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Exp Appl Acarol. 2020 Feb;80(2):257-268. doi: 10.1007/s10493-019-00458-1. Epub 2020 Jan 2.

Field evaluation of a novel oral reservoir-targeted vaccine against Borrelia burgdorferi utilizing an inactivated whole-cell bacterial antigen expression vehicle.

Author information

1
Center for Vector Biology & Zoonotic Diseases, The Connecticut Agricultural Experiment Station, 123 Huntington Street, New Haven, CT, 06511, USA.
2
Center for Vector Biology & Zoonotic Diseases, The Connecticut Agricultural Experiment Station, 123 Huntington Street, New Haven, CT, 06511, USA. scott.williams@ct.gov.
3
U.S. Biologic, Inc., Memphis, TN, USA.
4
Department of Epidemiology of Microbial Diseases, School of Public Health, Yale University, New Haven, CT, USA.
5
Department of Medical Sciences, School of Medicine, Quinnipiac University, Hamden, CT, USA.

Abstract

Blacklegged ticks (Ixodes scapularis) are the principal vector for Borrelia burgdorferi, among other infectious agents, in the northeastern, mid-Atlantic, and upper midwestern USA. White-footed mice (Peromyscus leucopus) are the primary and most competent reservoir host of B. burgdorferi in the Northeast. Live reservoir-targeted vaccines (RTVs) to limit enzootic transmission of B. burgdorferi were previously developed and successfully evaluated in laboratory and controlled field trials. A novel, inactivated RTV was developed to minimize regulatory and market challenges facing previous RTVs based on live bacterial or viral vehicles. Thirty-two residential properties in Redding, Connecticut, participated in a field trial of an orally delivered, inactivated RTV efficacy study (2015-2016). During the two-year vaccination period, a significant decrease in the percentage of B. burgdorferi-infected I. scapularis larvae parasitizing P. leucopus was observed, as was a significant reduction in the percentage of infected P. leucopus on RTV-treated properties when compared to control properties. This novel inactivated RTV was effective in reducing numbers of B. burgdorferi-infected I. scapularis and B. burgdorferi-infected P. leucopus on properties where it was distributed.

KEYWORDS:

Borrelia burgdorferi; Inactivated expression vehicle; Ixodes scapularis; Peromyscus leucopus; Reservoir-targeted vaccine

PMID:
31898760
DOI:
10.1007/s10493-019-00458-1

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