, Rappenglück S, Wein T, Höfner G, Wanner KT, Thiermann H, Worek F.

Toxicol Lett. 2018 Sep 1;293:190-197. doi: 10.1016/j.toxlet.2017.10.009. Epub 2017 Oct 10.

PMID:
29024789
11.

Involvement of superoxide in malaoxon-induced toxicity in primary cultures of cortical neurons.

Rieger DK, Dos Santos AA, Suñol C, Farina M.

J Toxicol Environ Health A. 2017;80(19-21):1106-1115. doi: 10.1080/15287394.2017.1357305. Epub 2017 Aug 29.

PMID:
28849997
12.

In silico and in vitro evaluation of two novel oximes (K378 and K727) in comparison to K-27 and pralidoxime against paraoxon-ethyl intoxication.

Arshad M, Fatmi MQ, Musilek K, Hussain A, Kuca K, Petroianu G, Kalasz H, Nurulain SM.

Toxicol Mech Methods. 2018 Jan;28(1):62-68. doi: 10.1080/15376516.2017.1357777. Epub 2017 Aug 4.

PMID:
28722512
13.

2,3-Butandione 2-monoxime inhibits skeletal myosin II by accelerating ATP cleavage.

Komatsu H, Koseki Y, Kanno T, Aoki S, Kodama T.

Biochem Biophys Res Commun. 2017 Aug 26;490(3):849-854. doi: 10.1016/j.bbrc.2017.06.130. Epub 2017 Jun 22.

PMID:
28648599
14.

Intraosseous administration of antidotes - a systematic review.

Elliott A, Dubé PA, Cossette-Côté A, Patakfalvi L, Villeneuve E, Morris M, Gosselin S.

Clin Toxicol (Phila). 2017 Dec;55(10):1025-1054. doi: 10.1080/15563650.2017.1337122. Epub 2017 Jun 23. Review.

PMID:
28644688
15.

Effect of administration method, animal weight and age on the intranasal delivery of drugs to the brain.

Krishnan JKS, Arun P, Chembukave B, Appu AP, Vijayakumar N, Moffett JR, Puthillathu N, Namboodiri AMA.

J Neurosci Methods. 2017 Jul 15;286:16-21. doi: 10.1016/j.jneumeth.2017.05.012. Epub 2017 May 10.

16.

Functional Chemical Groups that May Likely Become a Source for the Synthesis of Novel Central Nervous System (CNS) Acting Drugs.

Saganuwan SA.

Cent Nerv Syst Agents Med Chem. 2017;17(3):178-186. doi: 10.2174/1871524917666170502153752. Review.

PMID:
28464765
17.

Stereospecific cholinesterase inhibition by O,S-diethylphenylphosphonothioate.

Mohammed A, Sneathen J, Frojen SG, Kuo L, Dupureur CM.

Bioorg Med Chem. 2017 Jun 15;25(12):3053-3058. doi: 10.1016/j.bmc.2017.03.058. Epub 2017 Mar 30.

PMID:
28404526
18.

Toxic megacolon as a rare complication following atropine therapy due to organophosphate poisoning: A case report.

Mostafazadeh B, Farzaneh E, Paeezi M, Nikkhah F.

Med Leg J. 2017 Dec;85(4):221-223. doi: 10.1177/0025817217703520. Epub 2017 Apr 13.

PMID:
28403672
19.

Editor's Highlight: Spatiotemporal Progression and Remission of Lesions in the Rat Brain Following Acute Intoxication With Diisopropylfluorophosphate.

Sisó S, Hobson BA, Harvey DJ, Bruun DA, Rowland DJ, Garbow JR, Lein PJ.

Toxicol Sci. 2017 Jun 1;157(2):330-341. doi: 10.1093/toxsci/kfx048.

20.

From the Cover: MagneticResonance Imaging Reveals Progressive Brain Injury in Rats Acutely Intoxicated With Diisopropylfluorophosphate.

Hobson BA, Sisó S, Rowland DJ, Harvey DJ, Bruun DA, Garbow JR, Lein PJ.

Toxicol Sci. 2017 Jun 1;157(2):342-353. doi: 10.1093/toxsci/kfx049.

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