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Items: 1 to 20 of 29

1.

The shieldin complex mediates 53BP1-dependent DNA repair.

Noordermeer SM, Adam S, Setiaputra D, Barazas M, Pettitt SJ, Ling AK, Olivieri M, Álvarez-Quilón A, Moatti N, Zimmermann M, Annunziato S, Krastev DB, Song F, Brandsma I, Frankum J, Brough R, Sherker A, Landry S, Szilard RK, Munro MM, McEwan A, Goullet de Rugy T, Lin ZY, Hart T, Moffat J, Gingras AC, Martin A, van Attikum H, Jonkers J, Lord CJ, Rottenberg S, Durocher D.

Nature. 2018 Aug;560(7716):117-121. doi: 10.1038/s41586-018-0340-7. Epub 2018 Jul 18.

PMID:
30022168
2.

CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions.

Zimmermann M, Murina O, Reijns MAM, Agathanggelou A, Challis R, Tarnauskaitė Ž, Muir M, Fluteau A, Aregger M, McEwan A, Yuan W, Clarke M, Lambros MB, Paneesha S, Moss P, Chandrashekhar M, Angers S, Moffat J, Brunton VG, Hart T, de Bono J, Stankovic T, Jackson AP, Durocher D.

Nature. 2018 Jul;559(7713):285-289. doi: 10.1038/s41586-018-0291-z. Epub 2018 Jul 4.

PMID:
29973717
3.

Microdroplet PCR for Highly Multiplexed Targeted Bisulfite Sequencing.

Komori HK, LaMere SA, Hart T, Head SR, Torkamani A, Salomon DR.

Methods Mol Biol. 2018;1708:333-348. doi: 10.1007/978-1-4939-7481-8_17.

PMID:
29224152
4.

Corrigendum: Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors.

Steinhart Z, Pavlovic Z, Chandrashekhar M, Hart T, Wang X, Zhang X, Robitaille M, Brown KR, Jaksani S, Overmeer R, Boj SF, Adams J, Pan J, Clevers H, Sidhu S, Moffat J, Angers S.

Nat Med. 2017 Nov 7;23(11):1384. doi: 10.1038/nm1117-1384d.

PMID:
29117169
5.

PICKLES: the database of pooled in-vitro CRISPR knockout library essentiality screens.

Lenoir WF, Lim TL, Hart T.

Nucleic Acids Res. 2018 Jan 4;46(D1):D776-D780. doi: 10.1093/nar/gkx993.

6.

All for One, and One for All.

Kim E, Hart T.

Cell Syst. 2017 Oct 25;5(4):314-316. doi: 10.1016/j.cels.2017.10.005.

PMID:
29073370
7.

Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens.

Hart T, Tong AHY, Chan K, Van Leeuwen J, Seetharaman A, Aregger M, Chandrashekhar M, Hustedt N, Seth S, Noonan A, Habsid A, Sizova O, Nedyalkova L, Climie R, Tworzyanski L, Lawson K, Sartori MA, Alibeh S, Tieu D, Masud S, Mero P, Weiss A, Brown KR, Usaj M, Billmann M, Rahman M, Constanzo M, Myers CL, Andrews BJ, Boone C, Durocher D, Moffat J.

G3 (Bethesda). 2017 Aug 7;7(8):2719-2727. doi: 10.1534/g3.117.041277.

8.

Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors.

Steinhart Z, Pavlovic Z, Chandrashekhar M, Hart T, Wang X, Zhang X, Robitaille M, Brown KR, Jaksani S, Overmeer R, Boj SF, Adams J, Pan J, Clevers H, Sidhu S, Moffat J, Angers S.

Nat Med. 2017 Jan;23(1):60-68. doi: 10.1038/nm.4219. Epub 2016 Nov 21. Erratum in: Nat Med. 2017 Nov 7;23 (11):1384.

PMID:
27869803
9.

BAGEL: a computational framework for identifying essential genes from pooled library screens.

Hart T, Moffat J.

BMC Bioinformatics. 2016 Apr 16;17:164. doi: 10.1186/s12859-016-1015-8.

10.

Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells.

