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Items: 1 to 20 of 33

1.

The Rhomboid Superfamily: Structural Mechanisms and Chemical Biology Opportunities.

Tichá A, Collis B, Strisovsky K.

Trends Biochem Sci. 2018 Sep;43(9):726-739. doi: 10.1016/j.tibs.2018.06.009. Epub 2018 Jul 25. Review.

PMID:
30055896
2.

iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE.

Oikonomidi I, Burbridge E, Cavadas M, Sullivan G, Collis B, Naegele H, Clancy D, Brezinova J, Hu T, Bileck A, Gerner C, Bolado A, von Kriegsheim A, Martin SJ, Steinberg F, Strisovsky K, Adrain C.

Elife. 2018 Jun 13;7. pii: e35032. doi: 10.7554/eLife.35032.

3.

Benzoxazin-4-ones as novel, easily accessible inhibitors for rhomboid proteases.

Yang J, Barniol-Xicota M, Nguyen MTN, Ticha A, Strisovsky K, Verhelst SHL.

Bioorg Med Chem Lett. 2018 May 1;28(8):1423-1427. doi: 10.1016/j.bmcl.2017.12.056. Epub 2017 Dec 26.

PMID:
29506958
4.

Discovery and validation of 2-styryl substituted benzoxazin-4-ones as a novel scaffold for rhomboid protease inhibitors.

Goel P, Jumpertz T, Tichá A, Ogorek I, Mikles DC, Hubalek M, Pietrzik CU, Strisovsky K, Schmidt B, Weggen S.

Bioorg Med Chem Lett. 2018 May 1;28(8):1417-1422. doi: 10.1016/j.bmcl.2018.02.017. Epub 2018 Feb 9.

PMID:
29463448
5.

Discovery and Biological Evaluation of Potent and Selective N-Methylene Saccharin-Derived Inhibitors for Rhomboid Intramembrane Proteases.

Goel P, Jumpertz T, Mikles DC, Tichá A, Nguyen MTN, Verhelst S, Hubalek M, Johnson DC, Bachovchin DA, Ogorek I, Pietrzik CU, Strisovsky K, Schmidt B, Weggen S.

Biochemistry. 2017 Dec 26;56(51):6713-6725. doi: 10.1021/acs.biochem.7b01066. Epub 2017 Dec 12.

6.

General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases.

Tichá A, Stanchev S, Vinothkumar KR, Mikles DC, Pachl P, Began J, Škerle J, Švehlová K, Nguyen MTN, Verhelst SHL, Johnson DC, Bachovchin DA, Lepšík M, Majer P, Strisovsky K.

Cell Chem Biol. 2017 Dec 21;24(12):1523-1536.e4. doi: 10.1016/j.chembiol.2017.09.007. Epub 2017 Oct 26.

7.

Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis.

Johnson N, Březinová J, Stephens E, Burbridge E, Freeman M, Adrain C, Strisovsky K.

Sci Rep. 2017 Aug 4;7(1):7283. doi: 10.1038/s41598-017-07556-3.

8.

Sensitive Versatile Fluorogenic Transmembrane Peptide Substrates for Rhomboid Intramembrane Proteases.

Tichá A, Stanchev S, Škerle J, Began J, Ingr M, Švehlová K, Polovinkin L, Růžička M, Bednárová L, Hadravová R, Poláchová E, Rampírová P, Březinová J, Kašička V, Majer P, Strisovsky K.

J Biol Chem. 2017 Feb 17;292(7):2703-2713. doi: 10.1074/jbc.M116.762849. Epub 2017 Jan 9.

9.

Activity Assays for Rhomboid Proteases.

Arutyunova E, Strisovsky K, Lemieux MJ.

Methods Enzymol. 2017;584:395-437. doi: 10.1016/bs.mie.2016.11.002. Epub 2016 Dec 8.

PMID:
28065272
10.

Mechanism and Inhibition of Rhomboid Proteases.

Strisovsky K.

Methods Enzymol. 2017;584:279-293. doi: 10.1016/bs.mie.2016.10.014. Epub 2016 Nov 22. Review.

PMID:
28065267
11.

Production of Recombinant Rhomboid Proteases.

Arutyunova E, Panigrahi R, Strisovsky K, Lemieux MJ.

Methods Enzymol. 2017;584:255-278. doi: 10.1016/bs.mie.2016.10.031. Epub 2016 Dec 13.

PMID:
28065266
12.

Rhomboid protease inhibitors: Emerging tools and future therapeutics.

Strisovsky K.

Semin Cell Dev Biol. 2016 Dec;60:52-62. doi: 10.1016/j.semcdb.2016.08.021. Epub 2016 Aug 24. Review.

13.

Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα.

Wunderle L, Knopf JD, Kühnle N, Morlé A, Hehn B, Adrain C, Strisovsky K, Freeman M, Lemberg MK.

Sci Rep. 2016 Jun 6;6:27342. doi: 10.1038/srep27342.

14.

Why cells need intramembrane proteases - a mechanistic perspective.

Strisovsky K.

FEBS J. 2016 May;283(10):1837-45. doi: 10.1111/febs.13638. Epub 2016 Jan 21. Review.

15.

Activity-Based Protein Profiling of Rhomboid Proteases in Liposomes.

Wolf EV, Seybold M, Hadravová R, Strisovsky K, Verhelst SH.

Chembiochem. 2015 Jul 27;16(11):1616-21. doi: 10.1002/cbic.201500213. Epub 2015 Jun 19.

PMID:
26032951
16.

Substrate binding and specificity of rhomboid intramembrane protease revealed by substrate-peptide complex structures.

Zoll S, Stanchev S, Began J, Skerle J, Lepšík M, Peclinovská L, Majer P, Strisovsky K.

EMBO J. 2014 Oct 16;33(20):2408-21. doi: 10.15252/embj.201489367. Epub 2014 Sep 12.

17.

Sharpening rhomboid specificity by dimerisation and allostery.

Strisovsky K, Freeman M.

EMBO J. 2014 Sep 1;33(17):1847-8. doi: 10.15252/embj.201489373. Epub 2014 Jul 15. No abstract available.

18.

Structural and mechanistic principles of intramembrane proteolysis--lessons from rhomboids.

Strisovsky K.

FEBS J. 2013 Apr;280(7):1579-603. doi: 10.1111/febs.12199. Epub 2013 Mar 20. Review.

19.

Mammalian EGF receptor activation by the rhomboid protease RHBDL2.

Adrain C, Strisovsky K, Zettl M, Hu L, Lemberg MK, Freeman M.

EMBO Rep. 2011 May;12(5):421-7. doi: 10.1038/embor.2011.50. Epub 2011 Apr 15.

20.

Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling.

Zettl M, Adrain C, Strisovsky K, Lastun V, Freeman M.

Cell. 2011 Apr 1;145(1):79-91. doi: 10.1016/j.cell.2011.02.047.

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