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Items: 1 to 20 of 77


Disruption of JAK2 in adipocytes impairs lipolysis and improves fatty liver in mice with elevated GH.

Nordstrom SM, Tran JL, Sos BC, Wagner KU, Weiss EJ.

Mol Endocrinol. 2013 Aug;27(8):1333-42. doi: 10.1210/me.2013-1110. Epub 2013 Jun 19.


Loss of Jak2 impairs endothelial function by attenuating Raf-1/MEK1/Sp-1 signaling along with altered eNOS activities.

Yang P, Zhang Y, Pang J, Zhang S, Yu Q, He L, Wagner KU, Zhou Z, Wang CY.

Am J Pathol. 2013 Aug;183(2):617-25. doi: 10.1016/j.ajpath.2013.04.007. Epub 2013 Jun 6.


Gain-of-function of Stat5 leads to excessive granulopoiesis and lethal extravasation of granulocytes to the lung.

Lin WC, Schmidt JW, Creamer BA, Triplett AA, Wagner KU.

PLoS One. 2013;8(4):e60902. doi: 10.1371/journal.pone.0060902. Epub 2013 Apr 2.


D-type Cyclins are important downstream effectors of cytokine signaling that regulate the proliferation of normal and neoplastic mammary epithelial cells.

Zhang Q, Sakamoto K, Wagner KU.

Mol Cell Endocrinol. 2014 Jan 25;382(1):583-92. doi: 10.1016/j.mce.2013.03.016. Epub 2013 Apr 4. Review.


G-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells.

Xin H, Lu R, Lee H, Zhang W, Zhang C, Deng J, Liu Y, Shen S, Wagner KU, Forman S, Jove R, Yu H.

J Biol Chem. 2013 May 10;288(19):13842-9. doi: 10.1074/jbc.M113.450049. Epub 2013 Apr 2.


Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: implications for Jak2 inhibition in humans.

Park SO, Wamsley HL, Bae K, Hu Z, Li X, Choe SW, Slayton WB, Oh SP, Wagner KU, Sayeski PP.

PLoS One. 2013;8(3):e59675. doi: 10.1371/journal.pone.0059675. Epub 2013 Mar 27.


Dormant cancer cells contribute to residual disease in a model of reversible pancreatic cancer.

Lin WC, Rajbhandari N, Liu C, Sakamoto K, Zhang Q, Triplett AA, Batra SK, Opavsky R, Felsher DW, DiMaio DJ, Hollingsworth MA, Morris JP 4th, Hebrok M, Witkiewicz AK, Brody JR, Rui H, Wagner KU.

Cancer Res. 2013 Mar 15;73(6):1821-30. doi: 10.1158/0008-5472.CAN-12-2067. Epub 2013 Mar 6.


The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses.

Bell BD, Kitajima M, Larson RP, Stoklasek TA, Dang K, Sakamoto K, Wagner KU, Kaplan DH, Reizis B, Hennighausen L, Ziegler SF.

Nat Immunol. 2013 Apr;14(4):364-71. doi: 10.1038/ni.2541. Epub 2013 Feb 24. Erratum in: Nat Immunol. 2014 Mar;15(3):305. Kaplan, Daniel H [added].


Differential effects of hydroxyurea and INC424 on mutant allele burden and myeloproliferative phenotype in a JAK2-V617F polycythemia vera mouse model.

Kubovcakova L, Lundberg P, Grisouard J, Hao-Shen H, Romanet V, Andraos R, Murakami M, Dirnhofer S, Wagner KU, Radimerski T, Skoda RC.

Blood. 2013 Feb 14;121(7):1188-99. doi: 10.1182/blood-2012-03-415646. Epub 2012 Dec 20.


Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: potential implications for diagnosis and therapy.

Rachagani S, Torres MP, Kumar S, Haridas D, Baine M, Macha MA, Kaur S, Ponnusamy MP, Dey P, Seshacharyulu P, Johansson SL, Jain M, Wagner KU, Batra SK.

J Hematol Oncol. 2012 Oct 26;5:68. doi: 10.1186/1756-8722-5-68.


Multipotent PI-MECs are the true targets of MMTV-neu tumorigenesis.

Wagner KU, Booth BW, Boulanger CA, Smith GH.

Oncogene. 2013 Mar 7;32(10):1338. doi: 10.1038/onc.2012.452. Epub 2012 Oct 8. No abstract available.


Generation of a novel MMTV-tTA transgenic mouse strain for the targeted expression of genes in the embryonic and postnatal mammary gland.

Sakamoto K, Schmidt JW, Wagner KU.

PLoS One. 2012;7(8):e43778. doi: 10.1371/journal.pone.0043778. Epub 2012 Aug 31.


Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells.

Sánchez-Bailón MP, Calcabrini A, Gómez-Domínguez D, Morte B, Martín-Forero E, Gómez-López G, Molinari A, Wagner KU, Martín-Pérez J.

Cell Signal. 2012 Jun;24(6):1276-86.


A knockout of the Tsg101 gene leads to decreased expression of ErbB receptor tyrosine kinases and induction of autophagy prior to cell death.

Morris CR, Stanton MJ, Manthey KC, Oh KB, Wagner KU.

PLoS One. 2012;7(3):e34308. doi: 10.1371/journal.pone.0034308. Epub 2012 Mar 30.


BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia.

Hantschel O, Warsch W, Eckelhart E, Kaupe I, Grebien F, Wagner KU, Superti-Furga G, Sexl V.

Nat Chem Biol. 2012 Jan 29;8(3):285-93. doi: 10.1038/nchembio.775.


The two faces of Janus kinases and their respective STATs in mammary gland development and cancer.

Wagner KU, Schmidt JW.

J Carcinog. 2011;10:32. doi: 10.4103/1477-3163.90677. Epub 2011 Dec 8.


Hepatocyte-specific deletion of Janus kinase 2 (JAK2) protects against diet-induced steatohepatitis and glucose intolerance.

Shi SY, Martin RG, Duncan RE, Choi D, Lu SY, Schroer SA, Cai EP, Luk CT, Hopperton KE, Domenichiello AF, Tang C, Naples M, Dekker MJ, Giacca A, Adeli K, Wagner KU, Bazinet RP, Woo M.

J Biol Chem. 2012 Mar 23;287(13):10277-88. doi: 10.1074/jbc.M111.317453. Epub 2012 Jan 24.


Putting the brakes on mammary tumorigenesis: loss of STAT1 predisposes to intraepithelial neoplasias.

Schneckenleithner C, Bago-Horvath Z, Dolznig H, Neugebauer N, Kollmann K, Kolbe T, Decker T, Kerjaschki D, Wagner KU, Müller M, Stoiber D, Sexl V.

Oncotarget. 2011 Dec;2(12):1043-54.


Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis.

Hlady RA, Novakova S, Opavska J, Klinkebiel D, Peters SL, Bies J, Hannah J, Iqbal J, Anderson KM, Siebler HM, Smith LM, Greiner TC, Bastola D, Joshi S, Lockridge O, Simpson MA, Felsher DW, Wagner KU, Chan WC, Christman JK, Opavsky R.

J Clin Invest. 2012 Jan;122(1):163-77. doi: 10.1172/JCI57292. Epub 2011 Dec 1.


Cyclin D3 compensates for the loss of cyclin D1 during ErbB2-induced mammary tumor initiation and progression.

Zhang Q, Sakamoto K, Liu C, Triplett AA, Lin WC, Rui H, Wagner KU.

Cancer Res. 2011 Dec 15;71(24):7513-24. doi: 10.1158/0008-5472.CAN-11-1783. Epub 2011 Oct 28.

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