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Items: 1 to 20 of 96


Expanding Neutrophil Horizons: New Concepts in Inflammation.

Chatfield SM, Thieblemont N, Witko-Sarsat V.

J Innate Immun. 2018;10(5-6):422-431. doi: 10.1159/000493101. Epub 2018 Sep 26. Review.


Regulation of macrophage activation by proteins expressed on apoptotic neutrophils: Subversion towards autoimmunity by proteinase 3.

Thieblemont N, Witko-Sarsat V, Ariel A.

Eur J Clin Invest. 2018 Nov;48 Suppl 2:e12990. doi: 10.1111/eci.12990. Review.


Proteinase 3 Interferes With C1q-Mediated Clearance of Apoptotic Cells.

Tacnet-Delorme P, Gabillet J, Chatfield S, Thieblemont N, Frachet P, Witko-Sarsat V.

Front Immunol. 2018 Apr 25;9:818. doi: 10.3389/fimmu.2018.00818. eCollection 2018.


mTOR pathway is activated in endothelial cells from patients with Takayasu arteritis and is modulated by serum immunoglobulin G.

Hadjadj J, Canaud G, Mirault T, Samson M, Bruneval P, Régent A, Goulvestre C, Witko-Sarsat V, Costedoat-Chalumeau N, Guillevin L, Mouthon L, Terrier B; French Vasculitis Study Group.

Rheumatology (Oxford). 2018 Jun 1;57(6):1011-1020. doi: 10.1093/rheumatology/key017.


Transgenic Mice Expressing Human Proteinase 3 Exhibit Sustained Neutrophil-Associated Peritonitis.

Martin KR, Pederzoli-Ribeil M, Pacreau E, Burgener SS, Dahdah A, Candalh C, Lauret E, Foretz M, Mouthon L, Lucas B, Thieblemont N, Benarafa C, Launay P, Witko-Sarsat V.

J Immunol. 2017 Dec 1;199(11):3914-3924. doi: 10.4049/jimmunol.1601522. Epub 2017 Oct 27.


Harnessing Neutrophil Survival Mechanisms during Chronic Infection by Pseudomonas aeruginosa: Novel Therapeutic Targets to Dampen Inflammation in Cystic Fibrosis.

Marteyn BS, Burgel PR, Meijer L, Witko-Sarsat V.

Front Cell Infect Microbiol. 2017 Jun 30;7:243. doi: 10.3389/fcimb.2017.00243. eCollection 2017. Review.


Proteinase 3: the odd one out that became an autoantigen.

Martin KR, Witko-Sarsat V.

J Leukoc Biol. 2017 Sep;102(3):689-698. doi: 10.1189/jlb.3MR0217-069R. Epub 2017 May 25. Review.


Granulomatosis with polyangiitis (Wegener granulomatosis): A proteinase-3 driven disease?

Witko-Sarsat V, Thieblemont N.

Joint Bone Spine. 2018 Mar;85(2):185-189. doi: 10.1016/j.jbspin.2017.05.004. Epub 2017 May 8.


Molecular analysis of vascular smooth muscle cells from patients with giant cell arteritis: Targeting endothelin-1 receptor to control proliferation.

Régent A, Ly KH, Groh M, Khifer C, Lofek S, Clary G, Chafey P, Baud V, Broussard C, Federici C, Labrousse F, Mesturoux L, Le Jeunne C, Vidal E, Brezin A, Witko-Sarsat V, Guillevin L, Mouthon L.

Autoimmun Rev. 2017 Apr;16(4):398-406. doi: 10.1016/j.autrev.2017.02.006. Epub 2017 Feb 14. Review.


Cytoplasmic proliferating cell nuclear antigen connects glycolysis and cell survival in acute myeloid leukemia.

Ohayon D, De Chiara A, Chapuis N, Candalh C, Mocek J, Ribeil JA, Haddaoui L, Ifrah N, Hermine O, Bouillaud F, Frachet P, Bouscary D, Witko-Sarsat V.

Sci Rep. 2016 Oct 19;6:35561. doi: 10.1038/srep35561.


