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TLR4-dependent fibroblast activation drives persistent organ fibrosis in skin and lung.

Bhattacharyya S, Wang W, Qin W, Cheng K, Coulup S, Chavez S, Jiang S, Raparia K, De Almeida LMV, Stehlik C, Tamaki Z, Yin H, Varga J.

JCI Insight. 2018 Jul 12;3(13). pii: 98850. doi: 10.1172/jci.insight.98850.


Lysosomal Cholesterol Hydrolysis Couples Efferocytosis to Anti-Inflammatory Oxysterol Production.

Viaud M, Ivanov S, Vujic N, Duta-Mare M, Aira LE, Barouillet T, Garcia E, Orange F, Dugail I, Hainault I, Stehlik C, Marchetti S, Boyer L, Guinamard R, Foufelle F, Bochem A, Hovingh KG, Thorp EB, Gautier EL, Kratky D, Dasilva-Jardine P, Yvan-Charvet L.

Circ Res. 2018 May 11;122(10):1369-1384. doi: 10.1161/CIRCRESAHA.117.312333. Epub 2018 Mar 9.


The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages.

Chu LH, Indramohan M, Ratsimandresy RA, Gangopadhyay A, Morris EP, Monack DM, Dorfleutner A, Stehlik C.

Nat Commun. 2018 Mar 8;9(1):996. doi: 10.1038/s41467-018-03409-3.


Bim suppresses the development of SLE by limiting myeloid inflammatory responses.

Tsai F, Homan PJ, Agrawal H, Misharin AV, Abdala-Valencia H, Haines GK 3rd, Dominguez S, Bloomfield CL, Saber R, Chang A, Mohan C, Hutcheson J, Davidson A, Budinger GRS, Bouillet P, Dorfleutner A, Stehlik C, Winter DR, Cuda CM, Perlman H.

J Exp Med. 2017 Dec 4;214(12):3753-3773. doi: 10.1084/jem.20170479. Epub 2017 Nov 7.


COPs and POPs Patrol Inflammasome Activation.

Indramohan M, Stehlik C, Dorfleutner A.

J Mol Biol. 2018 Jan 19;430(2):153-173. doi: 10.1016/j.jmb.2017.10.004. Epub 2017 Oct 10. Review.


In vivo Analysis of Neutrophil Infiltration during LPS-induced Peritonitis.

de Almeida L, Dorfleutner A, Stehlik C.

Bio Protoc. 2016 Oct 5;6(19). pii: e1945. doi: 10.21769/BioProtoc.1945.


The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation.

Ratsimandresy RA, Chu LH, Khare S, de Almeida L, Gangopadhyay A, Indramohan M, Misharin AV, Greaves DR, Perlman H, Dorfleutner A, Stehlik C.

Nat Commun. 2017 Jun 5;8:15556. doi: 10.1038/ncomms15556.


ASC-particle-induced Peritonitis.

de Almeida L, Dorfleutner A, Stehlik C.

Bio Protoc. 2016 Oct 5;6(19). pii: e1944. doi: 10.21769/BioProtoc.1944.


SNAPIN is critical for lysosomal acidification and autophagosome maturation in macrophages.

Shi B, Huang QQ, Birkett R, Doyle R, Dorfleutner A, Stehlik C, He C, Pope RM.

Autophagy. 2017 Feb;13(2):285-301. doi: 10.1080/15548627.2016.1261238. Epub 2016 Dec 8.


The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway.

Ratsimandresy RA, Indramohan M, Dorfleutner A, Stehlik C.

Cell Mol Immunol. 2017 Jan;14(1):127-142. doi: 10.1038/cmi.2016.35. Epub 2016 Aug 15.


A dRAStic RHOAdblock of Pyrin inflammasome activation.

Dorfleutner A, Stehlik C.

Nat Immunol. 2016 Jul 19;17(8):900-2. doi: 10.1038/ni.3511. No abstract available.


Measuring NLR Oligomerization I: Size Exclusion Chromatography, Co-immunoprecipitation, and Cross-Linking.

Khare S, Radian AD, Dorfleutner A, Stehlik C.

Methods Mol Biol. 2016;1417:131-43. doi: 10.1007/978-1-4939-3566-6_8.


Conditional deletion of caspase-8 in macrophages alters macrophage activation in a RIPK-dependent manner.

Cuda CM, Misharin AV, Khare S, Saber R, Tsai F, Archer AM, Homan PJ, Haines GK 3rd, Hutcheson J, Dorfleutner A, Budinger GR, Stehlik C, Perlman H.

Arthritis Res Ther. 2015 Oct 16;17:291. doi: 10.1186/s13075-015-0794-z.


The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease.

de Almeida L, Khare S, Misharin AV, Patel R, Ratsimandresy RA, Wallin MC, Perlman H, Greaves DR, Hoffman HM, Dorfleutner A, Stehlik C.

Immunity. 2015 Aug 18;43(2):264-76. doi: 10.1016/j.immuni.2015.07.018. Epub 2015 Aug 11.


ATP binding by NLRP7 is required for inflammasome activation in response to bacterial lipopeptides.

Radian AD, Khare S, Chu LH, Dorfleutner A, Stehlik C.

Mol Immunol. 2015 Oct;67(2 Pt B):294-302. doi: 10.1016/j.molimm.2015.06.013. Epub 2015 Jul 2.


Inhibiting the inflammasome: one domain at a time.

Dorfleutner A, Chu L, Stehlik C.

Immunol Rev. 2015 May;265(1):205-16. doi: 10.1111/imr.12290. Review.


Mechanisms of inflammasome activation by Vibrio cholerae secreted toxins vary with strain biotype.

Queen J, Agarwal S, Dolores JS, Stehlik C, Satchell KJ.

Infect Immun. 2015 Jun;83(6):2496-506. doi: 10.1128/IAI.02461-14. Epub 2015 Apr 6.


T-cell exhaustion in allograft rejection and tolerance.

Thorp EB, Stehlik C, Ansari MJ.

Curr Opin Organ Transplant. 2015 Feb;20(1):37-42. doi: 10.1097/MOT.0000000000000153. Review.


An updated view on the structure and function of PYRIN domains.

Chu LH, Gangopadhyay A, Dorfleutner A, Stehlik C.

Apoptosis. 2015 Feb;20(2):157-73. doi: 10.1007/s10495-014-1065-1.


Caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated dendritic cell activation.

Cuda CM, Misharin AV, Gierut AK, Saber R, Haines GK 3rd, Hutcheson J, Hedrick SM, Mohan C, Budinger GS, Stehlik C, Perlman H.

J Immunol. 2014 Jun 15;192(12):5548-60. doi: 10.4049/jimmunol.1400122. Epub 2014 May 7.

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