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Items: 1 to 20 of 72


MN1 is indispensable for MLL-rearranged acute myeloid leukemia.

Sharma A, Jyotsana N, Gabdoulline R, Heckl D, Kuchenbauer F, Slany RK, Ganser A, Heuser M.

Haematologica. 2019 Aug 14. pii: haematol.2018.211201. doi: 10.3324/haematol.2018.211201. [Epub ahead of print]


HoxA9 transforms murine myeloid cells by a feedback loop driving expression of key oncogenes and cell cycle control genes.

Zhong X, Prinz A, Steger J, Garcia-Cuellar MP, Radsak M, Bentaher A, Slany RK.

Blood Adv. 2018 Nov 27;2(22):3137-3148. doi: 10.1182/bloodadvances.2018025866.


The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice.

Schmidt K, Zhang Q, Tasdogan A, Petzold A, Dahl A, Arneth BM, Slany R, Fehling HJ, Kranz A, Stewart AF, Anastassiadis K.

Elife. 2018 Jun 19;7. pii: e27157. doi: 10.7554/eLife.27157.


Five percent of healthy newborns have an ETV6-RUNX1 fusion as revealed by DNA-based GIPFEL screening.

Schäfer D, Olsen M, Lähnemann D, Stanulla M, Slany R, Schmiegelow K, Borkhardt A, Fischer U.

Blood. 2018 Feb 15;131(7):821-826. doi: 10.1182/blood-2017-09-808402. Epub 2018 Jan 8. No abstract available.


The interaction of ENL with PAF1 mitigates polycomb silencing and facilitates murine leukemogenesis.

Hetzner K, Garcia-Cuellar MP, Büttner C, Slany RK.

Blood. 2018 Feb 8;131(6):662-673. doi: 10.1182/blood-2017-11-815035. Epub 2017 Dec 7.


AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia.

Zhou F, Liu Y, Rohde C, Pauli C, Gerloff D, Köhn M, Misiak D, Bäumer N, Cui C, Göllner S, Oellerich T, Serve H, Garcia-Cuellar MP, Slany R, Maciejewski JP, Przychodzen B, Seliger B, Klein HU, Bartenhagen C, Berdel WE, Dugas M, Taketo MM, Farouq D, Schwartz S, Regev A, Hébert J, Sauvageau G, Pabst C, Hüttelmaier S, Müller-Tidow C.

Nat Cell Biol. 2017 Jul;19(7):844-855. doi: 10.1038/ncb3563. Epub 2017 Jun 26.


Protein kinase Msk1 physically and functionally interacts with the KMT2A/MLL1 methyltransferase complex and contributes to the regulation of multiple target genes.

Wiersma M, Bussiere M, Halsall JA, Turan N, Slany R, Turner BM, Nightingale KP.

Epigenetics Chromatin. 2016 Nov 11;9:52. eCollection 2016.


Leukemogenic MLL-ENL Fusions Induce Alternative Chromatin States to Drive a Functionally Dichotomous Group of Target Genes.

Garcia-Cuellar MP, Büttner C, Bartenhagen C, Dugas M, Slany RK.

Cell Rep. 2016 Apr 12;15(2):310-22. doi: 10.1016/j.celrep.2016.03.018. Epub 2016 Mar 31.


The molecular mechanics of mixed lineage leukemia.

Slany RK.

Oncogene. 2016 Oct 6;35(40):5215-5223. doi: 10.1038/onc.2016.30. Epub 2016 Feb 29. Review.


The New Semisynthetic Cardenolide Analog 3β-[2-(1-Amantadine)-1-on-ethylamine]-digitoxigenin (AMANTADIG) Efficiently Suppresses Cell Growth in Human Leukemia and Urological Tumor Cell Lines.

Nolte E, Sobel A, Wach S, Hertlein H, Ebert N, Müller-Uri F, Slany R, Taubert H, Wullich B, Kreis W.

Anticancer Res. 2015 Oct;35(10):5271-5.


