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Curr Opin Neurobiol. 2015 Apr;31:250-3. doi: 10.1016/j.conb.2014.12.011. Epub 2015 Feb 11.

Phase organization of network computations.

Author information

1
The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address: mwilson@mit.edu.
2
The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.

Abstract

Coupled oscillations are hypothesized to organize the processing of information across distributed brain circuits. This idea is supported by recent evidence, and newly developed techniques promise to put such theoretical framework to mechanistic testing. We review evidence suggesting that individual oscillatory cycles constitute a functional unit that organizes activity in neural networks, and that oscillatory phase (defined as the fraction of the wave cycle that has elapsed relative to the start of the cycle) is a key oscillatory parameter to implement the functions of oscillations in limbic networks. We highlight neural manipulation techniques that currently allow for causal testing of these hypotheses.

PMID:
25679370
PMCID:
PMC4375010
DOI:
10.1016/j.conb.2014.12.011
[Indexed for MEDLINE]
Free PMC Article

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