Proliferating cell nuclear antigen in neutrophil fate.

Witko-Sarsat V, Ohayon D.

Immunol Rev. 2016 Sep;273(1):344-56. doi: 10.1111/imr.12449. Review.


Anoxia and glucose supplementation preserve neutrophil viability and function.

Monceaux V, Chiche-Lapierre C, Chaput C, Witko-Sarsat V, Prevost MC, Taylor CT, Ungeheuer MN, Sansonetti PJ, Marteyn BS.

Blood. 2016 Aug 18;128(7):993-1002. doi: 10.1182/blood-2015-11-680918. Epub 2016 Jul 8.


[Proteinase 3: a new danger signal and a double agent in vasculitis].

Witko-Sarsat V, Perruche S.

Med Sci (Paris). 2016 May;32(5):450-2. doi: 10.1051/medsci/20163205008. Epub 2016 May 25. French. No abstract available.


From Starfish Oocytes to Inflammation: The Unforeseeable Destiny of Roscovitine in Cystic Fibrosis.

Witko-Sarsat V.

J Innate Immun. 2016;8(4):327-9. doi: 10.1159/000445967. Epub 2016 Apr 26. No abstract available.


Human neutrophils in auto-immunity.

Thieblemont N, Wright HL, Edwards SW, Witko-Sarsat V.

Semin Immunol. 2016 Apr;28(2):159-73. doi: 10.1016/j.smim.2016.03.004. Epub 2016 Mar 29. Review.


Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis.

Meijer L, Nelson DJ, Riazanski V, Gabdoulkhakova AG, Hery-Arnaud G, Le Berre R, Loaëc N, Oumata N, Galons H, Nowak E, Gueganton L, Dorothée G, Prochazkova M, Hall B, Kulkarni AB, Gray RD, Rossi AG, Witko-Sarsat V, Norez C, Becq F, Ravel D, Mottier D, Rault G.

J Innate Immun. 2016;8(4):330-49. doi: 10.1159/000444256. Epub 2016 Mar 18. Review.


Proteinase 3 Is a Phosphatidylserine-binding Protein That Affects the Production and Function of Microvesicles.

Martin KR, Kantari-Mimoun C, Yin M, Pederzoli-Ribeil M, Angelot-Delettre F, Ceroi A, Grauffel C, Benhamou M, Reuter N, Saas P, Frachet P, Boulanger CM, Witko-Sarsat V.

J Biol Chem. 2016 May 13;291(20):10476-89. doi: 10.1074/jbc.M115.698639. Epub 2016 Mar 9.


Neutrophil-Expressed p21/waf1 Favors Inflammation Resolution in Pseudomonas aeruginosa Infection.

Martin C, Ohayon D, Alkan M, Mocek J, Pederzoli-Ribeil M, Candalh C, Thevenot G, Millet A, Tamassia N, Cassatella MA, Thieblemont N, Burgel PR, Witko-Sarsat V.

Am J Respir Cell Mol Biol. 2016 May;54(5):740-50. doi: 10.1165/rcmb.2015-0047OC.


Dividing the Janus vasculitis? Pathophysiology of eosinophilic granulomatosis with polyangitis.

Chaigne B, Terrier B, Thieblemont N, Witko-Sarsat V, Mouthon L.

Autoimmun Rev. 2016 Feb;15(2):139-45. doi: 10.1016/j.autrev.2015.10.006. Epub 2015 Oct 23. Review.


Proteinase 3 on apoptotic cells disrupts immune silencing in autoimmune vasculitis.

Millet A, Martin KR, Bonnefoy F, Saas P, Mocek J, Alkan M, Terrier B, Kerstein A, Tamassia N, Satyanarayanan SK, Ariel A, Ribeil JA, Guillevin L, Cassatella MA, Mueller A, Thieblemont N, Lamprecht P, Mouthon L, Perruche S, Witko-Sarsat V.

J Clin Invest. 2015 Nov 2;125(11):4107-21. doi: 10.1172/JCI78182. Epub 2015 Oct 5.

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