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Items: 1 to 20 of 38


Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea.

Duan T, Cil O, Thiagarajah JR, Verkman AS.

JCI Insight. 2019 Feb 21;4(4). pii: 126444. doi: 10.1172/jci.insight.126444. eCollection 2019 Feb 21.


INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling.

Luong P, Hedl M, Yan J, Zuo T, Fu TM, Jiang X, Thiagarajah JR, Hansen SH, Lesser CF, Wu H, Abraham C, Lencer WI.

Elife. 2018 Oct 25;7. pii: e38539. doi: 10.7554/eLife.38539.


An Intravenous Fish Oil-Based Lipid Emulsion Successfully Treats Intractable Pruritus and Cholestasis in a Patient with Microvillous Inclusion Disease.

Anez-Bustillos L, Dao DT, Potemkin AK, Perez-Atayde AR, Raphael BP, Carey AN, Kamin DS, Thiagarajah JR, Crowley M, Gura KM, Puder M.

Hepatology. 2019 Mar;69(3):1353-1356. doi: 10.1002/hep.30311. Epub 2019 Feb 9. No abstract available.


Neonatal-Onset Chronic Diarrhea Caused by Homozygous Nonsense WNT2B Mutations.

O'Connell AE, Zhou F, Shah MS, Murphy Q, Rickner H, Kelsen J, Boyle J, Doyle JJ, Gangwani B, Thiagarajah JR, Kamin DS, Goldsmith JD, Richmond C, Breault DT, Agrawal PB.

Am J Hum Genet. 2018 Jul 5;103(1):131-137. doi: 10.1016/j.ajhg.2018.05.007. Epub 2018 Jun 14.


Advances in Evaluation of Chronic Diarrhea in Infants.

Thiagarajah JR, Kamin DS, Acra S, Goldsmith JD, Roland JT, Lencer WI, Muise AM, Goldenring JR, Avitzur Y, Martín MG; PediCODE Consortium.

Gastroenterology. 2018 Jun;154(8):2045-2059.e6. doi: 10.1053/j.gastro.2018.03.067. Epub 2018 Apr 12. Review.


Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia.

Thiagarajah JR, Chang J, Goettel JA, Verkman AS, Lencer WI.

Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):568-573. doi: 10.1073/pnas.1612921114. Epub 2017 Jan 3.


The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion.

Frank SR, Köllmann CP, van Lidth de Jeude JF, Thiagarajah JR, Engelholm LH, Frödin M, Hansen SH.

Oncogene. 2017 Mar 30;36(13):1816-1828. doi: 10.1038/onc.2016.345. Epub 2016 Sep 26.


CFTR activator increases intestinal fluid secretion and normalizes stool output in a mouse model of constipation.

Cil O, Phuan PW, Lee S, Tan J, Haggie PM, Levin MH, Sun L, Thiagarajah JR, Ma T, Verkman AS.

Cell Mol Gastroenterol Hepatol. 2016 May;2(3):317-327. Epub 2016 Jan 9.


Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion.

Saslowsky DE, Thiagarajah JR, McCormick BA, Lee JC, Lencer WI.

Mol Biol Cell. 2016 Apr 1;27(7):1120-30. doi: 10.1091/mbc.E15-05-0293. Epub 2016 Feb 10.


Congenital chloride-losing diarrhea in a Mexican child with the novel homozygous SLC26A3 mutation G393W.

Reimold FR, Balasubramanian S, Doroquez DB, Shmukler BE, Zsengeller ZK, Saslowsky D, Thiagarajah JR, Stillman IE, Lencer WI, Wu BL, Villalpando-Carrion S, Alper SL.

Front Physiol. 2015 Jun 23;6:179. doi: 10.3389/fphys.2015.00179. eCollection 2015.


Secretory diarrhoea: mechanisms and emerging therapies.

Thiagarajah JR, Donowitz M, Verkman AS.

Nat Rev Gastroenterol Hepatol. 2015 Aug;12(8):446-57. doi: 10.1038/nrgastro.2015.111. Epub 2015 Jun 30. Review.


Altered goblet cell differentiation and surface mucus properties in Hirschsprung disease.

Thiagarajah JR, Yildiz H, Carlson T, Thomas AR, Steiger C, Pieretti A, Zukerberg LR, Carrier RL, Goldstein AM.

PLoS One. 2014 Jun 19;9(6):e99944. doi: 10.1371/journal.pone.0099944. eCollection 2014.


Discovery and development of antisecretory drugs for treating diarrheal diseases.

Thiagarajah JR, Ko EA, Tradtrantip L, Donowitz M, Verkman AS.

Clin Gastroenterol Hepatol. 2014 Feb;12(2):204-9. doi: 10.1016/j.cgh.2013.12.001. Epub 2013 Dec 4. Review.


Chloride channel inhibition by a red wine extract and a synthetic small molecule prevents rotaviral secretory diarrhoea in neonatal mice.

Ko EA, Jin BJ, Namkung W, Ma T, Thiagarajah JR, Verkman AS.

Gut. 2014 Jul;63(7):1120-9. doi: 10.1136/gutjnl-2013-305663. Epub 2013 Sep 19.


Chloride channel-targeted therapy for secretory diarrheas.

Thiagarajah JR, Verkman AS.

Curr Opin Pharmacol. 2013 Dec;13(6):888-94. doi: 10.1016/j.coph.2013.08.005. Epub 2013 Aug 27. Review.


Response to "Diffusion versus convection".

Jin BJ, Thiagarajah JR, Verkman AS.

J Gen Physiol. 2013 Aug;142(2):173. doi: 10.1085/jgp.201311031. No abstract available.


Convective washout reduces the antidiarrheal efficacy of enterocyte surface-targeted antisecretory drugs.

Jin BJ, Thiagarajah JR, Verkman AS.

J Gen Physiol. 2013 Feb;141(2):261-72. doi: 10.1085/jgp.201210885.


CFTR inhibitors.

Verkman AS, Synder D, Tradtrantip L, Thiagarajah JR, Anderson MO.

Curr Pharm Des. 2013;19(19):3529-41. Review.


CFTR inhibitors for treating diarrheal disease.

Thiagarajah JR, Verkman AS.

Clin Pharmacol Ther. 2012 Sep;92(3):287-90. doi: 10.1038/clpt.2012.114. Epub 2012 Aug 1. Review.


Airway surface liquid depth imaged by surface laser reflectance microscopy.

Thiagarajah JR, Song Y, Derichs N, Verkman AS.

J Gen Physiol. 2010 Sep;136(3):353-62. doi: 10.1085/jgp.201010490. Epub 2010 Aug 16.

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