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The presubiculum is preserved from neurodegenerative changes in Alzheimer's disease.

Murray CE, Gami-Patel P, Gkanatsiou E, Brinkmalm G, Portelius E, Wirths O, Heywood W, Blennow K, Ghiso J, Holton JL, Mills K, Zetterberg H, Revesz T, Lashley T.

Acta Neuropathol Commun. 2018 Jul 20;6(1):62. doi: 10.1186/s40478-018-0563-8.


Synergistic Effect on Neurodegeneration by N-Truncated Aβ4-42 and Pyroglutamate Aβ3-42 in a Mouse Model of Alzheimer's Disease.

Lopez-Noguerola JS, Giessen NME, Ueberück M, Meißner JN, Pelgrim CE, Adams J, Wirths O, Bouter Y, Bayer TA.

Front Aging Neurosci. 2018 Mar 8;10:64. doi: 10.3389/fnagi.2018.00064. eCollection 2018.


Altered neurogenesis in mouse models of Alzheimer disease.

Wirths O.

Neurogenesis (Austin). 2017 May 9;4(1):e1327002. doi: 10.1080/23262133.2017.1327002. eCollection 2017. Review.


N-truncated Aβ4-x peptides in sporadic Alzheimer's disease cases and transgenic Alzheimer mouse models.

Wirths O, Walter S, Kraus I, Klafki HW, Stazi M, Oberstein TJ, Ghiso J, Wiltfang J, Bayer TA, Weggen S.

Alzheimers Res Ther. 2017 Oct 4;9(1):80. doi: 10.1186/s13195-017-0309-z.


Limited Effects of Prolonged Environmental Enrichment on the Pathology of 5XFAD Mice.

Hüttenrauch M, Walter S, Kaufmann M, Weggen S, Wirths O.

Mol Neurobiol. 2017 Oct;54(8):6542-6555. doi: 10.1007/s12035-016-0167-x. Epub 2016 Oct 12.


Effects of Long-Term Environmental Enrichment on Anxiety, Memory, Hippocampal Plasticity and Overall Brain Gene Expression in C57BL6 Mice.

Hüttenrauch M, Salinas G, Wirths O.

Front Mol Neurosci. 2016 Aug 3;9:62. doi: 10.3389/fnmol.2016.00062. eCollection 2016.


Physical activity delays hippocampal neurodegeneration and rescues memory deficits in an Alzheimer disease mouse model.

Hüttenrauch M, Brauß A, Kurdakova A, Borgers H, Klinker F, Liebetanz D, Salinas-Riester G, Wiltfang J, Klafki HW, Wirths O.

Transl Psychiatry. 2016 May 3;6:e800. doi: 10.1038/tp.2016.65.


Deposition of C-terminally truncated Aβ species Aβ37 and Aβ39 in Alzheimer's disease and transgenic mouse models.

Reinert J, Richard BC, Klafki HW, Friedrich B, Bayer TA, Wiltfang J, Kovacs GG, Ingelsson M, Lannfelt L, Paetau A, Bergquist J, Wirths O.

Acta Neuropathol Commun. 2016 Mar 8;4:24. doi: 10.1186/s40478-016-0294-7.


Phosphorylation of the amyloid β-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity.

Kumar S, Wirths O, Stüber K, Wunderlich P, Koch P, Theil S, Rezaei-Ghaleh N, Zweckstetter M, Bayer TA, Brüstle O, Thal DR, Walter J.

Acta Neuropathol. 2016 Apr;131(4):525-37. doi: 10.1007/s00401-016-1546-0. Epub 2016 Feb 22.


The Cannabinoid CB1/CB2 Agonist WIN55212.2 Promotes Oligodendrocyte Differentiation In Vitro and Neuroprotection During the Cuprizone-Induced Central Nervous System Demyelination.

Tomas-Roig J, Wirths O, Salinas-Riester G, Havemann-Reinecke U.

CNS Neurosci Ther. 2016 May;22(5):387-95. doi: 10.1111/cns.12506. Epub 2016 Feb 4.


Endogenous Apolipoprotein E (ApoE) Fragmentation Is Linked to Amyloid Pathology in Transgenic Mouse Models of Alzheimer's Disease.

Saul A, Wirths O.

Mol Neurobiol. 2017 Jan;54(1):319-327. doi: 10.1007/s12035-015-9674-4. Epub 2016 Jan 7.


Gene Expression Profiling in the APP/PS1KI Mouse Model of Familial Alzheimer's Disease.

Weissmann R, Hüttenrauch M, Kacprowski T, Bouter Y, Pradier L, Bayer TA, Kuss AW, Wirths O.

J Alzheimers Dis. 2016;50(2):397-409. doi: 10.3233/JAD-150745.


N-truncated Aβ2-X starting with position two in sporadic Alzheimer's disease cases and two Alzheimer mouse models.

Savastano A, Klafki H, Haußmann U, Oberstein TJ, Muller P, Wirths O, Wiltfang J, Bayer TA.

J Alzheimers Dis. 2016;49(1):101-10. doi: 10.3233/JAD-150394.


N-Truncated Aβ 2-X Starting with Position Two in Sporadic Alzheimer's Disease Cases and Two Alzheimer Mouse Models.

Savastano A, Klafki H, Haußmann U, Oberstein TJ, Muller P, Wirths O, Wiltfang J, Bayer TA.

J Alzheimers Dis. 2015 Sep 24. [Epub ahead of print]


Gene Dosage Dependent Aggravation of the Neurological Phenotype in the 5XFAD Mouse Model of Alzheimer's Disease.

Richard BC, Kurdakova A, Baches S, Bayer TA, Weggen S, Wirths O.

J Alzheimers Dis. 2015;45(4):1223-36. doi: 10.3233/JAD-143120.


Neprilysin deficiency alters the neuropathological and behavioral phenotype in the 5XFAD mouse model of Alzheimer's disease.

Hüttenrauch M, Baches S, Gerth J, Bayer TA, Weggen S, Wirths O.

J Alzheimers Dis. 2015;44(4):1291-302. doi: 10.3233/JAD-142463.


I716F AβPP mutation associates with the deposition of oligomeric pyroglutamate amyloid-β and α-synucleinopathy with Lewy bodies.

Sieczkowski E, Milenkovic I, Venkataramani V, Giera R, Ströbel T, Höftberger R, Liberski PP, Auff E, Wirths O, Bayer TA, Kovacs GG.

J Alzheimers Dis. 2015;44(1):103-14. doi: 10.3233/JAD-141524.


Axonal degeneration in an Alzheimer mouse model is PS1 gene dose dependent and linked to intraneuronal Aβ accumulation.

Christensen DZ, Huettenrauch M, Mitkovski M, Pradier L, Wirths O.

Front Aging Neurosci. 2014 Jun 27;6:139. doi: 10.3389/fnagi.2014.00139. eCollection 2014.


Focusing the amyloid cascade hypothesis on N-truncated Abeta peptides as drug targets against Alzheimer's disease.

Bayer TA, Wirths O.

Acta Neuropathol. 2014;127(6):787-801. doi: 10.1007/s00401-014-1287-x. Epub 2014 May 7. Review.


Deciphering the molecular profile of plaques, memory decline and neuron loss in two mouse models for Alzheimer's disease by deep sequencing.

Bouter Y, Kacprowski T, Weissmann R, Dietrich K, Borgers H, Brauß A, Sperling C, Wirths O, Albrecht M, Jensen LR, Kuss AW, Bayer TA.

Front Aging Neurosci. 2014 Apr 16;6:75. doi: 10.3389/fnagi.2014.00075. eCollection 2014.

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