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Items: 1 to 20 of 349

1.

Combined Proteomic and In Silico Target Identification Reveal a Role for 5-Lipoxygenase in Developmental Signaling Pathways.

Brand S, Roy S, Schröder P, Rathmer B, Roos J, Kapoor S, Patil S, Pommerenke C, Maier T, Janning P, Eberth S, Steinhilber D, Schade D, Schneider G, Kumar K, Ziegler S, Waldmann H.

Cell Chem Biol. 2018 Sep 20;25(9):1095-1106.e23. doi: 10.1016/j.chembiol.2018.05.016. Epub 2018 Jun 28.

PMID:
30251630
2.

C-H Bond Activation for the Synthesis of Heterocyclic Atropisomers Yields Hedgehog Pathway Inhibitors.

Shan G, Flegel J, Li H, Merten C, Ziegler S, Antonchick AP, Waldmann H.

Angew Chem Int Ed Engl. 2018 Oct 22;57(43):14250-14254. doi: 10.1002/anie.201809680. Epub 2018 Oct 11.

PMID:
30203905
3.

Chromopynones are pseudo natural product glucose uptake inhibitors targeting glucose transporters GLUT-1 and -3.

Karageorgis G, Reckzeh ES, Ceballos J, Schwalfenberg M, Sievers S, Ostermann C, Pahl A, Ziegler S, Waldmann H.

Nat Chem. 2018 Nov;10(11):1103-1111. doi: 10.1038/s41557-018-0132-6. Epub 2018 Sep 10.

PMID:
30202104
4.

Photoactivatable Myristic Acid Probes for UNC119-Cargo Interactions.

Kaiser N, Mejuch T, Fedoryshchak R, Janning P, Tate EW, Waldmann H.

Chembiochem. 2018 Aug 21. doi: 10.1002/cbic.201800406. [Epub ahead of print]

PMID:
30129686
5.

TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A.

Cheung SY, Henrot M, Al-Saad M, Baumann M, Muller H, Unger A, Rubaiy HN, Mathar I, Dinkel K, Nussbaumer P, Klebl B, Freichel M, Rode B, Trainor S, Clapcote SJ, Christmann M, Waldmann H, Abbas SK, Beech DJ, Vasudev NS.

Oncotarget. 2018 Jul 3;9(51):29634-29643. doi: 10.18632/oncotarget.25659. eCollection 2018 Jul 3.

6.

Discovery of the novel autophagy inhibitor aumitin that targets mitochondrial complex I.

Robke L, Futamura Y, Konstantinidis G, Wilke J, Aono H, Mahmoud Z, Watanabe N, Wu YW, Osada H, Laraia L, Waldmann H.

Chem Sci. 2018 Feb 26;9(11):3014-3022. doi: 10.1039/c7sc05040b. eCollection 2018 Mar 21.

7.

UNC119A Decreases the Membrane Binding of Myristoylated c-Src.

Erwin N, Dwivedi M, Mejuch T, Waldmann H, Winter R.

Chembiochem. 2018 Apr 27. doi: 10.1002/cbic.201800158. [Epub ahead of print]

PMID:
29700916
8.

Catalytic Enantioselective Synthesis of a Pyrrolizidine-Alkaloid-Inspired Compound Collection with Antiplasmodial Activity.

Jia ZJ, Takayama H, Futamura Y, Aono H, Bauer JO, Strohmann C, Antonchick AP, Osada H, Waldmann H.

J Org Chem. 2018 Jul 6;83(13):7033-7041. doi: 10.1021/acs.joc.7b03202. Epub 2018 Feb 20.

PMID:
29460633
9.

Enantioselective Synthesis of the Spirotropanyl Oxindole Scaffold through Bimetallic Relay Catalysis.

Jia ZJ, Shan G, Daniliuc CG, Antonchick AP, Waldmann H.

Angew Chem Int Ed Engl. 2018 Oct 26;57(44):14493-14497. doi: 10.1002/anie.201712882. Epub 2018 Mar 1.

PMID:
29419912
10.

Dynarrestin, a Novel Inhibitor of Cytoplasmic Dynein.

Höing S, Yeh TY, Baumann M, Martinez NE, Habenberger P, Kremer L, Drexler HCA, Küchler P, Reinhardt P, Choidas A, Zischinsky ML, Zischinsky G, Nandini S, Ledray AP, Ketcham SA, Reinhardt L, Abo-Rady M, Glatza M, King SJ, Nussbaumer P, Ziegler S, Klebl B, Schroer TA, Schöler HR, Waldmann H, Sterneckert J.