Toledo CM, Ding Y, Hoellerbauer P, Davis RJ, Basom R, Girard EJ, Lee E, Corrin P, Hart T, Bolouri H, Davison J, Zhang Q, Hardcastle J, Aronow BJ, Plaisier CL, Baliga NS, Moffat J, Lin Q, Li XN, Nam DH, Lee J, Pollard SM, Zhu J, Delrow JJ, Clurman BE, Olson JM, Paddison PJ.

Cell Rep. 2015 Dec 22;13(11):2425-2439. doi: 10.1016/j.celrep.2015.11.021. Epub 2015 Dec 7.

11.

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.

Hart T, Chandrashekhar M, Aregger M, Steinhart Z, Brown KR, MacLeod G, Mis M, Zimmermann M, Fradet-Turcotte A, Sun S, Mero P, Dirks P, Sidhu S, Roth FP, Rissland OS, Durocher D, Angers S, Moffat J.

Cell. 2015 Dec 3;163(6):1515-26. doi: 10.1016/j.cell.2015.11.015. Epub 2015 Nov 25.

12.

Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death.

Pandyra AA, Mullen PJ, Goard CA, Ericson E, Sharma P, Kalkat M, Yu R, Pong JT, Brown KR, Hart T, Gebbia M, Lang KS, Giaever G, Nislow C, Moffat J, Penn LZ.

Oncotarget. 2015 Sep 29;6(29):26909-21. doi: 10.18632/oncotarget.4817.

13.

Extensive mapping of an innate immune network with CRISPR.

Aregger M, Hart T, Moffat J.

Mol Syst Biol. 2015 Jul 24;11(7):821. doi: 10.15252/msb.20156373.

14.

Natural Variation in Gene Expression Modulates the Severity of Mutant Phenotypes.

Vu V, Verster AJ, Schertzberg M, Chuluunbaatar T, Spensley M, Pajkic D, Hart GT, Moffat J, Fraser AG.

Cell. 2015 Jul 16;162(2):391-402. doi: 10.1016/j.cell.2015.06.037.

15.

Defining CD4 T cell memory by the epigenetic landscape of CpG DNA methylation.

Komori HK, Hart T, LaMere SA, Chew PV, Salomon DR.

J Immunol. 2015 Feb 15;194(4):1565-79. doi: 10.4049/jimmunol.1401162. Epub 2015 Jan 9.

16.

Measuring error rates in genomic perturbation screens: gold standards for human functional genomics.

Hart T, Brown KR, Sircoulomb F, Rottapel R, Moffat J.

Mol Syst Biol. 2014 Jul 1;10:733. doi: 10.15252/msb.20145216.

17.

Finding the active genes in deep RNA-seq gene expression studies.

Hart T, Komori HK, LaMere S, Podshivalova K, Salomon DR.

BMC Genomics. 2013 Nov 11;14:778. doi: 10.1186/1471-2164-14-778.

18.

Scaling up the systematic hunt for mammalian genetic interactions.

Hart T, Moffat J.

Nat Methods. 2013 May;10(5):397-9. doi: 10.1038/nmeth.2449. No abstract available.

PMID:
23629415
19.

A census of human soluble protein complexes.

Havugimana PC, Hart GT, Nepusz T, Yang H, Turinsky AL, Li Z, Wang PI, Boutz DR, Fong V, Phanse S, Babu M, Craig SA, Hu P, Wan C, Vlasblom J, Dar VU, Bezginov A, Clark GW, Wu GC, Wodak SJ, Tillier ER, Paccanaro A, Marcotte EM, Emili A.

Cell. 2012 Aug 31;150(5):1068-81. doi: 10.1016/j.cell.2012.08.011.

20.

MicroRNA regulation of molecular networks mapped by global microRNA, mRNA, and protein expression in activated T lymphocytes.

Grigoryev YA, Kurian SM, Hart T, Nakorchevsky AA, Chen C, Campbell D, Head SR, Yates JR 3rd, Salomon DR.

J Immunol. 2011 Sep 1;187(5):2233-43. doi: 10.4049/jimmunol.1101233. Epub 2011 Jul 25.

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