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J Rheumatol. 2015 Mar;42(3):386-90. doi: 10.3899/jrheum.140982. Epub 2015 Jan 15.

High degree of nonadherence to disease-modifying antirheumatic drugs in patients with rheumatoid arthritis.

Author information

1
From the Department of Internal Medicine 3 and the Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany; and the Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands.V. Rauscher, Medical Student; M. Englbrecht, Dipl.-Psych. Univ.; G. Schett, MD, Professor; A.J. Hueber, MD, PhD, Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg; D. van der Heijde, MD, Professor, Department of Rheumatology, Leiden University Medical Center.
2
From the Department of Internal Medicine 3 and the Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany; and the Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands.V. Rauscher, Medical Student; M. Englbrecht, Dipl.-Psych. Univ.; G. Schett, MD, Professor; A.J. Hueber, MD, PhD, Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg; D. van der Heijde, MD, Professor, Department of Rheumatology, Leiden University Medical Center. axel.hueber@uk-erlangen.de.

Abstract

OBJECTIVE:

To test medication adherence using the Compliance-Questionnaire-Rheumatology (CQR).

METHODS:

Invitation letter and CQR were sent to 240 patients with rheumatoid arthritis. Followup CQR was sent 3 months later. Adherence was evaluated using CQR 80% cutoff scores.

RESULTS:

Seventy-eight patients who were being treated with disease-modifying antirheumatic drugs provided full information on the CQR at both points in time. Eleven patients (14.1%) were classified as adherent based on taking compliance (TC), with only 3 patients (3.8%) adherent in regard to correct dosing (CD) [followup: 13 (16.7%) and 3 (3.8%) for TC and CD, respectively]. Nonadherence was not related to disease activity or side effects.

CONCLUSION:

We demonstrated low adherence, suggesting differences between doctors' records and patients' practice of antirheumatic drug therapy.

KEYWORDS:

ADHERENCE; COMPLIANCE; CQR; DISEASE-MODIFYING ANTIRHEUMATIC DRUGS; RHEUMATOID ARTHRITIS

PMID:
25593229
DOI:
10.3899/jrheum.140982
[Indexed for MEDLINE]

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