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Items: 1 to 20 of 199

1.

Hypoglycemic and Hypolipemic effects of a new lecithin formulation of Bergamot Polyphenolic Fraction: a double blind, randomized, placebo-controlled study.

Mollace V, Scicchitano M, Paone S, Casale F, Calandruccio C, Gliozzi M, Musolino V, Carresi C, Maiuolo J, Nucera S, Riva A, Allegrini P, Ronchi M, Petrangolini G, Bombardelli E.

Endocr Metab Immune Disord Drug Targets. 2018 Dec 3. doi: 10.2174/1871530319666181203151513. [Epub ahead of print]

PMID:
30501605
2.

Pharmacokinetics, tissue distribution and excretion of ACT001 in Sprague-Dawley rats and metabolism of ACT001.

Xi XN, Liu N, Wang QQ, Wu HT, He HB, Wang LL, Zhang TJ, Sun L, Yin Z, Chen Y, Lu YX.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Nov 6;1104:29-39. doi: 10.1016/j.jchromb.2018.11.004. [Epub ahead of print]

PMID:
30423524
3.

Characterization of Casearin X Metabolism by Rat and Human Liver Microsomes.

Moreira da Silva R, de Gaitani CM, Marques LMM, Fraige Baraco K, Cavalheiro AJ, de Moraes LAB, Lopes NP, de Oliveira ARM.

Planta Med. 2018 Oct 29. doi: 10.1055/a-0765-9523. [Epub ahead of print]

PMID:
30372780
4.

Bioavailability and Safety of Nutrients from the Microalgae Chlorella vulgaris, Nannochloropsis oceanica and Phaeodactylum tricornutum in C57BL/6 Mice.

Neumann U, Derwenskus F, Gille A, Louis S, Schmid-Staiger U, Briviba K, Bischoff SC.

Nutrients. 2018 Jul 26;10(8). pii: E965. doi: 10.3390/nu10080965.

5.

In vitrometabolic mapping of neobavaisoflavone in human cytochromes P450 and UDP-glucuronosyltransferase enzymes by ultra high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry.

Xu J, Li M, Yao Z, Zhang Y, Li S, Hu L, Qin Z, Gonzalez FJ, Yao X.

J Pharm Biomed Anal. 2018 Sep 5;158:351-360. doi: 10.1016/j.jpba.2018.06.022. Epub 2018 Jun 18.

PMID:
29933228
6.

Evaluation of Marbofloxacin in Beagle Dogs After Oral Dosing: Preclinical Safety Evaluation and Comparative Pharmacokinetics of Two Different Tablets.

Lei Z, Liu Q, Yang B, Khaliq H, Ahmed S, Fan B, Cao J, He Q.

Front Pharmacol. 2018 Apr 10;9:306. doi: 10.3389/fphar.2018.00306. eCollection 2018. Erratum in: Front Pharmacol. 2018 Nov 28;9:1385.

7.

The pig as a preclinical model for predicting oral bioavailability and in vivo performance of pharmaceutical oral dosage forms: a PEARRL review.

Henze LJ, Koehl NJ, O'Shea JP, Kostewicz ES, Holm R, Griffin BT.

J Pharm Pharmacol. 2018 Apr 10. doi: 10.1111/jphp.12912. [Epub ahead of print] Review.

PMID:
29635685
8.

Differences in nonclinical pharmacokinetics between species and prediction of human pharmacokinetics of TAK-272 (SCO-272), a novel orally active renin inhibitor.

Ebihara T, Nishihara M, Takahashi J, Jinno F, Tagawa Y.

Biopharm Drug Dispos. 2018 Mar;39(3):175-183. doi: 10.1002/bdd.2124.

PMID:
29474740
9.

Comparative Toxicokinetics and Plasma Protein Binding of Ochratoxin A in Four Avian Species.

Devreese M, Croubels S, De Baere S, Gehring R, Antonissen G.

J Agric Food Chem. 2018 Mar 7;66(9):2129-2135. doi: 10.1021/acs.jafc.7b06048. Epub 2018 Feb 20.

PMID:
29417821
10.

Pharmacokinetics of the anticonvulsant levetiracetam in neonatal foals.

MacDonald KD, Hart KA, Davis JL, Berghaus LJ, Giguère S.

Equine Vet J. 2018 Jul;50(4):532-536. doi: 10.1111/evj.12790. Epub 2017 Dec 30.

PMID:
29194744
11.

Disposition of [14C]hydroquinone in Harlan Sprague-Dawley rats and B6C3F1/N mice: species and route comparison.