From initiation to eradication: the lifespan of an MLL-rearranged therapy-related paediatric AML.

Krumbholz M, Bradtke J, Stachel D, Peters O, Hero B, Holter W, Slany R, Metzler M.

Bone Marrow Transplant. 2015 Oct;50(10):1382-4. doi: 10.1038/bmt.2015.155. Epub 2015 Jul 6. No abstract available.


Retrovirus-Mediated Expression of E2A-PBX1 Blocks Lymphoid Fate but Permits Retention of Myeloid Potential in Early Hematopoietic Progenitors.

Woodcroft MW, Nanan K, Thompson P, Tyryshkin K, Smith SP, Slany RK, LeBrun DP.

PLoS One. 2015 Jun 22;10(6):e0130495. doi: 10.1371/journal.pone.0130495. eCollection 2015.


Pbx3 and Meis1 cooperate through multiple mechanisms to support Hox-induced murine leukemia.

Garcia-Cuellar MP, Steger J, Füller E, Hetzner K, Slany RK.

Haematologica. 2015 Jul;100(7):905-13. doi: 10.3324/haematol.2015.124032. Epub 2015 Apr 24.


DOTting the path to doom: how acceleration of histone methylation leads to leukemia.

Bach C, Slany RK.

Cancer Cell. 2014 Dec 8;26(6):781-782. doi: 10.1016/j.ccell.2014.11.004.


Up-regulated MSI2 is associated with more aggressive chronic myeloid leukemia.

Kaeda J, Ringel F, Oberender C, Mills K, Quintarelli C, Pane F, Koschmieder S, Slany R, Schwarzer R, Saglio G, Hemmati P, van Lessen A, Amini L, Gresse M, Vagge E, Burmeister T, Serra A, Carson A, Schwarz M, Westermann J, Jundt F, Dörken B, le Coutre P.

Leuk Lymphoma. 2015 Jul;56(7):2105-13. doi: 10.3109/10428194.2014.981175. Epub 2015 Jan 23.


Insulin-like growth factor 1 is a direct HOXA9 target important for hematopoietic transformation.

Steger J, Füller E, Garcia-Cuellar MP, Hetzner K, Slany RK.

Leukemia. 2015 Apr;29(4):901-8. doi: 10.1038/leu.2014.287. Epub 2014 Sep 25.


Genomic inverse PCR for exploration of ligated breakpoints (GIPFEL), a new method to detect translocations in leukemia.

Fueller E, Schaefer D, Fischer U, Krell PF, Stanulla M, Borkhardt A, Slany RK.

PLoS One. 2014 Aug 19;9(8):e104419. doi: 10.1371/journal.pone.0104419. eCollection 2014.


Efficacy of cyclin-dependent-kinase 9 inhibitors in a murine model of mixed-lineage leukemia.

Garcia-Cuellar MP, Füller E, Mäthner E, Breitinger C, Hetzner K, Zeitlmann L, Borkhardt A, Slany RK.

Leukemia. 2014 Jul;28(7):1427-35. doi: 10.1038/leu.2014.40. Epub 2014 Jan 21.


MLL-ENL inhibits polycomb repressive complex 1 to achieve efficient transformation of hematopoietic cells.

Maethner E, Garcia-Cuellar MP, Breitinger C, Takacova S, Divoky V, Hess JL, Slany RK.

Cell Rep. 2013 May 30;3(5):1553-66. doi: 10.1016/j.celrep.2013.03.038. Epub 2013 Apr 25.


Multiple interferon regulatory factor and NF-κB sites cooperate in mediating cell-type- and maturation-specific activation of the human CD83 promoter in dendritic cells.

Stein MF, Lang S, Winkler TH, Deinzer A, Erber S, Nettelbeck DM, Naschberger E, Jochmann R, Stürzl M, Slany RK, Werner T, Steinkasserer A, Knippertz I.

Mol Cell Biol. 2013 Apr;33(7):1331-44. doi: 10.1128/MCB.01051-12. Epub 2013 Jan 22.

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