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Tumor targeting with pH-responsive poly(2-oxazoline)-based nanogels for metronomic doxorubicin treatment.

Hoelzer D, Leiske MN, Hartlieb M, Bus T, Pretzel D, Hoeppener S, Kempe K, Thierbach R, Schubert US.

Oncotarget. 2018 Apr 27;9(32):22316-22331. doi: 10.18632/oncotarget.24806. eCollection 2018 Apr 27.


Selenoprotein H controls cell cycle progression and proliferation of human colorectal cancer cells.

Bertz M, Kühn K, Koeberle SC, Müller MF, Hoelzer D, Thies K, Deubel S, Thierbach R, Kipp AP.

Free Radic Biol Med. 2018 Nov 1;127:98-107. doi: 10.1016/j.freeradbiomed.2018.01.010. Epub 2018 Jan 9.


The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factor-dependent cell death in a p53 null Ewing's sarcoma cell line.

Marx C, Marx-Blümel L, Lindig N, Thierbach R, Hoelzer D, Becker S, Wittig S, Lehmann R, Slevogt H, Heinzel T, Wang ZQ, Beck JF, Sonnemann J.

Invest New Drugs. 2018 Jun;36(3):396-406. doi: 10.1007/s10637-017-0541-1. Epub 2017 Nov 18.


Insulin-IGF signaling affects cell transformation in the BALB/c 3T3 cell model.

Poburski D, Leovsky C, Boerner JB, Szimmtenings L, Ristow M, Glei M, Thierbach R.

Sci Rep. 2016 Nov 16;6:37120. doi: 10.1038/srep37120.


Peri-Implant Sulcus Fluid (PISF) Matrix Metalloproteinase (MMP) -8 Levels in Peri-Implantitis.

Thierbach R, Maier K, Sorsa T, Mäntylä P.

J Clin Diagn Res. 2016 May;10(5):ZC34-8. doi: 10.7860/JCDR/2016/16105.7749. Epub 2016 May 1.


Time-resolved functional analysis of acute impairment of frataxin expression in an inducible cell model of Friedreich ataxia.

Poburski D, Boerner JB, Koenig M, Ristow M, Thierbach R.

Biol Open. 2016 May 15;5(5):654-61. doi: 10.1242/bio.017004.


Use of snacks in insulin-treated people with diabetes mellitus and association with HbA1c , weight and quality of life: a cross sectional study.

Heller T, Kloos C, Keßler D, Müller N, Thierbach R, Wolf G, Müller UA.

Diabet Med. 2015 Mar;32(3):353-8. doi: 10.1111/dme.12616. Epub 2014 Nov 19.


Clinical outcome of a nonsurgical and surgical treatment protocol in different types of peri-implantitis: a case series.

Thierbach R, Eger T.

Quintessence Int. 2013 Feb;44(2):137-48. doi: 10.3290/j.qi.a28929.


Specific alterations of carbohydrate metabolism are associated with hepatocarcinogenesis in mitochondrially impaired mice.

Thierbach R, Florian S, Wolfrum K, Voigt A, Drewes G, Blume U, Bannasch P, Ristow M, Steinberg P.

Hum Mol Genet. 2012 Feb 1;21(3):656-63. doi: 10.1093/hmg/ddr499. Epub 2011 Nov 3.


Inhibition of alanine aminotransferase in silico and in vivo promotes mitochondrial metabolism to impair malignant growth.

Beuster G, Zarse K, Kaleta C, Thierbach R, Kiehntopf M, Steinberg P, Schuster S, Ristow M.

J Biol Chem. 2011 Jun 24;286(25):22323-30. doi: 10.1074/jbc.M110.205229. Epub 2011 May 3.


Activation of mitochondrial energy metabolism protects against cardiac failure.

Schulz TJ, Westermann D, Isken F, Voigt A, Laube B, Thierbach R, Kuhlow D, Zarse K, Schomburg L, Pfeiffer AF, Tschöpe C, Ristow M.

Aging (Albany NY). 2010 Nov;2(11):843-53.


The Friedreich's ataxia protein frataxin modulates DNA base excision repair in prokaryotes and mammals.

Thierbach R, Drewes G, Fusser M, Voigt A, Kuhlow D, Blume U, Schulz TJ, Reiche C, Glatt H, Epe B, Steinberg P, Ristow M.

Biochem J. 2010 Nov 15;432(1):165-72. doi: 10.1042/BJ20101116.


Automated soft agar assay for the high-throughput screening of anticancer compounds.

Thierbach R, Steinberg P.

Anal Biochem. 2009 Apr 15;387(2):318-20. doi: 10.1016/j.ab.2009.01.029. Epub 2009 Feb 11.


Glutathione Peroxidase 2 Inhibits Cyclooxygenase-2-Mediated Migration and Invasion of HT-29 Adenocarcinoma Cells but Supports Their Growth as Tumors in Nude Mice.

Banning A, Kipp A, Schmitmeier S, Löwinger M, Florian S, Krehl S, Thalmann S, Thierbach R, Steinberg P, Brigelius-Flohé R.

Cancer Res. 2008 Dec 1;68(23):9746-53. doi: 10.1158/0008-5472.CAN-08-1321.


A high-throughput reporter gene assay to prove the ability of natural compounds to modulate glutathione peroxidase, superoxide dismutase and catalase gene promoters in V79 cells.

Ullmann K, Wiencierz AM, Müller C, Thierbach R, Steege A, Toyokuni S, Steinberg P.

Free Radic Res. 2008 Aug;42(8):746-53. doi: 10.1080/10715760802337273.


Variable expression of Cre recombinase transgenes precludes reliable prediction of tissue-specific gene disruption by tail-biopsy genotyping.

Schulz TJ, Glaubitz M, Kuhlow D, Thierbach R, Birringer M, Steinberg P, Pfeiffer AF, Ristow M.

PLoS One. 2007 Oct 10;2(10):e1013.


Reduced expression of mitochondrial frataxin in mice exacerbates diet-induced obesity.

Pomplun D, Voigt A, Schulz TJ, Thierbach R, Pfeiffer AF, Ristow M.

Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6377-81. Epub 2007 Apr 2.


Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice.

Thierbach R, Schulz TJ, Isken F, Voigt A, Mietzner B, Drewes G, von Kleist-Retzow JC, Wiesner RJ, Magnuson MA, Puccio H, Pfeiffer AF, Steinberg P, Ristow M.

Hum Mol Genet. 2005 Dec 15;14(24):3857-64. Epub 2005 Nov 8. Erratum in: Hum Mol Genet. 2007 Dec 1;16(23):2987.


Induction of oxidative metabolism by mitochondrial frataxin inhibits cancer growth: Otto Warburg revisited.

Schulz TJ, Thierbach R, Voigt A, Drewes G, Mietzner B, Steinberg P, Pfeiffer AF, Ristow M.

J Biol Chem. 2006 Jan 13;281(2):977-81. Epub 2005 Nov 1.

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