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Curr Treat Options Neurol. 2018 Sep 27;20(11):46. doi: 10.1007/s11940-018-0531-4.

Sleep Abnormalities in Wilson's Disease.

Author information

1
Sleep Unit, Beau Soleil Clinic, 119 Avenue de Lodève, 34070, Montpellier, France. valerie.cochen@gmail.com.
2
EuroMov, Montpellier University, 700 Avenue du Pic Saint Loup, 34090, Montpellier, France. valerie.cochen@gmail.com.
3
French National Reference Centre for Wilson's Disease, University Hospital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France.
4
Department of Neurology, University Hospital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France.

Abstract

PURPOSE OF REVIEW:

The aim of this article was to review the different sleep disorders associated with Wilson's disease (WD), their mechanisms and their treatments.

RECENT FINDINGS:

Some of these disorders such as REM sleep behavior disorder or sleepiness can appear as a prodromal phase phenomenon in WD allowing an early treatment of the disease and sometimes a resolution of the sleep disorder. Sleep disorders in WD are frequent combining insomnia, daytime sleepiness, restless legs syndrome (RLS), cataplexy-like episodes, and REM sleep behavior disorder (RBD). Sleep recordings confirm these disorders. Mechanisms involved in these disorders are complex associating (a) lesions of the pathways regulating sleep and wake or mood but also controlling movement, (b) iatrogenic effects of the treatments, and (3) consequences of the motor or dysautonomic or metabolic disorders.

KEYWORDS:

Cataplexy-like episodes; Insomnia; Periodic limb movements; REM sleep behavior disorder; Restless legs syndrome; Sleepiness; Wilson’s disease

PMID:
30259205
DOI:
10.1007/s11940-018-0531-4

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