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Items: 1 to 20 of 77

1.

Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design.

Wang F, Jeon KO, Salovich JM, Macdonald JD, Alvarado J, Gogliotti RD, Phan J, Olejniczak ET, Sun Q, Wang S, Camper D, Yuh JP, Shaw JG, Sai J, Rossanese OW, Tansey WP, Stauffer SR, Fesik SW.

J Med Chem. 2018 Jul 12;61(13):5623-5642. doi: 10.1021/acs.jmedchem.8b00375. Epub 2018 Jun 29.

PMID:
29889518
2.

Phosphorylation of XIAP at threonine 180 controls its activity in Wnt signaling.

Ng VH, Hang BI, Sawyer LM, Neitzel LR, Crispi EE, Rose KL, Popay TM, Zhong A, Lee LA, Tansey WP, Huppert S, Lee E.

J Cell Sci. 2018 May 22;131(10). pii: jcs210575. doi: 10.1242/jcs.210575.

PMID:
29678905
3.

Moonlighting with WDR5: A Cellular Multitasker.

Guarnaccia AD, Tansey WP.

J Clin Med. 2018 Jan 30;7(2). pii: E21. doi: 10.3390/jcm7020021. Review.

4.

BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumourigenesis.

Parang B, Kaz AM, Barrett CW, Short SP, Ning W, Keating CE, Mittal MK, Naik RD, Washington MK, Revetta FL, Smith JJ, Chen X, Wilson KT, Brand T, Bader DM, Tansey WP, Chen R, Brentnall TA, Grady WM, Williams CS.

Gut. 2017 May;66(5):852-862. doi: 10.1136/gutjnl-2015-310255. Epub 2016 Jan 14.

5.

Interaction of Gcn4 with target gene chromatin is modulated by proteasome function.

Howard GC, Tansey WP.

Mol Biol Cell. 2016 Sep 1;27(17):2735-41. doi: 10.1091/mbc.E16-03-0192. Epub 2016 Jul 6.

6.

Antagonistic roles for the ubiquitin ligase Asr1 and the ubiquitin-specific protease Ubp3 in subtelomeric gene silencing.

McCann TS, Guo Y, McDonald WH, Tansey WP.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1309-14. doi: 10.1073/pnas.1518375113. Epub 2016 Jan 19.

7.

Interaction of MYC with host cell factor-1 is mediated by the evolutionarily conserved Myc box IV motif.

Thomas LR, Foshage AM, Weissmiller AM, Popay TM, Grieb BC, Qualls SJ, Ng V, Carboneau B, Lorey S, Eischen CM, Tansey WP.

Oncogene. 2016 Jul 7;35(27):3613-8. doi: 10.1038/onc.2015.416. Epub 2015 Nov 2.

8.

The MYC-WDR5 Nexus and Cancer.

Thomas LR, Foshage AM, Weissmiller AM, Tansey WP.

Cancer Res. 2015 Oct 1;75(19):4012-5. doi: 10.1158/0008-5472.CAN-15-1216. Epub 2015 Sep 17. Review.

9.

Do changes in the c-MYC coding sequence contribute to tumorigenesis?

Chakraborty AA, Tansey WP.

Mol Cell Oncol. 2014 Oct 30;2(2):e965631. doi: 10.4161/23723548.2014.965631. eCollection 2015 Apr-Jun.

10.

Interaction with WDR5 promotes target gene recognition and tumorigenesis by MYC.

Thomas LR, Wang Q, Grieb BC, Phan J, Foshage AM, Sun Q, Olejniczak ET, Clark T, Dey S, Lorey S, Alicie B, Howard GC, Cawthon B, Ess KC, Eischen CM, Zhao Z, Fesik SW, Tansey WP.

Mol Cell. 2015 May 7;58(3):440-52. doi: 10.1016/j.molcel.2015.02.028. Epub 2015 Mar 26.

11.

Functions of the proteasome on chromatin.

McCann TS, Tansey WP.

Biomolecules. 2014 Nov 21;4(4):1026-44. doi: 10.3390/biom4041026. Review.

12.

The ubiquitin-selective chaperone Cdc48/p97 associates with Ubx3 to modulate monoubiquitylation of histone H2B.

Bonizec M, Hérissant L, Pokrzywa W, Geng F, Wenzel S, Howard GC, Rodriguez P, Krause S, Tansey WP, Hoppe T, Dargemont C.

Nucleic Acids Res. 2014;42(17):10975-86. doi: 10.1093/nar/gku786. Epub 2014 Sep 2.

13.

Stable histone adduction by 4-oxo-2-nonenal: a potential link between oxidative stress and epigenetics.

Galligan JJ, Rose KL, Beavers WN, Hill S, Tallman KA, Tansey WP, Marnett LJ.

J Am Chem Soc. 2014 Aug 27;136(34):11864-6. doi: 10.1021/ja503604t. Epub 2014 Aug 11.

14.

A common functional consequence of tumor-derived mutations within c-MYC.

Chakraborty AA, Scuoppo C, Dey S, Thomas LR, Lorey SL, Lowe SW, Tansey WP.

Oncogene. 2015 Apr 30;34(18):2406-9. doi: 10.1038/onc.2014.186. Epub 2014 Jul 7.

15.

Similar temporal and spatial recruitment of native 19S and 20S proteasome subunits to transcriptionally active chromatin.

Geng F, Tansey WP.

Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6060-5. doi: 10.1073/pnas.1200854109. Epub 2012 Apr 2.

16.

Ubiquitin and proteasomes in transcription.

Geng F, Wenzel S, Tansey WP.

Annu Rev Biochem. 2012;81:177-201. doi: 10.1146/annurev-biochem-052110-120012. Epub 2012 Mar 8. Review.

17.

Letter to the editor. Chemical-genetic strategy for inhibiting proteasome function in Saccharomyces cerevisiae.

Howard GC, Collins GA, Tansey WP.

Yeast. 2012 Feb;29(2):93-4. doi: 10.1002/yea.1919. Epub 2011 Dec 8. No abstract available.

18.

Integrative network analysis identifies key genes and pathways in the progression of hepatitis C virus induced hepatocellular carcinoma.

Zheng S, Tansey WP, Hiebert SW, Zhao Z.

BMC Med Genomics. 2011 Aug 8;4:62. doi: 10.1186/1755-8794-4-62.

19.

Proteolytic control of the oncoprotein transcription factor Myc.

Thomas LR, Tansey WP.

Adv Cancer Res. 2011;110:77-106. doi: 10.1016/B978-0-12-386469-7.00004-9. Review.

PMID:
21704229
20.

Histone H2B ubiquitylation and H3 lysine 4 methylation prevent ectopic silencing of euchromatic loci important for the cellular response to heat.

Leung A, Cajigas I, Jia P, Ezhkova E, Brickner JH, Zhao Z, Geng F, Tansey WP.

Mol Biol Cell. 2011 Aug 1;22(15):2741-53. doi: 10.1091/mbc.E11-05-0426. Epub 2011 Jun 16.

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