Cell Chem Biol. 2018 Apr 19;25(4):357-369.e6. doi: 10.1016/j.chembiol.2017.12.014. Epub 2018 Jan 27.

PMID:
29396292
11.

Target Identification and Mechanism of Action of Picolinamide and Benzamide Chemotypes with Antifungal Properties.

Pries V, Nöcker C, Khan D, Johnen P, Hong Z, Tripathi A, Keller AL, Fitz M, Perruccio F, Filipuzzi I, Thavam S, Aust T, Riedl R, Ziegler S, Bono F, Schaaf G, Bankaitis VA, Waldmann H, Hoepfner D.

Cell Chem Biol. 2018 Mar 15;25(3):279-290.e7. doi: 10.1016/j.chembiol.2017.12.007. Epub 2018 Jan 4.

PMID:
29307839
12.

Identification of an (-)-englerin A analogue, which antagonizes (-)-englerin A at TRPC1/4/5 channels.

Rubaiy HN, Seitz T, Hahn S, Choidas A, Habenberger P, Klebl B, Dinkel K, Nussbaumer P, Waldmann H, Christmann M, Beech DJ.

Br J Pharmacol. 2018 Mar;175(5):830-839. doi: 10.1111/bph.14128. Epub 2018 Jan 25.

PMID:
29247460
13.

Na+ entry through heteromeric TRPC4/C1 channels mediates (-)Englerin A-induced cytotoxicity in synovial sarcoma cells.

Muraki K, Ohnishi K, Takezawa A, Suzuki H, Hatano N, Muraki Y, Hamzah N, Foster R, Waldmann H, Nussbaumer P, Christmann M, Bon RS, Beech DJ.

Sci Rep. 2017 Dec 5;7(1):16988. doi: 10.1038/s41598-017-17303-3.

14.

Identification of cytotoxic, glutathione-reactive moieties inducing accumulation of reactive oxygen species via glutathione depletion.

Wilke J, Kawamura T, Watanabe N, Osada H, Ziegler S, Waldmann H.

Bioorg Med Chem. 2018 May 1;26(8):1453-1461. doi: 10.1016/j.bmc.2017.11.009. Epub 2017 Nov 4.

PMID:
29170028
15.

Ligand-Directed Divergent Synthesis of Carbo- and Heterocyclic Ring Systems.

Lee YC, Kumar K, Waldmann H.

Angew Chem Int Ed Engl. 2018 May 4;57(19):5212-5226. doi: 10.1002/anie.201710247. Epub 2018 Mar 6. Review.

PMID:
29105306
16.

Exploring Natural Product Fragments for Drug and Probe Discovery.

Pahl A, Waldmann H, Kumar K.

Chimia (Aarau). 2017 Oct 25;71(10):653-660. doi: 10.2533/chimia.2017.653.

PMID:
29070410
17.

Identification of novel PDEδ interacting proteins.

Küchler P, Zimmermann G, Winzker M, Janning P, Waldmann H, Ziegler S.

Bioorg Med Chem. 2018 May 1;26(8):1426-1434. doi: 10.1016/j.bmc.2017.08.033. Epub 2017 Aug 31.

PMID:
28935183
18.

Discovery of a Novel Inhibitor of the Hedgehog Signaling Pathway through Cell-based Compound Discovery and Target Prediction.

Kremer L, Schultz-Fademrecht C, Baumann M, Habenberger P, Choidas A, Klebl B, Kordes S, Schöler HR, Sterneckert J, Ziegler S, Schneider G, Waldmann H.

Angew Chem Int Ed Engl. 2017 Oct 9;56(42):13021-13025. doi: 10.1002/anie.201707394. Epub 2017 Sep 18.

PMID:
28833911
19.

Highly Enantioselective Catalytic Vinylogous Propargylation of Coumarins Yields a Class of Autophagy Inhibitors.

Xu H, Laraia L, Schneider L, Louven K, Strohmann C, Antonchick AP, Waldmann H.

Angew Chem Int Ed Engl. 2017 Sep 4;56(37):11232-11236. doi: 10.1002/anie.201706005. Epub 2017 Jul 28.

PMID:
28696533
20.

Small Molecules Inspired by the Natural Product Withanolides as Potent Inhibitors of Wnt Signaling.

Sheremet M, Kapoor S, Schröder P, Kumar K, Ziegler S, Waldmann H.

Chembiochem. 2017 Sep 19;18(18):1797-1806. doi: 10.1002/cbic.201700260. Epub 2017 Jul 31.

PMID:
28678390

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