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Indian J Pharmacol. 2015 Mar-Apr;47(2):160-6. doi: 10.4103/0253-7613.153422.

Exploring the role of curcumin containing ethanolic extract obtained from Curcuma longa (rhizomes) against retardation of wound healing process by aspirin.

Author information

1
Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, VNS Group of Institutions, Bhopal, Madhya Pradesh, India.

Abstract

AIM:

The aim of the study was to assess the curcumin containing ethanolic extract (EtOH) obtained from Curcuma longa (Cl) against retardation of wound healing by aspirin.

MATERIALS AND METHODS:

Wound healing process was retarded by administering the dose of 150 mg/kg body weight of aspirin orally for 9 days to observe the effect of EtOH obtained from Cl using excision and incision wound model in rats. The various parameters such as % wound contraction, epithelialization period, hydroxyproline, tensile strength were observed at variant time intervals and histopathological study was also performed.

RESULTS:

Curcumin containing 5% and 10% ethanolic extract ointment have shown significant (P < 0.01) wound healing activity against an aspirin (administered 150 mg/kg body weight orally for 9 days) retarded wound healing process. Topical application of ointment showed significant (P < 0.01) difference as compared to the control group. Histopathological studies also showed healing of the epidermis, increased collagen, fibroblasts and blood vessels.

CONCLUSION:

Ethanolic extract of Cl ointment (EtOHCl) containing 10% curcumin displayed remarkable healing process against wound retardation by aspirin.

KEYWORDS:

Aspirin; Curcuma longa; excision wound; incision wound; wound contraction

PMID:
25878374
PMCID:
PMC4386123
DOI:
10.4103/0253-7613.153422
[Indexed for MEDLINE]
Free PMC Article

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