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Items: 1 to 20 of 26


Modular Assembly of the Bacterial Large Ribosomal Subunit.

Davis JH, Tan YZ, Carragher B, Potter CS, Lyumkis D, Williamson JR.

Cell. 2016 Dec 1;167(6):1610-1622.e15. doi: 10.1016/j.cell.2016.11.020.


YphC and YsxC GTPases assist the maturation of the central protuberance, GTPase associated region and functional core of the 50S ribosomal subunit.

Ni X, Davis JH, Jain N, Razi A, Benlekbir S, McArthur AG, Rubinstein JL, Britton RA, Williamson JR, Ortega J.

Nucleic Acids Res. 2016 Sep 30;44(17):8442-55. doi: 10.1093/nar/gkw678. Epub 2016 Aug 2.


Binding properties of YjeQ (RsgA), RbfA, RimM and Era to assembly intermediates of the 30S subunit.

Thurlow B, Davis JH, Leong V, Moraes TF, Williamson JR, Ortega J.

Nucleic Acids Res. 2016 Nov 16;44(20):9918-9932. Epub 2016 Jul 5.


FRET Characterization of Complex Conformational Changes in a Large 16S Ribosomal RNA Fragment Site-Specifically Labeled Using Unnatural Base Pairs.

Lavergne T, Lamichhane R, Malyshev DA, Li Z, Li L, Sperling E, Williamson JR, Millar DP, Romesberg FE.

ACS Chem Biol. 2016 May 20;11(5):1347-53. doi: 10.1021/acschembio.5b00952. Epub 2016 Mar 4.


Toward a Whole-Cell Model of Ribosome Biogenesis: Kinetic Modeling of SSU Assembly.

Earnest TM, Lai J, Chen K, Hallock MJ, Williamson JR, Luthey-Schulten Z.

Biophys J. 2015 Sep 15;109(6):1117-35. doi: 10.1016/j.bpj.2015.07.030. Epub 2015 Aug 30.


Functional interaction between ribosomal protein L6 and RbgA during ribosome assembly.

Gulati M, Jain N, Davis JH, Williamson JR, Britton RA.

PLoS Genet. 2014 Oct 16;10(10):e1004694. doi: 10.1371/journal.pgen.1004694. eCollection 2014 Oct.


A combined quantitative mass spectrometry and electron microscopy analysis of ribosomal 30S subunit assembly in E. coli.

Sashital DG, Greeman CA, Lyumkis D, Potter CS, Carragher B, Williamson JR.

Elife. 2014 Oct 14;3. doi: 10.7554/eLife.04491.


Discovery of a small molecule that inhibits bacterial ribosome biogenesis.

Stokes JM, Davis JH, Mangat CS, Williamson JR, Brown ED.

Elife. 2014 Sep 18;3:e03574. doi: 10.7554/eLife.03574.


Functional domains of the 50S subunit mature late in the assembly process.

Jomaa A, Jain N, Davis JH, Williamson JR, Britton RA, Ortega J.

Nucleic Acids Res. 2014 Mar;42(5):3419-35. doi: 10.1093/nar/gkt1295. Epub 2013 Dec 13.


Characterization of the ribosome biogenesis landscape in E. coli using quantitative mass spectrometry.

Chen SS, Williamson JR.

J Mol Biol. 2013 Feb 22;425(4):767-79. doi: 10.1016/j.jmb.2012.11.040. Epub 2012 Dec 7.


Measuring the dynamics of E. coli ribosome biogenesis using pulse-labeling and quantitative mass spectrometry.

Chen SS, Sperling E, Silverman JM, Davis JH, Williamson JR.

Mol Biosyst. 2012 Oct 30;8(12):3325-34. doi: 10.1039/c2mb25310k.


Quantitation of ten 30S ribosomal assembly intermediates using fluorescence triple correlation spectroscopy.

Ridgeway WK, Millar DP, Williamson JR.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13614-9. doi: 10.1073/pnas.1204620109. Epub 2012 Aug 6.


Systematic chromosomal deletion of bacterial ribosomal protein genes.

Shoji S, Dambacher CM, Shajani Z, Williamson JR, Schultz PG.

J Mol Biol. 2011 Nov 4;413(4):751-61. doi: 10.1016/j.jmb.2011.09.004. Epub 2011 Sep 12.


Assembly of bacterial ribosomes.

Shajani Z, Sykes MT, Williamson JR.

Annu Rev Biochem. 2011;80:501-26. doi: 10.1146/annurev-biochem-062608-160432. Review.


Quantitative proteomic analysis of ribosome assembly and turnover in vivo.

Sykes MT, Shajani Z, Sperling E, Beck AH, Williamson JR.

J Mol Biol. 2010 Oct 29;403(3):331-45. doi: 10.1016/j.jmb.2010.08.005. Epub 2010 Aug 13.


Kinetic cooperativity in Escherichia coli 30S ribosomal subunit reconstitution reveals additional complexity in the assembly landscape.

Bunner AE, Beck AH, Williamson JR.

Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5417-22. doi: 10.1073/pnas.0912007107. Epub 2010 Mar 5.


The effect of ribosome assembly cofactors on in vitro 30S subunit reconstitution.

Bunner AE, Nord S, Wikström PM, Williamson JR.

J Mol Biol. 2010 Apr 23;398(1):1-7. doi: 10.1016/j.jmb.2010.02.036. Epub 2010 Feb 24.


A dominant negative mutant of the E. coli RNA helicase DbpA blocks assembly of the 50S ribosomal subunit.

Sharpe Elles LM, Sykes MT, Williamson JR, Uhlenbeck OC.

Nucleic Acids Res. 2009 Oct;37(19):6503-14. doi: 10.1093/nar/gkp711. Epub 2009 Sep 4.


Stable isotope pulse-chase monitored by quantitative mass spectrometry applied to E. coli 30S ribosome assembly kinetics.

Bunner AE, Williamson JR.

Methods. 2009 Oct;49(2):136-41. doi: 10.1016/j.ymeth.2009.06.002. Epub 2009 Jun 24.


Quantitative ESI-TOF analysis of macromolecular assembly kinetics.

Bunner AE, Trauger SA, Siuzdak G, Williamson JR.

Anal Chem. 2008 Dec 15;80(24):9379-86. doi: 10.1021/ac8020505.

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