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Items: 20

1.

BDNF mimetic alleviates body weight gain in obese mice by enhancing mitochondrial biogenesis in skeletal muscle.

Wood J, Tse MCL, Yang X, Brobst D, Liu Z, Pang BPS, Chan WS, Zaw AM, Chow BKC, Ye K, Lee CW, Chan CB.

Metabolism. 2018 Oct;87:113-122. doi: 10.1016/j.metabol.2018.06.007. Epub 2018 Jun 20.

PMID:
29935237
2.

The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer's disease.

Chen C, Wang Z, Zhang Z, Liu X, Kang SS, Zhang Y, Ye K.

Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):578-583. doi: 10.1073/pnas.1718683115. Epub 2018 Jan 2.

3.

7,8-dihydroxyflavone protects 6-OHDA and MPTP induced dopaminergic neurons degeneration through activation of TrkB in rodents.

Luo D, Shi Y, Wang J, Lin Q, Sun Y, Ye K, Yan Q, Zhang H.

Neurosci Lett. 2016 May 4;620:43-9. doi: 10.1016/j.neulet.2016.03.042. Epub 2016 Mar 24.

PMID:
27019033
4.

Cognitive impairments following cranial irradiation can be mitigated by treatment with a tropomyosin receptor kinase B agonist.

Yang P, Leu D, Ye K, Srinivasan C, Fike JR, Huang TT.

Exp Neurol. 2016 May;279:178-186. doi: 10.1016/j.expneurol.2016.02.021. Epub 2016 Mar 2.

5.

7,8-dihydroxyflavone, a small molecular TrkB agonist, is useful for treating various BDNF-implicated human disorders.

Liu C, Chan CB, Ye K.

Transl Neurodegener. 2016 Jan 6;5:2. doi: 10.1186/s40035-015-0048-7. eCollection 2016. Review.

6.

Activation of muscular TrkB by its small molecular agonist 7,8-dihydroxyflavone sex-dependently regulates energy metabolism in diet-induced obese mice.

Chan CB, Tse MC, Liu X, Zhang S, Schmidt R, Otten R, Liu L, Ye K.

Chem Biol. 2015 Mar 19;22(3):355-68. doi: 10.1016/j.chembiol.2015.02.003. Epub 2015 Mar 5.

7.

Biochemical and biophysical investigation of the brain-derived neurotrophic factor mimetic 7,8-dihydroxyflavone in the binding and activation of the TrkB receptor.

Liu X, Obianyo O, Chan CB, Huang J, Xue S, Yang JJ, Zeng F, Goodman M, Ye K.

J Biol Chem. 2014 Oct 3;289(40):27571-84. doi: 10.1074/jbc.M114.562561. Epub 2014 Aug 20.

8.

Small-molecule trkB agonists promote axon regeneration in cut peripheral nerves.

English AW, Liu K, Nicolini JM, Mulligan AM, Ye K.

Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16217-22. doi: 10.1073/pnas.1303646110. Epub 2013 Sep 16.

9.

7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease.

Zhang Z, Liu X, Schroeder JP, Chan CB, Song M, Yu SP, Weinshenker D, Ye K.

Neuropsychopharmacology. 2014 Feb;39(3):638-50. doi: 10.1038/npp.2013.243. Epub 2013 Sep 11.

10.

Protection of spiral ganglion neurons from degeneration using small-molecule TrkB receptor agonists.

Yu Q, Chang Q, Liu X, Wang Y, Li H, Gong S, Ye K, Lin X.

J Neurosci. 2013 Aug 7;33(32):13042-52. doi: 10.1523/JNEUROSCI.0854-13.2013.

11.

TrkB receptor agonist 7, 8 dihydroxyflavone triggers profound gender- dependent neuroprotection in mice after perinatal hypoxia and ischemia.

Uluc K, Kendigelen P, Fidan E, Zhang L, Chanana V, Kintner D, Akture E, Song C, Ye K, Sun D, Ferrazzano P, Cengiz P.

CNS Neurol Disord Drug Targets. 2013 May 1;12(3):360-70.

12.

Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease.

Jiang M, Peng Q, Liu X, Jin J, Hou Z, Zhang J, Mori S, Ross CA, Ye K, Duan W.

Hum Mol Genet. 2013 Jun 15;22(12):2462-70. doi: 10.1093/hmg/ddt098. Epub 2013 Feb 27.

13.

O-methylated metabolite of 7,8-dihydroxyflavone activates TrkB receptor and displays antidepressant activity.

Liu X, Qi Q, Xiao G, Li J, Luo HR, Ye K.

Pharmacology. 2013;91(3-4):185-200. doi: 10.1159/000346920. Epub 2013 Feb 21.

14.

Optimization of a small tropomyosin-related kinase B (TrkB) agonist 7,8-dihydroxyflavone active in mouse models of depression.

Liu X, Chan CB, Qi Q, Xiao G, Luo HR, He X, Ye K.

J Med Chem. 2012 Oct 11;55(19):8524-37. doi: 10.1021/jm301099x. Epub 2012 Oct 3.

15.

Novel small molecule activators of the Trk family of receptor tyrosine kinases.

Obianyo O, Ye K.

Biochim Biophys Acta. 2013 Oct;1834(10):2213-8. doi: 10.1016/j.bbapap.2012.08.021. Epub 2012 Sep 6. Review.

16.

7,8-dihydroxyflavone exhibits therapeutic efficacy in a mouse model of Rett syndrome.

Johnson RA, Lam M, Punzo AM, Li H, Lin BR, Ye K, Mitchell GS, Chang Q.

J Appl Physiol (1985). 2012 Mar;112(5):704-10. doi: 10.1152/japplphysiol.01361.2011. Epub 2011 Dec 22.

17.

Effect of 7,8-dihydroxyflavone, a small-molecule TrkB agonist, on emotional learning.

Andero R, Heldt SA, Ye K, Liu X, Armario A, Ressler KJ.

Am J Psychiatry. 2011 Feb;168(2):163-72. doi: 10.1176/appi.ajp.2010.10030326. Epub 2010 Dec 1.

18.

A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect.

Liu X, Chan CB, Jang SW, Pradoldej S, Huang J, He K, Phun LH, France S, Xiao G, Jia Y, Luo HR, Ye K.

J Med Chem. 2010 Dec 9;53(23):8274-86. doi: 10.1021/jm101206p. Epub 2010 Nov 12.

19.

A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone.

Jang SW, Liu X, Yepes M, Shepherd KR, Miller GW, Liu Y, Wilson WD, Xiao G, Blanchi B, Sun YE, Ye K.

Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2687-92. doi: 10.1073/pnas.0913572107. Epub 2010 Jan 25.

20.

Prelimbic cortical BDNF is required for memory of learned fear but not extinction or innate fear.

Choi DC, Maguschak KA, Ye K, Jang SW, Myers KM, Ressler KJ.

Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2675-80. doi: 10.1073/pnas.0909359107. Epub 2010 Jan 25.

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