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Items: 1 to 20 of 141

1.

Conformational equilibrium defines the variable induction of the multidrug-binding transcriptional repressor QacR.

Takeuchi K, Imai M, Shimada I.

Proc Natl Acad Sci U S A. 2019 Oct 1;116(40):19963-19972. doi: 10.1073/pnas.1906129116. Epub 2019 Sep 16.

PMID:
31527244
2.

Decreased conformational stability in the oncogenic N92I mutant of Ras-related C3 botulinum toxin substrate 1.

Toyama Y, Kontani K, Katada T, Shimada I.

Sci Adv. 2019 Aug 7;5(8):eaax1595. doi: 10.1126/sciadv.aax1595. eCollection 2019 Aug.

3.

Frequency selective coherence transfer NMR spectroscopy to study the structural dynamics of high molecular weight proteins.

Toyama Y, Shimada I.

J Magn Reson. 2019 Jul;304:62-77. doi: 10.1016/j.jmr.2019.05.004. Epub 2019 May 15.

PMID:
31129430
4.

In situ structural biology using in-cell NMR.

Nishida N, Ito Y, Shimada I.

Biochim Biophys Acta Gen Subj. 2019 May 16. pii: S0304-4165(19)30128-X. doi: 10.1016/j.bbagen.2019.05.007. [Epub ahead of print]

PMID:
31103749
5.

Function-related conformational dynamics of G protein-coupled receptors revealed by NMR.

Ueda T, Kofuku Y, Okude J, Imai S, Shiraishi Y, Shimada I.

Biophys Rev. 2019 Jun;11(3):409-418. doi: 10.1007/s12551-019-00539-w. Epub 2019 May 17. Review.

6.

Structural mechanism underlying G protein family-specific regulation of G protein-gated inwardly rectifying potassium channel.

Kano H, Toyama Y, Imai S, Iwahashi Y, Mase Y, Yokogawa M, Osawa M, Shimada I.

Nat Commun. 2019 May 1;10(1):2008. doi: 10.1038/s41467-019-10038-x.

7.

Conformational landscape alternations promote oncogenic activities of Ras-related C3 botulinum toxin substrate 1 as revealed by NMR.

Toyama Y, Kontani K, Katada T, Shimada I.

Sci Adv. 2019 Mar 13;5(3):eaav8945. doi: 10.1126/sciadv.aav8945. eCollection 2019 Mar.

8.

GPCR drug discovery: integrating solution NMR data with crystal and cryo-EM structures.

Shimada I, Ueda T, Kofuku Y, Eddy MT, Wüthrich K.

Nat Rev Drug Discov. 2019 Jan;18(1):59-82. doi: 10.1038/nrd.2018.180. Epub 2018 Nov 9. Review.

9.

Application of C-Terminal 7-Azabicyclo[2.2.1]heptane to Stabilize β-Strand-like Extended Conformation of a Neighboring α-Amino Acid.

Zhai L, Wang S, Nara M, Takeuchi K, Shimada I, Otani Y, Ohwada T.

J Org Chem. 2018 Nov 2;83(21):13063-13079. doi: 10.1021/acs.joc.8b01756. Epub 2018 Oct 16.

PMID:
30284439
10.

Phosphoinositide binding by the PH domain in ceramide transfer protein (CERT) is inhibited by hyperphosphorylation of an adjacent serine-repeat motif.

Sugiki T, Egawa D, Kumagai K, Kojima C, Fujiwara T, Takeuchi K, Shimada I, Hanada K, Takahashi H.

J Biol Chem. 2018 Jul 13;293(28):11206-11217. doi: 10.1074/jbc.RA118.002465. Epub 2018 May 30.

11.

Functional roles of Mg2+ binding sites in ion-dependent gating of a Mg2+ channel, MgtE, revealed by solution NMR.

Maruyama T, Imai S, Kusakizako T, Hattori M, Ishitani R, Nureki O, Ito K, Maturana AD, Shimada I, Osawa M.

Elife. 2018 Apr 3;7. pii: e31596. doi: 10.7554/eLife.31596.

12.

Structural basis for the ethanol action on G-protein-activated inwardly rectifying potassium channel 1 revealed by NMR spectroscopy.

Toyama Y, Kano H, Mase Y, Yokogawa M, Osawa M, Shimada I.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3858-3863. doi: 10.1073/pnas.1722257115. Epub 2018 Mar 26.

13.

Deuteration and selective labeling of alanine methyl groups of β2-adrenergic receptor expressed in a baculovirus-insect cell expression system.

Kofuku Y, Yokomizo T, Imai S, Shiraishi Y, Natsume M, Itoh H, Inoue M, Nakata K, Igarashi S, Yamaguchi H, Mizukoshi T, Suzuki EI, Ueda T, Shimada I.

J Biomol NMR. 2018 Jul;71(3):185-192. doi: 10.1007/s10858-018-0174-5. Epub 2018 Mar 8.

PMID:
29520682
14.

Balanced Regulation of Redox Status of Intracellular Thioredoxin Revealed by in-Cell NMR.

Mochizuki A, Saso A, Zhao Q, Kubo S, Nishida N, Shimada I.

J Am Chem Soc. 2018 Mar 14;140(10):3784-3790. doi: 10.1021/jacs.8b00426. Epub 2018 Mar 6.

PMID:
29509009
15.

Characterization of the multimeric structure of poly(A)-binding protein on a poly(A) tail.

Sawazaki R, Imai S, Yokogawa M, Hosoda N, Hoshino SI, Mio M, Mio K, Shimada I, Osawa M.

Sci Rep. 2018 Jan 23;8(1):1455. doi: 10.1038/s41598-018-19659-6.

16.

Phosphorylation-induced conformation of β2-adrenoceptor related to arrestin recruitment revealed by NMR.

Shiraishi Y, Natsume M, Kofuku Y, Imai S, Nakata K, Mizukoshi T, Ueda T, Iwaï H, Shimada I.

Nat Commun. 2018 Jan 15;9(1):194. doi: 10.1038/s41467-017-02632-8.

17.

Erratum to: Nitrogen detected TROSY at high field yields high resolution and sensitivity for protein NMR.

Takeuchi K, Arthanari H, Shimada I, Wagner G.

J Biomol NMR. 2017 Dec;69(4):245. doi: 10.1007/s10858-017-0131-8.

PMID:
29230599
18.

Dynamic domain arrangement of CheA-CheY complex regulates bacterial thermotaxis, as revealed by NMR.

Minato Y, Ueda T, Machiyama A, Iwaï H, Shimada I.

Sci Rep. 2017 Nov 28;7(1):16462. doi: 10.1038/s41598-017-16755-x.

19.

Nuclear Magnetic Resonance Approaches for Characterizing Protein-Protein Interactions.

Toyama Y, Mase Y, Kano H, Yokogawa M, Osawa M, Shimada I.

Methods Mol Biol. 2018;1684:115-128. doi: 10.1007/978-1-4939-7362-0_10.

PMID:
29058188
20.

A small-molecule compound inhibits a collagen-specific molecular chaperone and could represent a potential remedy for fibrosis.

Ito S, Ogawa K, Takeuchi K, Takagi M, Yoshida M, Hirokawa T, Hirayama S, Shin-Ya K, Shimada I, Doi T, Goshima N, Natsume T, Nagata K.

J Biol Chem. 2017 Dec 8;292(49):20076-20085. doi: 10.1074/jbc.M117.815936. Epub 2017 Oct 12.

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