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Alzheimers Dement (N Y). 2016 Aug 11;2(3):156-161. doi: 10.1016/j.trci.2016.07.002. eCollection 2016 Sep.

B-vitamins are potentially a cost-effective population health strategy to tackle dementia: Too good to be true?

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Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Oxford Project to Investigate Memory and Ageing (OPTIMA), Department of Pharmacology, University of Oxford, Oxford, UK.



To respond to the threat of dementia to public health and the economy, we need to prioritize research resources on strategies that would be the most effective. In relation to the prevention of dementia, this article considers whether lowering plasma homocysteine by B-vitamin supplementation is one of the top priority and cost-effective treatments.


A decision model was constructed to calculate the lifetime costs and quality-adjusted life years (QALYs) of providing B-vitamin treatment to people in the United Kingdom over 60 years with high levels (>13 μmol/L) of plasma homocysteine, which was compared to the lifetime costs and outcomes of not providing them with the treatment.


Treatment with B-vitamins will save £60,021 per QALY gained and so is highly cost-effective.


We anticipate that this provocative finding will be debated by scientists, clinicians, and policy makers and eventually be tested in future clinical trials.


B-Vitamins; Cost-effectiveness; Dementia; Homocysteine; UK

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