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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2007 5
2008 1
2009 5
2010 9
2011 10
2012 16
2013 7
2014 12
2015 6
2016 5
2017 5
2018 13
2019 16
2020 10
2021 13
2022 9
2023 7
2024 2

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127 results

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Page 1
Cytomodulin-10 modified GelMA hydrogel with kartogenin for in-situ osteochondral regeneration.
Liu G, Guo Q, Liu C, Bai J, Wang H, Li J, Liu D, Yu Q, Shi J, Liu C, Zhu C, Li B, Zhang H. Liu G, et al. Acta Biomater. 2023 Oct 1;169:317-333. doi: 10.1016/j.actbio.2023.08.013. Epub 2023 Aug 15. Acta Biomater. 2023. PMID: 37586447
Moreover, it was revealed that CM-10 and KGN had a synergistic effect on promoting the chondrogenesis of BMSCs by up-regulating the expression of RUNX1 and SOX9 at both mRNA and protein levels in vitro. Finally, the composite hydrogel exhibited a satisfactory osteochond …
Moreover, it was revealed that CM-10 and KGN had a synergistic effect on promoting the chondrogenesis of BMSCs by up-regulating the expressi …
rAAV-Mediated sox9 Overexpression Improves the Repair of Osteochondral Defects in a Clinically Relevant Large Animal Model Over Time In Vivo and Reduces Perifocal Osteoarthritic Changes.
Lange C, Madry H, Venkatesan JK, Schmitt G, Speicher-Mentges S, Zurakowski D, Menger MD, Laschke MW, Cucchiarini M. Lange C, et al. Am J Sports Med. 2021 Nov;49(13):3696-3707. doi: 10.1177/03635465211049414. Epub 2021 Oct 13. Am J Sports Med. 2021. PMID: 34643471
PURPOSE: To examine the ability of an rAAV sox9 construct to improve the repair of focal osteochondral defects and oppose perifocal OA development over time in a large translational model relative to control gene transfer. ...CONCLUSION: rAAV-mediated sox9 ge …
PURPOSE: To examine the ability of an rAAV sox9 construct to improve the repair of focal osteochondral defects and oppose peri …
Direct rAAV SOX9 administration for durable articular cartilage repair with delayed terminal differentiation and hypertrophy in vivo.
Cucchiarini M, Orth P, Madry H. Cucchiarini M, et al. J Mol Med (Berl). 2013 May;91(5):625-36. doi: 10.1007/s00109-012-0978-9. Epub 2012 Nov 13. J Mol Med (Berl). 2013. PMID: 23149825
Here, we tested the ability of a recombinant adeno-associated virus (rAAV) SOX9 vector to enhance the repair of cartilage lesions in vivo. The candidate construct was provided to osteochondral defects in rabbit knee joints vis-a-vis control (lacZ) vector treatment a …
Here, we tested the ability of a recombinant adeno-associated virus (rAAV) SOX9 vector to enhance the repair of cartilage lesions in …
Enhanced chondrogenesis from human embryonic stem cells.
Wang T, Nimkingratana P, Smith CA, Cheng A, Hardingham TE, Kimber SJ. Wang T, et al. Stem Cell Res. 2019 Aug;39:101497. doi: 10.1016/j.scr.2019.101497. Epub 2019 Jul 9. Stem Cell Res. 2019. PMID: 31326745 Free PMC article.
However, replacing BMP4 with BMP2 (days 3-10 of the protocol) resulted in a more rapid increase in SOX9 gene expression and increased expression of chondrogenic genes SOX5, ACAN and COL2A1. ...The results demonstrate that BMP2 has greater specificity for the generation of …
However, replacing BMP4 with BMP2 (days 3-10 of the protocol) resulted in a more rapid increase in SOX9 gene expression and increased …
Effective Remodelling of Human Osteoarthritic Cartilage by sox9 Gene Transfer and Overexpression upon Delivery of rAAV Vectors in Polymeric Micelles.
Rey-Rico A, Venkatesan JK, Schmitt G, Speicher-Mentges S, Madry H, Cucchiarini M. Rey-Rico A, et al. Mol Pharm. 2018 Jul 2;15(7):2816-2826. doi: 10.1021/acs.molpharmaceut.8b00331. Epub 2018 May 24. Mol Pharm. 2018. PMID: 29763553
In the present study, we examined the convenience of delivering rAAV vectors via poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) polymeric (PEO-PPO-PEO) micelles to transfer and overexpress the transcription factor SOX9 in monolayers of human OA chondrocytes and …
In the present study, we examined the convenience of delivering rAAV vectors via poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) …
Continuous Low-Intensity Ultrasound Promotes Native-to-Native Cartilage Integration.
Sahu N, Miller A, Viljoen HJ, Subramanian A. Sahu N, et al. Tissue Eng Part A. 2019 Nov;25(21-22):1538-1549. doi: 10.1089/ten.TEA.2018.0355. Epub 2019 Oct 25. Tissue Eng Part A. 2019. PMID: 31190618
Cylindrical incisions (4 mm) simulating chondral discontinuity were made in bovine cartilage and osteochondral explants, and maintained under cLIUS stimulation (14 kPa [5 MHz, 2.5 Vpp], 20 min, four times/day) for 28 days. ...As a separate study group, incised osteochon …
Cylindrical incisions (4 mm) simulating chondral discontinuity were made in bovine cartilage and osteochondral explants, and maintain …
Suppressing PLCγ1 enhances osteogenic and chondrogenic potential of BMSCs.
Chen X, Wang Y, Chen R, Qu N, Zhang B, Xia C. Chen X, et al. Biochem Biophys Res Commun. 2020 Nov 5;532(2):292-299. doi: 10.1016/j.bbrc.2020.08.049. Epub 2020 Aug 29. Biochem Biophys Res Commun. 2020. PMID: 32868075 Free article.
The results of qPCR technique and Western blot analysis showed that long-term treatment of U73122 enhanced COL1A1 and OPG mRNA levels and Collagen 1A1, BMP2, and p-Smad1/5/9 protein levels and that short-term treatment of U73122 enhanced COL2A1 and SOX9 mRNA levels and Col …
The results of qPCR technique and Western blot analysis showed that long-term treatment of U73122 enhanced COL1A1 and OPG mRNA levels and Co …
Role of cartilage and bone matrix regulation in early equine osteochondrosis.
Grissom SK, Semevolos SA, Duesterdieck-Zellmer K. Grissom SK, et al. Bone Rep. 2023 Jan 5;18:101653. doi: 10.1016/j.bonr.2023.101653. eCollection 2023 Jun. Bone Rep. 2023. PMID: 36632355 Free PMC article.
Paraffin-embedded osteochondral samples (6 OC-affected, 8 normal controls) and cDNA from chondrocytes captured with laser capture microdissection from frozen sections (4 OC-affected, 5 normal controls) were used in this study. Quantitative real-time polymerase chain reacti …
Paraffin-embedded osteochondral samples (6 OC-affected, 8 normal controls) and cDNA from chondrocytes captured with laser capture mic …
127 results