Black SR, Fennell TR, Mathews JM, Snyder RW, Patel PR, Watson SL, Sutherland V, Waidyanatha S.

Xenobiotica. 2018 Nov;48(11):1128-1141. doi: 10.1080/00498254.2017.1398847. Epub 2017 Nov 22.

PMID:
29166815
12.

Differences of first-pass effect in the liver and intestine contribute to the stereoselective pharmacokinetics of rhynchophylline and isorhynchophylline epimers in rats.

Wang X, Zheng M, Liu J, Huang Z, Bai Y, Ren Z, Wang Z, Tian Y, Qiao Z, Liu W, Feng F.

J Ethnopharmacol. 2017 Sep 14;209:175-183. doi: 10.1016/j.jep.2017.07.039. Epub 2017 Jul 26.

PMID:
28755970
13.

Pharmacokinetics and Relative Bioavailability of Orally Administered Innovator-Formulated Itraconazole Capsules and Solution in Healthy Dogs.

Hasbach AE, Langlois DK, Rosser EJ Jr, Papich MG.

J Vet Intern Med. 2017 Jul;31(4):1163-1169. doi: 10.1111/jvim.14779. Epub 2017 Jun 19.

14.

Exploring Canine-Human Differences in Product Performance. Part II: Use of Modeling and Simulation to Explore the Impact of Formulation on Ciprofloxacin In Vivo Absorption and Dissolution in Dogs.

Martinez MN, Mistry B, Lukacova V, Lentz KA, Polli JE, Hoag SW, Dowling T, Kona R, Fahmy RM.

AAPS J. 2017 May;19(3):712-726. doi: 10.1208/s12248-017-0055-y. Epub 2017 Mar 6.

PMID:
28265981
15.

Biopharmaceutical Characterization and Bioavailability Study of a Tetrazole Analog of Clofibric Acid in Rat.

Vara-Gama N, Valladares-Méndez A, Navarrete-Vazquez G, Estrada-Soto S, Orozco-Castellanos LM, Rivera-Leyva JC.

Molecules. 2017 Feb 14;22(2). pii: E282. doi: 10.3390/molecules22020282.

16.

Comparative pharmacokinetics of diaveridine in pigs and chickens following single intravenous and oral administration.

Li YF, Guo HY, Yang F, Zhou LG, Huang XH, Ding HZ, Zeng ZL.

J Vet Pharmacol Ther. 2017 Oct;40(5):500-504. doi: 10.1111/jvp.12384. Epub 2017 Jan 17.

PMID:
28093774
17.

Establishment of a cell line for assessing drugs as canine P-glycoprotein substrates: proof of principle.

Mealey KL, Dassanayake S, Burke NS.

J Vet Pharmacol Ther. 2017 Oct;40(5):545-551. doi: 10.1111/jvp.12390. Epub 2017 Jan 17.

PMID:
28093773
18.

Beetroot juice versus chard gel: A pharmacokinetic and pharmacodynamic comparison of nitrate bioavailability.

McIlvenna LC, Monaghan C, Liddle L, Fernandez BO, Feelisch M, Muggeridge DJ, Easton C.

Nitric Oxide. 2017 Apr 1;64:61-67. doi: 10.1016/j.niox.2016.12.006. Epub 2016 Dec 29.

PMID:
28042082
19.

A molecular dynamics study of the BACE1 conformational change from Apo to closed form induced by hydroxyethylamine derived compounds.

Gueto-Tettay C, Zuchniarz J, Fortich-Seca Y, Gueto-Tettay LR, Drosos-Ramirez JC.

J Mol Graph Model. 2016 Nov;70:181-195. doi: 10.1016/j.jmgm.2016.10.006. Epub 2016 Oct 7.

PMID:
27750187
20.

Discovery of novel 2',4'-dimethyl-[4,5'-bithiazol]-2-yl amino derivatives as orally bioavailable TRPV4 antagonists for the treatment of pain: Part 2.

Tsuno N, Yukimasa A, Yoshida O, Suzuki S, Nakai H, Ogawa T, Fujiu M, Takaya K, Nozu A, Yamaguchi H, Matsuda H, Funaki S, Nishimura Y, Ito T, Nagamatsu D, Asaki T, Horita N, Yamamoto M, Hinata M, Soga M, Imai M, Morioka Y, Kanemasa T, Sakaguchi G, Iso Y.

Bioorg Med Chem Lett. 2016 Oct 15;26(20):4936-4941. doi: 10.1016/j.bmcl.2016.09.014. Epub 2016 Sep 7.

PMID:
27634196

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