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1987 2
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Page 1
Umbellulone modulates TRP channels.
Zhong J, Minassi A, Prenen J, Taglialatela-Scafati O, Appendino G, Nilius B. Zhong J, et al. Pflugers Arch. 2011 Dec;462(6):861-70. doi: 10.1007/s00424-011-1043-1. Epub 2011 Oct 29. Pflugers Arch. 2011. PMID: 22038323
Inhalation of umbellulone (UMB), the offensive principle of the so-called "headache tree" (California bay laurel, Umbellularia californica Nutt.), causes a painful cold sensation. ...
Inhalation of umbellulone (UMB), the offensive principle of the so-called "headache tree" (California bay laurel, Umbellularia califo …
The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system.
Nassini R, Materazzi S, Vriens J, Prenen J, Benemei S, De Siena G, la Marca G, Andrè E, Preti D, Avonto C, Sadofsky L, Di Marzo V, De Petrocellis L, Dussor G, Porreca F, Taglialatela-Scafati O, Appendino G, Nilius B, Geppetti P. Nassini R, et al. Brain. 2012 Feb;135(Pt 2):376-90. doi: 10.1093/brain/awr272. Epub 2011 Oct 27. Brain. 2012. PMID: 22036959
Umbellulone evoked a calcium-dependent release of calcitonin gene-related peptide from rodent trigeminal nerve terminals in the dura mater. In wild-type mice, umbellulone elicited excitation of trigeminal neurons and released calcitonin gene-related peptide from sen …
Umbellulone evoked a calcium-dependent release of calcitonin gene-related peptide from rodent trigeminal nerve terminals in the dura …
Dysregulation of serum prolactin links the hypothalamus with female nociceptors to promote migraine.
Watanabe M, Kopruszinski CM, Moutal A, Ikegami D, Khanna R, Chen Y, Ross S, Mackenzie K, Stratton J, Dodick DW, Navratilova E, Porreca F. Watanabe M, et al. Brain. 2022 Aug 27;145(8):2894-2909. doi: 10.1093/brain/awac104. Brain. 2022. PMID: 35325034 Free PMC article.
Repeated restraint stress promoted vulnerability (i.e. first-hit priming) to a subsequent subthreshold (i.e. second-hit) stimulus from inhalational umbellulone, a TRPA1 agonist. Periorbital cutaneous allodynia served as a surrogate of migraine-like pain. ...Stress-primed, …
Repeated restraint stress promoted vulnerability (i.e. first-hit priming) to a subsequent subthreshold (i.e. second-hit) stimulus from inhal …
Kappa opioid receptor agonists produce sexually dimorphic and prolactin-dependent hyperalgesic priming.
Kopruszinski CM, Watanabe M, Martinez AL, de Souza LHM, Dodick DW, Moutal A, Neugebauer V, Porreca F, Navratilova E. Kopruszinski CM, et al. Pain. 2023 Jun 1;164(6):e263-e273. doi: 10.1097/j.pain.0000000000002835. Epub 2022 Nov 29. Pain. 2023. PMID: 36625833
Sixteen days after the first KOR agonist administration, animals received a subthreshold dose of inhalational umbellulone, a TRPA1 agonist, as the second-hit stimulus and periorbital allodynia was assessed. ...However, repeated U-69593 downregulated the PRLR long isoform i …
Sixteen days after the first KOR agonist administration, animals received a subthreshold dose of inhalational umbellulone, a TRPA1 ag …
A novel, injury-free rodent model of vulnerability for assessment of acute and preventive therapies reveals temporal contributions of CGRP-receptor activation in migraine-like pain.
Kopruszinski CM, Navratilova E, Swiokla J, Dodick DW, Chessell IP, Porreca F. Kopruszinski CM, et al. Cephalalgia. 2021 Mar;41(3):305-317. doi: 10.1177/0333102420959794. Epub 2020 Sep 26. Cephalalgia. 2021. PMID: 32985222 Free PMC article.
