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Clin Gastroenterol Hepatol. 2019 Jul 25. pii: S1542-3565(19)30783-9. doi: 10.1016/j.cgh.2019.07.039. [Epub ahead of print]

Patterns of Cannabis Use in Patients With Cyclic Vomiting Syndrome.

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Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin. Electronic address:
Pharmacology and Toxicology, Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
Division of Biostatistics, Medical College of Wisconsin, Milwaukee, Wisconsin.
Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.



Some patients with cyclic vomiting syndrome (CVS) use cannabis to relieve stress and for its antiemetic properties. However, chronic cannabis use has been associated paradoxically with cannabinoid hyperemesis syndrome (CHS) and some patients with CVS are thought to have CHS. We sought to characterize patterns of cannabis use by patients with CVS and identify those who could be reclassified as having CHS.


We performed a cross-sectional study of 140 patients with CVS (72% female; mean age, 37 ± 13 y) seen at a specialized clinic. Patients were screened for cannabis use with the cannabis use disorder identification test. Patients were classified as regular (use ≥4 times/wk) or occasional users (<4 times/wk).


Forty-one percent of patients were current cannabis users, with 21% reporting regular use. Regular users were more likely to be male and to report an anxiety diagnosis, and smoked cannabis with higher tetrahydrocannabinol content and for a longer duration. Most users reported that cannabis helped control CVS symptoms. Among all cannabis users, 50 of 57 (88%) reported that they had abstained for longer than 1 month, but only 1 user reported resolution of CVS episodes during the abstinence period. This patient subsequently resumed using cannabis but remains free of symptoms.


Cannabis is used commonly among patients with CVS-patients report relief of symptoms with use. We found 21% of patients with CVS to be regular users, but only 1 met the Rome IV criteria for CHS. Longitudinal studies are needed to determine the relationships among cannabis use, hyperemesis, and mood symptoms.


CUDIT; Cannabinoi; Nausea; THC


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