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Items: 1 to 20 of 317

1.

Cytochrome b5 enhances androgen synthesis by rapidly reducing the CYP17A1 oxy-complex in the lyase step.

Duggal R, Denisov IG, Sligar SG.

FEBS Lett. 2018 Jul;592(13):2282-2288. doi: 10.1002/1873-3468.13153. Epub 2018 Jun 21.

PMID:
29888793
2.

Human Cytochrome CYP17A1: The Structural Basis for Compromised Lyase Activity with 17-Hydroxyprogesterone.

Mak PJ, Duggal R, Denisov IG, Gregory MC, Sligar SG, Kincaid JR.

J Am Chem Soc. 2018 Jun 13;140(23):7324-7331. doi: 10.1021/jacs.8b03901. Epub 2018 Jun 5.

PMID:
29758981
3.

Nanodiscs: A Controlled Bilayer Surface for the Study of Membrane Proteins.

McLean MA, Gregory MC, Sligar SG.

Annu Rev Biophys. 2018 Mar 1. doi: 10.1146/annurev-biophys-070816-033620. [Epub ahead of print]

PMID:
29494254
4.

Human P450 CYP17A1: Control of Substrate Preference by Asparagine 202.

Gregory MC, Mak PJ, Khatri Y, Kincaid JR, Sligar SG.

Biochemistry. 2018 Feb 6;57(5):764-771. doi: 10.1021/acs.biochem.7b01067. Epub 2018 Jan 24.

PMID:
29283561
5.

Drug-Drug Interactions between Atorvastatin and Dronedarone Mediated by Monomeric CYP3A4.

Denisov IG, Baylon JL, Grinkova YV, Tajkhorshid E, Sligar SG.

Biochemistry. 2018 Feb 6;57(5):805-816. doi: 10.1021/acs.biochem.7b01012. Epub 2017 Dec 14.

6.

Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria.

Guo Z, Sevrioukova IF, Denisov IG, Zhang X, Chiu TL, Thomas DG, Hanse EA, Cuellar RAD, Grinkova YV, Langenfeld VW, Swedien DS, Stamschror JD, Alvarez J, Luna F, Galván A, Bae YK, Wulfkuhle JD, Gallagher RI, Petricoin EF Rd, Norris B, Flory CM, Schumacher RJ, O'Sullivan MG, Cao Q, Chu H, Lipscomb JD, Atkins WM, Gupta K, Kelekar A, Blair IA, Capdevila JH, Falck JR, Sligar SG, Poulos TL, Georg GI, Ambrose E, Potter DA.

Cell Chem Biol. 2017 Oct 19;24(10):1314. doi: 10.1016/j.chembiol.2017.09.012. No abstract available.

PMID:
29053951
7.

Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria.

Guo Z, Sevrioukova IF, Denisov IG, Zhang X, Chiu TL, Thomas DG, Hanse EA, Cuellar RAD, Grinkova YV, Langenfeld VW, Swedien DS, Stamschror JD, Alvarez J, Luna F, Galván A, Bae YK, Wulfkuhle JD, Gallagher RI, Petricoin EF Rd, Norris B, Flory CM, Schumacher RJ, O'Sullivan MG, Cao Q, Chu H, Lipscomb JD, Atkins WM, Gupta K, Kelekar A, Blair IA, Capdevila JH, Falck JR, Sligar SG, Poulos TL, Georg GI, Ambrose E, Potter DA.

Cell Chem Biol. 2017 Oct 19;24(10):1259-1275.e6. doi: 10.1016/j.chembiol.2017.08.009. Epub 2017 Sep 14.

8.

Microfluidic platform for efficient Nanodisc assembly, membrane protein incorporation, and purification.

Wade JH, Jones JD, Lenov IL, Riordan CM, Sligar SG, Bailey RC.

Lab Chip. 2017 Aug 22;17(17):2951-2959. doi: 10.1039/c7lc00601b.

9.

Interaction of KRas4b with anionic membranes: A special role for PIP2.

Gregory MC, McLean MA, Sligar SG.