RESULTS: Repeated restraint stress, but not umbellulone exposure, produced transient cutaneous allodynia that resolved within 16 d. ...Following establishment of restraint stress priming, olcegepant, but not propranolol or nor-BNI, prevented umbellulone-induced cuta …
RESULTS: Repeated restraint stress, but not umbellulone exposure, produced transient cutaneous allodynia that resolved within 16 d. . …
Hemisynthesis of dihydroumbellulols from umbellulone: new cooling compounds.
Starkenmann C, Cayeux I, Brauchli R, Mayenzet F. Starkenmann C, et al. J Agric Food Chem. 2011 Jan 26;59(2):677-83. doi: 10.1021/jf103989j. Epub 2010 Dec 29. J Agric Food Chem. 2011. PMID: 21190364
Although their occurrence was reported in Hyptis pectinata Poit, we were unable to obtain these molecules from the plant or to prove their natural occurrence. Therefore, we extracted (-)-(R)-umbellulone from Umbellularia californica Nutt. The (-)-(R)-umbellulone was …
Although their occurrence was reported in Hyptis pectinata Poit, we were unable to obtain these molecules from the plant or to prove their n …
Powerful antioxidants within Cupressus arizonica Greene female cones and leaves essential oil.
Hosseinihashemi SK, Barzegari F, Baseri H, Barbosa LCA. Hosseinihashemi SK, et al. Nat Prod Res. 2023 Nov 7:1-10. doi: 10.1080/14786419.2023.2278157. Online ahead of print. Nat Prod Res. 2023. PMID: 37933573
In contrast, the oil extracted from the leaves was rich in oxygenated monoterpenes, particularly umbellulone (17.33%). The oils extracted from the leaves exhibited remarkable DPPH radical scavenging activity, displaying a value of 95.6%. ...
In contrast, the oil extracted from the leaves was rich in oxygenated monoterpenes, particularly umbellulone (17.33%). The oils extra …
Potential mechanisms for osteopathic manipulative treatment to alleviate migraine-like pain in female rats.
Byrd K, Lund M, Pan Y, Chung BH, Child K, Fowler D, Burns-Martin J, Sanikommu M, Henderson H, Gregory C, Fleming RK, Xie JY. Byrd K, et al. Front Pain Res (Lausanne). 2024 Feb 5;5:1280589. doi: 10.3389/fpain.2024.1280589. eCollection 2024. Front Pain Res (Lausanne). 2024. PMID: 38380374 Free PMC article.
This involved bilateral injections of Complete Freund's Adjuvant (CFA) into the trapezius muscle (1st hit) followed by exposure to Umbellulone, a human migraine trigger, on Day 6 post-CFA (2nd hit). ...Immediate application of OMT after Umbellulone inhalation as an …
This involved bilateral injections of Complete Freund's Adjuvant (CFA) into the trapezius muscle (1st hit) followed by exposure to Umbell …
Comparative investigation of Umbellularia californica and Laurus nobilis leaf essential oils and identification of constituents active against Aedes aegypti.
Tabanca N, Avonto C, Wang M, Parcher JF, Ali A, Demirci B, Raman V, Khan IA. Tabanca N, et al. J Agric Food Chem. 2013 Dec 18;61(50):12283-91. doi: 10.1021/jf4052682. Epub 2013 Dec 5. J Agric Food Chem. 2013. PMID: 24266426
Thymol (LD50 = 17.6 ppm), p-cymene, (-)-umbellulone, and methyleugenol were the primary larvicidal in this oil. ...Umbellulone mosquito activity is here reported for the first time....
Thymol (LD50 = 17.6 ppm), p-cymene, (-)-umbellulone, and methyleugenol were the primary larvicidal in this oil. ...Umbellulone …
Herbalism helps headache.
Goadsby PJ. Goadsby PJ. Brain. 2012 Feb;135(Pt 2):318-9. doi: 10.1093/brain/aws008. Brain. 2012. PMID: 22345087 No abstract available.
27 results