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Linear pharmacokinetic parameters for monoclonal antibodies are similar within a species and across different pharmacological targets: A comparison between human, cynomolgus monkey and hFcRn Tg32 transgenic mouse using a population-modeling approach.
Betts A, Keunecke A, van Steeg TJ, van der Graaf PH, Avery LB, Jones H, Berkhout J. Betts A, et al. Among authors: van steeg tj. MAbs. 2018 Jul;10(5):751-764. doi: 10.1080/19420862.2018.1462429. Epub 2018 May 14. MAbs. 2018. PMID: 29634430 Free PMC article.
Impact of acute fat mobilisation on the pharmacokinetics of the highly fat distributed compound TAK-357, investigated by physiologically based pharmacokinetic (PBPK) modeling and simulation.
Goto A, Tagawa Y, Moriya Y, Sato S, Furukawa Y, Wakabayashi T, Tsukamoto T, DeJongh J, van Steeg TJ, Moriwaki T, Asahi S. Goto A, et al. Among authors: van steeg tj. Biopharm Drug Dispos. 2017 Sep;38(6):373-380. doi: 10.1002/bdd.2075. Epub 2017 May 23. Biopharm Drug Dispos. 2017. PMID: 28256717
16 results