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Items: 15

1.

Structural Basis for Signaling Through Shared Common γ Chain Cytokines.

Yang H, Kureshi R, Spangler JB.

Adv Exp Med Biol. 2019;1172:1-19. doi: 10.1007/978-981-13-9367-9_1. Review.

PMID:
31628649
2.

A strategy for the selection of monovalent antibodies that span protein dimer interfaces.

Spangler JB, Moraga I, Jude KM, Savvides CS, Garcia KC.

J Biol Chem. 2019 Sep 20;294(38):13876-13886. doi: 10.1074/jbc.RA119.009213. Epub 2019 Aug 6.

3.

Weaponizing T-cell receptors through molecular engineering.

Leonard EK, Leff MI, Spangler JB.

J Biol Chem. 2019 Apr 12;294(15):5805-5806. doi: 10.1074/jbc.H119.008479.

4.

Emerging technologies in protein interface engineering for biomedical applications.

Krohl PJ, Ludwig SD, Spangler JB.

Curr Opin Biotechnol. 2019 Feb 22;60:82-88. doi: 10.1016/j.copbio.2019.01.017. [Epub ahead of print] Review.

PMID:
30802788
5.

De novo design of potent and selective mimics of IL-2 and IL-15.

Silva DA, Yu S, Ulge UY, Spangler JB, Jude KM, Labão-Almeida C, Ali LR, Quijano-Rubio A, Ruterbusch M, Leung I, Biary T, Crowley SJ, Marcos E, Walkey CD, Weitzner BD, Pardo-Avila F, Castellanos J, Carter L, Stewart L, Riddell SR, Pepper M, Bernardes GJL, Dougan M, Garcia KC, Baker D.

Nature. 2019 Jan;565(7738):186-191. doi: 10.1038/s41586-018-0830-7. Epub 2019 Jan 9.

6.

Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy.

Spangler JB, Trotta E, Tomala J, Peck A, Young TA, Savvides CS, Silveria S, Votavova P, Salafsky J, Pande VS, Kovar M, Bluestone JA, Garcia KC.

J Immunol. 2018 Oct 1;201(7):2094-2106. doi: 10.4049/jimmunol.1800578. Epub 2018 Aug 13.

7.

Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers.

Moraga I, Spangler JB, Mendoza JL, Gakovic M, Wehrman TS, Krutzik P, Garcia KC.

Elife. 2017 May 12;6. pii: e22882. doi: 10.7554/eLife.22882.

8.

Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps.

Mitra S, Ring AM, Amarnath S, Spangler JB, Li P, Ju W, Fischer S, Oh J, Spolski R, Weiskopf K, Kohrt H, Foley JE, Rajagopalan S, Long EO, Fowler DH, Waldmann TA, Garcia KC, Leonard WJ.

Immunity. 2015 May 19;42(5):826-38. doi: 10.1016/j.immuni.2015.04.018.

9.

Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms.

Spangler JB, Tomala J, Luca VC, Jude KM, Dong S, Ring AM, Votavova P, Pepper M, Kovar M, Garcia KC.

Immunity. 2015 May 19;42(5):815-25. doi: 10.1016/j.immuni.2015.04.015.

10.

Insights into cytokine-receptor interactions from cytokine engineering.

Spangler JB, Moraga I, Mendoza JL, Garcia KC.

Annu Rev Immunol. 2015;33:139-67. doi: 10.1146/annurev-immunol-032713-120211. Epub 2014 Dec 10. Review.

11.

Multifarious determinants of cytokine receptor signaling specificity.

Moraga I, Spangler J, Mendoza JL, Garcia KC.

Adv Immunol. 2014;121:1-39. doi: 10.1016/B978-0-12-800100-4.00001-5. Review.

12.

Triepitopic antibody fusions inhibit cetuximab-resistant BRAF and KRAS mutant tumors via EGFR signal repression.

Spangler JB, Manzari MT, Rosalia EK, Chen TF, Wittrup KD.

J Mol Biol. 2012 Sep 28;422(4):532-44. doi: 10.1016/j.jmb.2012.06.014. Epub 2012 Jun 15.

13.

Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling.

Spangler JB, Neil JR, Abramovitch S, Yarden Y, White FM, Lauffenburger DA, Wittrup KD.

Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13252-7. doi: 10.1073/pnas.0913476107. Epub 2010 Jul 7.

14.

Effect of pathogenic cysteine mutations on FGFR3 transmembrane domain dimerization in detergents and lipid bilayers.

You M, Spangler J, Li E, Han X, Ghosh P, Hristova K.

Biochemistry. 2007 Oct 2;46(39):11039-46. Epub 2007 Sep 11.

PMID:
17845056
15.

Synthesis and initial characterization of FGFR3 transmembrane domain: consequences of sequence modifications.

Iwamoto T, You M, Li E, Spangler J, Tomich JM, Hristova K.

Biochim Biophys Acta. 2005 Mar 1;1668(2):240-7. Epub 2005 Jan 28.

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