Biochem Biophys Res Commun. 2017 May 27;487(2):351-355. doi: 10.1016/j.bbrc.2017.04.063. Epub 2017 Apr 13.

10.

Conformational equilibria of light-activated rhodopsin in nanodiscs.

Van Eps N, Caro LN, Morizumi T, Kusnetzow AK, Szczepek M, Hofmann KP, Bayburt TH, Sligar SG, Ernst OP, Hubbell WL.

Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3268-E3275. doi: 10.1073/pnas.1620405114. Epub 2017 Apr 3.

11.

Alzheimer's Toxic Amyloid Beta Oligomers: Unwelcome Visitors to the Na/K ATPase alpha3 Docking Station.

DiChiara T, DiNunno N, Clark J, Bu RL, Cline EN, Rollins MG, Gong Y, Brody DL, Sligar SG, Velasco PT, Viola KL, Klein WL.

Yale J Biol Med. 2017 Mar 29;90(1):45-61. eCollection 2017 Mar.

12.

Nanodiscs in Membrane Biochemistry and Biophysics.

Denisov IG, Sligar SG.

Chem Rev. 2017 Mar 22;117(6):4669-4713. doi: 10.1021/acs.chemrev.6b00690. Epub 2017 Feb 8. Review.

13.

The Charge Properties of Phospholipid Nanodiscs.

Her C, Filoti DI, McLean MA, Sligar SG, Alexander Ross JB, Steele H, Laue TM.

Biophys J. 2016 Sep 6;111(5):989-98. doi: 10.1016/j.bpj.2016.06.041.

14.

Phosphatidylinositol 4,5-Bisphosphate Modulates the Affinity of Talin-1 for Phospholipid Bilayers and Activates Its Autoinhibited Form.

Ye X, McLean MA, Sligar SG.

Biochemistry. 2016 Sep 13;55(36):5038-48. doi: 10.1021/acs.biochem.6b00497. Epub 2016 Aug 31.

15.

Evidence that cytochrome b5 acts as a redox donor in CYP17A1 mediated androgen synthesis.

Duggal R, Liu Y, Gregory MC, Denisov IG, Kincaid JR, Sligar SG.

Biochem Biophys Res Commun. 2016 Aug 19;477(2):202-8. doi: 10.1016/j.bbrc.2016.06.043. Epub 2016 Jun 10.

16.

Nanodiscs for structural and functional studies of membrane proteins.

Denisov IG, Sligar SG.

Nat Struct Mol Biol. 2016 Jun;23(6):481-6. doi: 10.1038/nsmb.3195. Epub 2016 Jun 7. Review.

PMID:
27273631
17.

Conformational equilibrium of talin is regulated by anionic lipids.

Ye X, McLean MA, Sligar SG.

Biochim Biophys Acta. 2016 Aug;1858(8):1833-40. doi: 10.1016/j.bbamem.2016.05.005. Epub 2016 May 6.

18.

Trimerization of the HIV Transmembrane Domain in Lipid Bilayers Modulates Broadly Neutralizing Antibody Binding.

Reichart TM, Baksh MM, Rhee JK, Fiedler JD, Sligar SG, Finn MG, Zwick MB, Dawson PE.

Angew Chem Int Ed Engl. 2016 Feb 18;55(8):2688-92. doi: 10.1002/anie.201508421. Epub 2016 Jan 22.

19.

The use of isomeric testosterone dimers to explore allosteric effects in substrate binding to cytochrome P450 CYP3A4.

Denisov IG, Mak PJ, Grinkova YV, Bastien D, Bérubé G, Sligar SG, Kincaid JR.

J Inorg Biochem. 2016 May;158:77-85. doi: 10.1016/j.jinorgbio.2015.12.019. Epub 2015 Dec 31.

20.

Unveiling the crucial intermediates in androgen production.

Mak PJ, Gregory MC, Denisov IG, Sligar SG, Kincaid JR.

Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15856-61. doi: 10.1073/pnas.1519376113. Epub 2015 Dec 14.

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