Hepatitis B virus antigens made in microbial cells immunise against viral infection

K Murray; S A Bruce; A Hinnen; P Wingfield; P M van Erd; A de Reus; H Schellekens

doi:10.1002/j.1460-2075.1984.tb01861.x

Hepatitis B virus antigens made in microbial cells immunise against viral infection

EMBO J. 1984 Mar;3(3):645-50. doi: 10.1002/j.1460-2075.1984.tb01861.x.

Authors

K Murray, S A Bruce, A Hinnen, P Wingfield, P M van Erd, A de Reus, H Schellekens

Abstract

Chimpanzees have been vaccinated successfully against hepatitis B virus with preparations of the viral antigens made in microbial cells by genetic engineering methods.

MeSH terms

Animals
Cloning, Molecular
Escherichia coli / genetics
Female
Hepatitis B / prevention & control*
Hepatitis B Antigens / genetics
Hepatitis B Antigens / immunology*
Immunization
Male
Pan troglodytes
Saccharomyces cerevisiae / genetics
Viral Vaccines / immunology*

Substances

Hepatitis B Antigens
Viral Vaccines