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Items: 1 to 20 of 508

1.

Protein kinase D regulates positive selection of CD4<sup>+</sup> thymocytes through phosphorylation of SHP-1.

Ishikawa E, Kosako H, Yasuda T, Ohmuraya M, Araki K, Kurosaki T, Saito T, Yamasaki S.

Nat Commun. 2016 Sep 27;7:12756. doi: 10.1038/ncomms12756.

PMID:
27670070
2.

Diabetic nephropathy: Role of podocyte SHP-1 in hyperglycaemic memory.

Carney EF.

Nat Rev Nephrol. 2016 Sep 19. doi: 10.1038/nrneph.2016.140. [Epub ahead of print] No abstract available.

PMID:
27641133
3.

Protein tyrosine phosphatase SHP-1 modulates osteoblast differentiation through direct association with and dephosphorylation of GSK3β.

Tang XL, Wang CN, Zhu XY, Ni X.

Mol Cell Endocrinol. 2016 Sep 8. pii: S0303-7207(16)30322-7. doi: 10.1016/j.mce.2016.08.048. [Epub ahead of print]

PMID:
27614023
4.

Persistent Insulin Resistance in Podocytes Caused by Epigenetic Changes of SHP-1 in Diabetes.

Lizotte F, Denhez B, Guay A, Gévry N, Côté AM, Geraldes P.

Diabetes. 2016 Sep 1. pii: db160254. [Epub ahead of print]

PMID:
27585521
5.

SHP-1 is directly activated by the aryl hydrocarbon receptor and regulates BCL-6 in the presence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

Phadnis-Moghe AS, Li J, Crawford RB, Kaminski NE.

Toxicol Appl Pharmacol. 2016 Aug 18;310:41-50. doi: 10.1016/j.taap.2016.08.014. [Epub ahead of print]

PMID:
27546522
6.
7.

Purity of transferred CD8(+) T cells is crucial for safety and efficacy of combinatorial tumor immunotherapy in the absence of SHP-1.

Watson HA, Dolton G, Ohme J, Ladell K, Vigar M, Wehenkel S, Hindley J, Mohammed RN, Miners K, Luckwell RA, Price DA, Matthews RJ, Ager A.

Immunol Cell Biol. 2016 Sep;94(8):802-8. doi: 10.1038/icb.2016.45. Epub 2016 Jul 19.

8.

SHP-1 promoter 2 methylation in cerebrospinal fluid for diagnosis of leptomeningeal epithelial-derived malignancy (carcinomatous meningitis).

Vinayanuwattikun C, Mingmalairak S, Jittapiromsak N, Thaipisuttikul I, Sriuranpong V, Mutirangura A, Shuangshoti S.

J Neurooncol. 2016 Sep;129(3):395-403. doi: 10.1007/s11060-016-2199-5. Epub 2016 Jul 11.

PMID:
27401153
9.

Disrupting VEGF-A paracrine and autocrine loops by targeting SHP-1 suppresses triple negative breast cancer metastasis.

Su JC, Mar AC, Wu SH, Tai WT, Chu PY, Wu CY, Tseng LM, Lee TC, Chen KF, Liu CY, Chiu HC, Shiau CW.

Sci Rep. 2016 Jul 1;6:28888. doi: 10.1038/srep28888.

10.

Besides an ITIM/SHP-1-dependent pathway, CD22 collaborates with Grb2 and plasma membrane calcium-ATPase in an ITIM/SHP-1-independent pathway of attenuation of Ca2+i signal in B cells.

Chen J, Wang H, Xu WP, Wei SS, Li HJ, Mei YQ, Li YG, Wang YP.

Oncotarget. 2016 Jun 2. doi: 10.18632/oncotarget.9794. [Epub ahead of print]

11.

Dephosphorylation of the adaptor LAT and phospholipase C-γ by SHP-1 inhibits natural killer cell cytotoxicity.

Matalon O, Fried S, Ben-Shmuel A, Pauker MH, Joseph N, Keizer D, Piterburg M, Barda-Saad M.

Sci Signal. 2016 May 24;9(429):ra54. doi: 10.1126/scisignal.aad6182.

PMID:
27221712
12.

CD5-mediated inhibition of TCR signaling proceeds normally in the absence of SHP-1.

Dong B, Somani AK, Love PE, Zheng X, Chen X, Zhang J.

Int J Mol Med. 2016 Jul;38(1):45-56. doi: 10.3892/ijmm.2016.2592. Epub 2016 May 17.

13.

Protein tyrosine phosphatase SHP-1: resurgence as new drug target for human autoimmune disorders.

Sharma Y, Bashir S, Bhardwaj P, Ahmad A, Khan F.

Immunol Res. 2016 Aug;64(4):804-19. doi: 10.1007/s12026-016-8805-y. Review.

PMID:
27216862
14.

Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells.

Getahun A, Beavers NA, Larson SR, Shlomchik MJ, Cambier JC.

J Exp Med. 2016 May 2;213(5):751-69. doi: 10.1084/jem.20150537. Epub 2016 Apr 25.

PMID:
27114609
15.

SHP-1: the next checkpoint target for cancer immunotherapy?

Watson HA, Wehenkel S, Matthews J, Ager A.

Biochem Soc Trans. 2016 Apr 15;44(2):356-62. doi: 10.1042/BST20150251. Review.

PMID:
27068940
16.

Ginkgetin Blocks Constitutive STAT3 Activation and Induces Apoptosis through Induction of SHP-1 and PTEN Tyrosine Phosphatases.

Baek SH, Lee JH, Ko JH, Lee H, Nam D, Lee SG, Yang WM, Um JY, Lee J, Kim SH, Shim BS, Ahn KS.

Phytother Res. 2016 Apr;30(4):567-76. doi: 10.1002/ptr.5557. Epub 2016 Jan 12.

PMID:
27059688
17.

A differential gene expression study: Ptpn6 (SHP-1)-insufficiency leads to neutrophilic dermatosis-like disease (NDLD) in mice.

Nesterovitch AB, Arbieva Z, Toth DM, Tharp MD, Glant TT.

J Dermatol Sci. 2016 Jul;83(1):17-25. doi: 10.1016/j.jdermsci.2016.03.005. Epub 2016 Mar 10.

PMID:
27020408
18.

Implication of protein tyrosine phosphatase SHP-1 in cancer-related signaling pathways.

Sharma Y, Ahmad A, Bashir S, Elahi A, Khan F.

Future Oncol. 2016 May;12(10):1287-98. doi: 10.2217/fon-2015-0057. Epub 2016 Mar 18.

PMID:
26987952
19.

Dovitinib Acts As a Novel Radiosensitizer in Hepatocellular Carcinoma by Targeting SHP-1/STAT3 Signaling.

Huang CY, Tai WT, Wu SY, Shih CT, Chen MH, Tsai MH, Kuo CW, Shiau CW, Hung MH, Chen KF.

Int J Radiat Oncol Biol Phys. 2016 Jun 1;95(2):761-71. doi: 10.1016/j.ijrobp.2016.01.016. Epub 2016 Jan 20.

PMID:
26960749
20.

[Overexpression of SHP-1 Enhances the Sensitivity of K562 Cells to Imatinib].

Li YH, Liu XD, Guo XF, Liu X, Luo JM, Li ZS, Zhang YX.

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016 Feb;24(1):46-51. doi: 10.7534/j.issn.1009-2137.2016.01.009. Chinese.

PMID:
26913392
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