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Expression of a Recombinant High Affinity IgG Fc Receptor by Engineered NK Cells as a Docking Platform for Therapeutic mAbs to Target Cancer Cells.

Snyder KM, Hullsiek R, Mishra HK, Mendez DC, Li Y, Rogich A, Kaufman DS, Wu J, Walcheck B.

Front Immunol. 2018 Dec 6;9:2873. doi: 10.3389/fimmu.2018.02873. eCollection 2018.


Anti-ADAM17 monoclonal antibody MEDI3622 increases IFNγ production by human NK cells in the presence of antibody-bound tumor cells.

Mishra HK, Pore N, Michelotti EF, Walcheck B.

Cancer Immunol Immunother. 2018 Sep;67(9):1407-1416. doi: 10.1007/s00262-018-2193-1. Epub 2018 Jul 5.


Ectodomain Shedding by ADAM17: Its Role in Neutrophil Recruitment and the Impairment of This Process during Sepsis.

Mishra HK, Ma J, Walcheck B.

Front Cell Infect Microbiol. 2017 Apr 25;7:138. doi: 10.3389/fcimb.2017.00138. eCollection 2017. Review.


Ectodomain shedding of the cell adhesion molecule Nectin-4 in ovarian cancer is mediated by ADAM10 and ADAM17.

Buchanan PC, Boylan KLM, Walcheck B, Heinze R, Geller MA, Argenta PA, Skubitz APN.

J Biol Chem. 2017 Apr 14;292(15):6339-6351. doi: 10.1074/jbc.M116.746859. Epub 2017 Feb 23.


Tumor-induced MDSC act via remote control to inhibit L-selectin-dependent adaptive immunity in lymph nodes.

Ku AW, Muhitch JB, Powers CA, Diehl M, Kim M, Fisher DT, Sharda AP, Clements VK, O'Loughlin K, Minderman H, Messmer MN, Ma J, Skitzki JJ, Steeber DA, Walcheck B, Ostrand-Rosenberg S, Abrams SI, Evans SS.

Elife. 2016 Dec 8;5. pii: e17375. doi: 10.7554/eLife.17375.


Targeting ADAM17 in leukocytes increases neutrophil recruitment and reduces bacterial spread during polymicrobial sepsis.

Mishra HK, Johnson TJ, Seelig DM, Walcheck B.

J Leukoc Biol. 2016 Nov;100(5):999-1004. Epub 2016 Apr 8.


ADAM17 in tumor associated leukocytes regulates inflammatory mediators and promotes mammary tumor formation.

Bohrer LR, Chaffee TS, Chuntova P, Brady NJ, Witschen PM, Kemp SE, Nelson AC, Walcheck B, Schwertfeger KL.

Genes Cancer. 2016 Jul;7(7-8):240-253. doi: 10.18632/genesandcancer.115.


Identification of an ADAM17 cleavage region in human CD16 (FcγRIII) and the engineering of a non-cleavable version of the receptor in NK cells.

Jing Y, Ni Z, Wu J, Higgins L, Markowski TW, Kaufman DS, Walcheck B.

PLoS One. 2015 Mar 27;10(3):e0121788. doi: 10.1371/journal.pone.0121788. eCollection 2015.


Regulation of CXCR2 expression and function by a disintegrin and metalloprotease-17 (ADAM17).

Mishra HK, Long C, Bahaie NS, Walcheck B.

J Leukoc Biol. 2015 Mar;97(3):447-54. doi: 10.1189/jlb.3HI0714-340R. Epub 2014 Nov 20.


ADAM17 limits the expression of CSF1R on murine hematopoietic progenitors.

Becker AM, Walcheck B, Bhattacharya D.

Exp Hematol. 2015 Jan;43(1):44-52.e1-3. doi: 10.1016/j.exphem.2014.10.001. Epub 2014 Oct 13.


Increased expression of GCNT1 is associated with altered O-glycosylation of PSA, PAP, and MUC1 in human prostate cancers.

Chen Z, Gulzar ZG, St Hill CA, Walcheck B, Brooks JD.

Prostate. 2014 Jul;74(10):1059-67. doi: 10.1002/pros.22826. Epub 2014 May 22.


Targeting natural killer cells to acute myeloid leukemia in vitro with a CD16 x 33 bispecific killer cell engager and ADAM17 inhibition.

Wiernik A, Foley B, Zhang B, Verneris MR, Warlick E, Gleason MK, Ross JA, Luo X, Weisdorf DJ, Walcheck B, Vallera DA, Miller JS.

Clin Cancer Res. 2013 Jul 15;19(14):3844-55. doi: 10.1158/1078-0432.CCR-13-0505. Epub 2013 May 20.


NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17).

Romee R, Foley B, Lenvik T, Wang Y, Zhang B, Ankarlo D, Luo X, Cooley S, Verneris M, Walcheck B, Miller J.

Blood. 2013 May 2;121(18):3599-608. doi: 10.1182/blood-2012-04-425397. Epub 2013 Mar 13.


ADAM17 cleaves CD16b (FcγRIIIb) in human neutrophils.

Wang Y, Wu J, Newton R, Bahaie NS, Long C, Walcheck B.

Biochim Biophys Acta. 2013 Mar;1833(3):680-5. doi: 10.1016/j.bbamcr.2012.11.027. Epub 2012 Dec 8.


ADAM17 activation in circulating neutrophils following bacterial challenge impairs their recruitment.

Long C, Hosseinkhani MR, Wang Y, Sriramarao P, Walcheck B.

J Leukoc Biol. 2012 Sep;92(3):667-72. doi: 10.1189/jlb.0312112. Epub 2012 May 23.


Different signaling pathways stimulate a disintegrin and metalloprotease-17 (ADAM17) in neutrophils during apoptosis and activation.

Wang Y, Robertson JD, Walcheck B.

J Biol Chem. 2011 Nov 11;286(45):38980-8. doi: 10.1074/jbc.M111.277087. Epub 2011 Sep 23.


The C-terminal domain of the novel essential protein Gcp is critical for interaction with another essential protein YeaZ of Staphylococcus aureus.

Lei T, Liang X, Yang J, Yan M, Zheng L, Walcheck B, Ji Y.

PLoS One. 2011;6(5):e20163. doi: 10.1371/journal.pone.0020163. Epub 2011 May 19.


Leukocyte ADAM17 regulates acute pulmonary inflammation.

Arndt PG, Strahan B, Wang Y, Long C, Horiuchi K, Walcheck B.

PLoS One. 2011;6(5):e19938. doi: 10.1371/journal.pone.0019938. Epub 2011 May 16.


ADAM17 activity and other mechanisms of soluble L-selectin production during death receptor-induced leukocyte apoptosis.

Wang Y, Zhang AC, Ni Z, Herrera A, Walcheck B.

J Immunol. 2010 Apr 15;184(8):4447-54. doi: 10.4049/jimmunol.0902925. Epub 2010 Mar 10.


In vivo role of leukocyte ADAM17 in the inflammatory and host responses during E. coli-mediated peritonitis.

Long C, Wang Y, Herrera AH, Horiuchi K, Walcheck B.

J Leukoc Biol. 2010 Jun;87(6):1097-101. doi: 10.1189/jlb.1109763. Epub 2010 Feb 12.

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